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We do not have, nor do we plan to establish, any program, plan or practice to time equity award grants in coordination with releasing material non-public information. <table cellpadding="0" cellspacing="0" id="xdx_889_eecd--PvpTableTextBlock_z2lGxGJUMlH2" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Year</td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48D_eecd--PeoTotalCompAmt_hecd--IndividualAxis__ecd--PeoMember_zowo2leLE9bj" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Summary Compensation Table Total for PEO (1)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_482_eecd--PeoActuallyPaidCompAmt_z9mKOgsJ8x5f" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Compensation Actually Paid to PEO (1)(2)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_489_eecd--NonPeoNeoAvgTotalCompAmt_z9t4YkQxxHIi" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Average Summary Compensation Table Total for Other NEOs (1)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_489_eecd--NonPeoNeoAvgCompActuallyPaidAmt_zf0dPrYqtt2d" style="border-bottom: Black 1pt solid; text-align: center">Average Compensation Actually Paid to Other NEOs (1)(2)</td><td style="padding-bottom: 1pt"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48D_eecd--TotalShareholderRtnAmt_zEBo66tHmEkf" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Total Stockholder Return (3)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48A_eecd--PeerGroupTotalShareholderRtnAmt_z6azbaobqg2k" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Peer Group Total Stockholder Return (4)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_482_eus-gaap--NetIncomeLoss_iN_di_zIMOVTenQV4a" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Net Loss (5)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_483_eecd--CoSelectedMeasureAmt_uUSD_za1ujjpOUPQf" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Company-Selected Measure (Revenue) (6)</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_414_20250101__20251231_zXJxrKrUN7Wf" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 10%; text-align: center">2025</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 8%; text-align: right">23,606,274</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 8%; text-align: right">33,129,871</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">3,563,795</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">16,340,716</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">714</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">120</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">5,139,000</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 7%; text-align: right">272,303,000</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_416_20240101__20241231_z2YhE5ots2Dk" style="vertical-align: bottom; background-color: White"> <td style="text-align: center">2024</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">1,358,490</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">21,472,938</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">796,334</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">9,025,662</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">489</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">91</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">17,481,000</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">199,614,000</td><td style="text-align: left"> </td></tr> <tr id="xdx_410_20230101__20231231_ztmEYM3xb8if" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: center">2023</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">15,256,463</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">3,113,361</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">6,472,781</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">1,934,673</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">163</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">92</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">24,411,000</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">130,193,000</td><td style="text-align: left"> </td></tr> <tr id="xdx_41F_20220101__20221231_zEl5TEEPLlL2" style="vertical-align: bottom; background-color: White"> <td style="text-align: center">2022</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">1,195,141</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">9,511,499</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">710,637</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">3,053,124</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">215</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">89</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">14,086,000</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">88,595,000</td><td style="text-align: left"> </td></tr> <tr id="xdx_412_20210101__20211231_zefKl6rbxNJh" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: center">2021</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">7,321,467</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">8,694,376</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">3,014,506</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">3,538,146</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">126</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">99</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">18,007,000</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">72,476,000</td><td style="text-align: left"> </td></tr> </table> 23606274 33129871 3563795 16340716 714 120

