<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cddc8-5eab-78a6-aee0-33da09eadf6b,g:caaa6e47-e1f2-49b9-aac6-61d7895d83b9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.fhlbdm.com/role/Cover" xlink:type="simple" xlink:href="fhlbdm-20260424.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.fhlbdm.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019cddc8-5eab-7118-b2b8-8f20afb808e0" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_DocumentPeriodEndDate_019cddc8-5eab-7118-b2b8-8f20afb808e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019cddc8-5eab-73cb-832f-ab49c4da74f8" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityRegistrantName_019cddc8-5eab-73cb-832f-ab49c4da74f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019cddc8-5eab-7845-8749-a7f8ddd1897c" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019cddc8-5eab-7845-8749-a7f8ddd1897c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019cddc8-5eab-74e5-b9d0-bd079153947f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityFileNumber_019cddc8-5eab-74e5-b9d0-bd079153947f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019cddc8-5eab-7bfd-a367-a1bbf5f37aa4" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityTaxIdentificationNumber_019cddc8-5eab-7bfd-a367-a1bbf5f37aa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019cddc8-5eab-72ff-a44a-feb755f5d2ea" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityAddressPostalZipCode_019cddc8-5eab-72ff-a44a-feb755f5d2ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019cddc8-5eab-73da-a138-e69b9d372cf2" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_SolicitingMaterial_019cddc8-5eab-73da-a138-e69b9d372cf2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019cddc8-5eab-7a4c-b26b-63297e0cfeb5" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_PreCommencementTenderOffer_019cddc8-5eab-7a4c-b26b-63297e0cfeb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019cddc8-5eab-7de9-9500-10877d93afa2" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019cddc8-5eab-7de9-9500-10877d93afa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019cddc8-5eab-78fb-a4e1-f3051e6c690e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityEmergingGrowthCompany_019cddc8-5eab-78fb-a4e1-f3051e6c690e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019cddc8-5eab-7502-b5de-4f3cc1359c0f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_AmendmentFlag_019cddc8-5eab-7502-b5de-4f3cc1359c0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019cddc8-5eab-7516-a989-cd14d9cd2056" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityCentralIndexKey_019cddc8-5eab-7516-a989-cd14d9cd2056" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019cddc8-5eab-7df0-9053-3b2eca0a4017" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityAddressAddressLine1_019cddc8-5eab-7df0-9053-3b2eca0a4017" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019cddc8-5eab-7798-9c93-c3ef3d8f96a8" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityAddressStateOrProvince_019cddc8-5eab-7798-9c93-c3ef3d8f96a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019cddc8-5eab-7b2d-9bc9-dc88ee823c28" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_DocumentType_019cddc8-5eab-7b2d-9bc9-dc88ee823c28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019cddc8-5eab-7dd7-a45a-e458379a3093" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_CityAreaCode_019cddc8-5eab-7dd7-a45a-e458379a3093" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019cddc8-5eab-7bec-b95e-642ced091646" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_LocalPhoneNumber_019cddc8-5eab-7bec-b95e-642ced091646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019cddc8-5eab-7319-8484-131bc02ee07a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_EntityAddressCityOrTown_019cddc8-5eab-7319-8484-131bc02ee07a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019cddc8-5eab-70e9-8f89-a5357cfcd775" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019cddc8-5eab-7f95-9c54-bdc5118d11c5" xlink:to="loc_dei_WrittenCommunications_019cddc8-5eab-70e9-8f89-a5357cfcd775" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>