X0609 4 2026-05-12 0 0001377121 Protagonist Therapeutics, Inc PTGX 0001120477 PATEL DINESH V PH D false C/O PROTAGONIST THERAPEUTICS, INC. 7707 GATEWAY BLVD., SUITE 140 NEWARK CA 94560-1160 1 1 0 0 President and CEO 0 Common Stock 2026-05-12 4 M 0 75000 21.58 A 598478 D Common Stock 2026-05-12 4 S 0 75000 100.12 D 523478 D Stock Option (right to buy) 21.58 2026-05-12 4 M 0 75000 0.00 D 2026-10-11 Common Stock 75000 225000 D The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $98.83 to $103.50. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. These stock options are fully vested and will expire on October 11, 2026. /s/ Matthew Gosling, Attorney-in-Fact for Dinesh V. Patel, Ph.D. 2026-05-12