-5139000

272303000 1358490 21472938 796334 9025662 489 91

-17481000

199614000 15256463 3113361 6472781 1934673 163 92

-24411000

130193000 1195141 9511499 710637 3053124 215 89

-14086000

88595000 7321467 8694376 3014506 3538146 126 99

-18007000

72476000 Mark Baum was our PEO for each year presented. Mark Baum Mark Baum Mark Baum Mark Baum Mark Baum <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 97%; margin-left: 0.25in"> <tr style="display: none; vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center; padding-bottom: 1pt">Adjustments</td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: left"> </td><td id="xdx_498_20250101__20251231__ecd--IndividualAxis__ecd--PeoMember_zARlvV80x408" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td id="xdx_49A_20240101__20241231__ecd--IndividualAxis__ecd--PeoMember_zFPezmXdYE1d" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2024</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td id="xdx_49A_20230101__20231231__ecd--IndividualAxis__ecd--PeoMember_z934jCFhSe2h" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2023</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td id="xdx_495_20220101__20221231__ecd--IndividualAxis__ecd--PeoMember_zOlMrt0mZ863" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td id="xdx_497_20210101__20211231__ecd--IndividualAxis__ecd--PeoMember_zDKSWvIr8smb" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: left"> </td></tr> <tr style="vertical-align: bottom"> <td colspan="21" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">CEO – Mark L. Baum – Equity Award Adjustments</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center; padding-bottom: 1pt">Adjustments</td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: left"> </td><td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2024</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2023</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: center"> </td><td style="text-align: center; font-weight: bold; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center"> </td><td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 35%; text-align: left">SCT Amounts</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98F_eecd--PeoTotalCompAmt_c20250101__20251231_zkkR8FLhPRM4" style="width: 9%; text-align: right">23,606,274</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_989_eecd--PeoTotalCompAmt_c20240101__20241231_zEJZ9TlA5hu5" style="width: 9%; text-align: right">1,358,490</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_983_eecd--PeoTotalCompAmt_c20230101__20231231_zD9Ok7U8thV6" style="width: 9%; text-align: right">15,256,463</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_980_eecd--PeoTotalCompAmt_c20220101__20221231_zTfXbchr5px5" style="width: 9%; text-align: right">1,195,141</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_987_eecd--PeoTotalCompAmt_c20210101__20211231_zqSsJkK7gC51" style="width: 9%; text-align: right">7,321,467</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_405_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--AggregateValueForStockAwardsAndOptionAwardsIncludedInSCTAmountsForTheCoveredFiscalYearMember_zO9FGBCDU5oj" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">(Subtract): Aggregate value for stock awards and option awards included in SCT amounts for the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(22,294,873</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(14,150,821</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(6,251,841</td><td style="text-align: left">)</td></tr> <tr id="xdx_40D_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--FairValueAtYearEndOfAwardsGrantedDuringTheCoveredFiscalYearThatWereOutstandingAndUnvestedAtTheCoveredFiscalYearEndMember_zmazLZpv6Vy6" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">39,052,697</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">5,504,217</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">6,962,777</td><td style="text-align: left"> </td></tr> <tr id="xdx_403_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--YearOverYearChangeInFairValueAtCoveredFiscalYearEndOfAwardsGrantedInAnyPriorFiscalYearThatWereOutstandingAndUnvestedAtTheCoveredFiscalYearEndMember_z7kpBr52lonl" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Add (Subtract): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">20,070,948</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">7,390,670</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(1,491,366</td><td style="text-align: left">)</td></tr> <tr id="xdx_406_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--VestingDateFairValueOfAwardsGrantedAndVestedDuringTheCoveredFiscalYearMember_zG93vZUqoCTe" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Vesting date fair value of awards granted and vested during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td></tr> <tr id="xdx_404_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--ChangeAsOfTheVestingDateFromTheEndOfThePriorFiscalYearInFairValueOfAwardsGrantedInAnyPriorFiscalYearForWhichVestingConditionsWereSatisfiedDuringTheCoveredFiscalYearMember_zhzXYWZYgoQb" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">(Subtract) Add: Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(7,234,227</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">43,500</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(3,496,498</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">925,688</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">2,153,339</td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--FairValueAtEndOfPriorFiscalYearOfAwardsGrantedInAnyPriorFiscalYearThatFailedToMeetTheApplicableVestingConditionsDuringTheCoveredFiscalYearMember_zVCy7zhtAfA2" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Fair value at end of prior fiscal year of awards granted in any prior fiscal year that failed to meet the applicable vesting conditions during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td></tr> <tr id="xdx_403_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsOrOtherEarningsPaidOnStockOrOptionAwardsInTheCoveredFiscalYearPriorToVestingIfNotOtherwiseIncludedInTheTotalCompensationForTheCoveredFiscalYearMember_zgo0tPohazdd" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Add: Dividends or other earnings paid on stock or option awards in the covered fiscal year prior to vesting if not otherwise included in the total compensation for the covered fiscal year</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_409_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsOrOtherEarningsPaidOnStockOrOptionAwardsInTheCoveredFiscalYearPriorToVestingIfNotOtherwiseIncludedInTheTotalCompensationForTheCoveredFiscalYearMember_zChwBhf7U2ab" style="display: none; vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Adjustment to Compensation Amount</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">CAP Amounts (as calculated)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eecd--PeoActuallyPaidCompAmt_c20250101__20251231_zhNkgkOH045c" style="border-bottom: Black 2.5pt double; text-align: right">33,129,871</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98E_eecd--PeoActuallyPaidCompAmt_c20240101__20241231_zOKmi1aBYiE4" style="border-bottom: Black 2.5pt double; text-align: right">21,472,938</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_983_eecd--PeoActuallyPaidCompAmt_c20230101__20231231_zvfDYbxfQ5Jb" style="border-bottom: Black 2.5pt double; text-align: right">3,113,361</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98C_eecd--PeoActuallyPaidCompAmt_c20220101__20221231_zWGHgI9wFT93" style="border-bottom: Black 2.5pt double; text-align: right">9,511,499</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98A_eecd--PeoActuallyPaidCompAmt_c20210101__20211231_ziAmOXMRspUd" style="border-bottom: Black 2.5pt double; text-align: right">8,694,376</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 97%; margin-left: 0.25in"> <tr style="display: none; vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Adjustments</td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_49C_20250101__20251231__ecd--IndividualAxis__ecd--NonPeoNeoMember_z5YTOQ4lu4Bl" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025*</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_494_20240101__20241231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zr13DsJU53p2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2024*</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_49A_20230101__20231231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zw7KIIt1MbS2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2023*</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_49E_20220101__20221231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zbwjlygNfkdh" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022*</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_496_20210101__20211231__ecd--IndividualAxis__ecd--NonPeoNeoMember_z3hCQFJec5Z7" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021*</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td colspan="21" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Non-CEO Equity Award Adjustments*</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Adjustments</td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2024</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2023</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 35%; text-align: left">SCT Amounts</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_980_eecd--NonPeoNeoAvgTotalCompAmt_c20250101__20251231_fKg_____zbu7QSrMs28j" style="width: 9%; text-align: right">3,563,795</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_983_eecd--NonPeoNeoAvgTotalCompAmt_c20240101__20241231_fKg_____z66Ikq0VrSxc" style="width: 9%; text-align: right">796,334</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_982_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_fKg_____zXLIuqNuflS3" style="width: 9%; text-align: right">6,472,781</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_fKg_____z2SHOdE7KgFf" style="width: 9%; text-align: right">710,637</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgTotalCompAmt_c20210101__20211231_fKg_____zq2eaZrBLL2e" style="width: 9%; text-align: right">3,014,506</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_404_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--AggregateValueForStockAwardsAndOptionAwardsIncludedInSCTAmountsForTheCoveredFiscalYearMember_zOWL5zcSX475" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">(Subtract): Aggregate value for stock awards and option awards included in SCT amounts for the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(2,973,779</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(5,788,972</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(2,345,183</td><td style="text-align: left">)</td></tr> <tr id="xdx_40C_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--FairValueAtYearEndOfAwardsGrantedDuringTheCoveredFiscalYearThatWereOutstandingAndUnvestedAtTheCoveredFiscalYearEndMember_zvriD42Fw5N" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">19,872,664</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">2,251,725</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">2,642,227</td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--YearOverYearChangeInFairValueAtCoveredFiscalYearEndOfAwardsGrantedInAnyPriorFiscalYearThatWereOutstandingAndUnvestedAtTheCoveredFiscalYearEndMember_zXPzD5k11tF9" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Add (Subtract): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">8,210,842</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">1,948,868</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">46,479</td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--VestingDateFairValueOfAwardsGrantedAndVestedDuringTheCoveredFiscalYearMember_zv1tjKQTwP4g" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Vesting date fair value of awards granted and vested during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td></tr> <tr id="xdx_409_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--ChangeAsOfTheVestingDateFromTheEndOfThePriorFiscalYearInFairValueOfAwardsGrantedInAnyPriorFiscalYearForWhichVestingConditionsWereSatisfiedDuringTheCoveredFiscalYearMember_zg76sAJHhish" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">(Subtract) Add: Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(4,121,964</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">18,486</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(1,000,861</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">393,619</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">180,117</td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--FairValueAtEndOfPriorFiscalYearOfAwardsGrantedInAnyPriorFiscalYearThatFailedToMeetTheApplicableVestingConditionsDuringTheCoveredFiscalYearMember_zvfVawNgPoA2" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left">Add: Fair value at end of prior fiscal year of awards granted in any prior fiscal year that failed to meet the applicable vesting conditions during the covered fiscal year</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">-</td><td style="text-align: left"> </td></tr> <tr id="xdx_40E_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsOrOtherEarningsPaidOnStockOrOptionAwardsInTheCoveredFiscalYearPriorToVestingIfNotOtherwiseIncludedInTheTotalCompensationForTheCoveredFiscalYearMember_zU2SP9ceArlh" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Add: Dividends or other earnings paid on stock or option awards in the covered fiscal year prior to vesting if not otherwise included in the total compensation for the covered fiscal year</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_406_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsOrOtherEarningsPaidOnStockOrOptionAwardsInTheCoveredFiscalYearPriorToVestingIfNotOtherwiseIncludedInTheTotalCompensationForTheCoveredFiscalYearMember_z4cELwRLdZZ7" style="display: none; vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Adjustment to Compensation Amount</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left">$</td><td style="border-bottom: Black 1pt solid; text-align: right">-</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 2.5pt">CAP Amounts (as calculated)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_984_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20250101__20251231_fKg_____zaUzZ1hKT808" style="border-bottom: Black 2.5pt double; text-align: right">16,340,716</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_986_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20240101__20241231_fKg_____zHifoDhKCiqf" style="border-bottom: Black 2.5pt double; text-align: right">9,025,662</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_987_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_fKg_____zBNHjs7ivj3f" style="border-bottom: Black 2.5pt double; text-align: right">1,934,673</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_fKg_____zp7fEDcmEh3j" style="border-bottom: Black 2.5pt double; text-align: right">3,053,124</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20210101__20211231_fKg_____zsuddR1e7xA7" style="border-bottom: Black 2.5pt double; text-align: right">3,538,146</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <table cellpadding="0" cellspacing="0" style="margin-top: 0; margin-bottom: 6pt; width: 100%"><tr style="vertical-align: top; text-align: justify"> <td id="xdx_F0E_zwdH6Qla17bj" style="width: 15pt; text-align: right">*</td><td id="xdx_F11_zxQzZUygluV3" style="text-align: justify">The Non-CEO named executive officers for 2025 include Andrew R. Boll, John P. Saharek, Francis W. Mullery and Amir H. Shojaei, and for 2024 through 2021 include Andrew R. Boll and John P. Saharek.</td> </tr></table> 23606274 1358490 15256463 1195141 7321467 -22294873 -14150821 -6251841 39052697 5504217 6962777 20070948 7390670 -1491366 -7234227 43500 -3496498 925688 2153339 33129871 21472938 3113361 9511499 8694376 3563795 796334 6472781 710637 3014506 -2973779 -5788972 -2345183 19872664 2251725 2642227 8210842 1948868 46479 -4121964 18486 -1000861 393619 180117 16340716 9025662 1934673 3053124 3538146 Peer group TSR represents the cumulative growth of a hypothetical $100 investment made as of December 31, 2020 in the Nasdaq Biotechnology Index, reflected as of the end of each respective year. Relationship Between Compensation Actually Paid and TSR As illustrated in the table above, compensation actually paid to our PEO and Non-PEO NEOs fluctuates from year to year, in part due to changes in the Company’s stock price and in part due to fluctuations in equity awards granted to our NEOs year-to-year. Because equity awards are revalued based on stock price performance, increases in our stock price generally result in higher compensation actually paid, while decreases in stock price generally result in lower compensation actually paid. Although TSR is not used as a direct input in determining compensation, the Compensation Committee believes that the use of equity-based compensation aligns executive interests with those of stockholders by linking a substantial portion of compensation to stock price performance over time. Relationship Between Compensation Actually Paid and Net Loss The Company has historically reported net losses as it continues to invest in the growth of its business, including commercial expansion, product development and strategic initiatives. As a result, net loss is not used by the Compensation Committee as a primary measure in determining executive compensation. Instead, the Compensation Committee evaluates performance based on metrics it believes better reflect the Company’s operating progress and long-term value creation, including revenue, adjusted EBITDA, product performance and key strategic initiatives, which are also reflected in the Company’s selected performance measures for purposes of the pay-versus-performance disclosure. Accordingly, compensation actually paid to our named executive officers is not directly correlated with net loss. Relationship Between Compensation Actually Paid and Revenue The Company has identified Revenue as its Company-Selected Measure, which represents the most important financial performance measure used to link executive compensation actually paid to Company performance. Compensation actually paid to our PEO and Non-PEO NEOs is influenced by this measure primarily through our annual incentive compensation program, which is designed to reward achievement of key financial and operational objectives. In general: <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">When the Company achieves or exceeds its performance targets for this measure, annual incentive payouts increase, contributing to higher compensation actually paid; and</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">When performance falls below target levels, incentive payouts are reduced, resulting in lower compensation actually paid.</td></tr></table> The Compensation Committee selected this measure because it reflects the Company’s operational performance and growth and is a key driver of long-term stockholder value. Relationship Between Company Performance and Peer Group TSR The Company’s TSR is compared to the TSR of the Nasdaq Biotechnology Index, as required by SEC rules. The peer group TSR is calculated using the same methodology as the Company’s TSR and provides context for evaluating relative stockholder return performance. While the Compensation Committee does not directly benchmark compensation decisions to peer group TSR, it considers overall market conditions and relative performance in evaluating the competitiveness and effectiveness of the Company’s executive compensation program. Tabular List of Most Important Performance Measures The following represents the most important financial and non-financial performance measures used by the Company to link executive compensation actually paid to Company performance for the most recently completed fiscal year: <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0; margin-bottom: 0"><tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">Revenue;</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">Strategic and operational milestones;</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">Product development and commercialization objectives; and</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"></td><td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">●</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">Individual performance objectives.</td></tr></table> Mark Baum was our PEO for each year presented. The following tables set forth adjustments made during each year presented to arrive at the CAP Amounts for our PEO and Other NEOs, respectively, during each year: Total Stockholder Return (“TSR”) represents the cumulative growth of a hypothetical $100 investment in the Company made as of December 31, 2020, reflected as of the end of each respective year. Peer group TSR represents the cumulative growth of a hypothetical $100 investment made as of December 31, 2020 in the Nasdaq Biotechnology Index, reflected as of the end of each respective year. Represents the amount of net loss reflected in our consolidated financial statements for each covered fiscal year. The Company selected revenue as its most important financial performance measure because it reflects the Company’s commercial growth and operational execution, which are key drivers of long-term stockholder value. The Non-CEO named executive officers for 2025 include Andrew R. Boll, John P. Saharek, Francis W. Mullery and Amir H. Shojaei, and for 2024 through 2021 include Andrew R. Boll and John P. Saharek.