0001593899 ecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 ecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 2022-01-01 2022-12-31 0001593899 ecd:EqtyAwrdsAdjsMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 0001593899 ecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 0001593899 2024-01-01 2024-12-31 0001593899 ecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 0001593899 ecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 2025-01-01 2025-12-31 0001593899 2023-01-01 2023-12-31 0001593899 2021-01-01 2021-12-31 0001593899 ecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 0001593899 ecd:EqtyAwrdsAdjsMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 avir:ExclusionOfStockAwardsAndOptionAwardsMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 0001593899 avir:ExclusionOfStockAwardsAndOptionAwardsMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 ecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember ecd:PeoMember 2025-01-01 2025-12-31 0001593899 ecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember ecd:NonPeoNeoMember 2025-01-01 2025-12-31 iso4217:USD 0001593899 false DEF 14A ATEA PHARMACEUTICALS, INC. true Policies and Practices Relating to the Timing of Equity Awards Our general practice is to not grant equity awards in anticipation of the release of material nonpublic information or time the release of material nonpublic information for the purpose of affecting the value of executive compensation. The Compensation Committee uses its business judgment to determine the size of our equity awards and would consider any material nonpublic information that is known to the Compensation Committee before granting an award. Although we do not have a formal policy with respect to the timing of our equity award grants, the Compensation Committee has historically granted awards on a predetermined annual schedule. During 2025, we did not grant stock options to our NEOs during the four business days prior to or the one business day following the filing of our periodic reports or the filing or furnishing of a Form 8-K that disclosed material nonpublic information. Our general practice is to not grant equity awards in anticipation of the release of material nonpublic information or time the release of material nonpublic information for the purpose of affecting the value of executive compensation. Although we do not have a formal policy with respect to the timing of our equity award grants, the Compensation Committee has historically granted awards on a predetermined annual schedule. false false true Pay Versus Performance In accordance with rules adopted by the SEC pursuant to the Dodd-Frank Act, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and Non-PEO NEOs and Company performance for the fiscal years listed below. We did not use any financial performance measure to link “Compensation Actually Paid” to our NEOs to our Company performance in the most recently completed fiscal year; accordingly, this disclosure does not present a Company-Selected Measure in the table below nor a Tabular List of our most important financial metrics. Despite being a smaller reporting company under SEC rules, we voluntarily provide supplementary pay versus performance disclosure for five fiscal years to enhance transparency of our compensation structure. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown. For additional discussion of how executive compensation is linked to Company performance, please see the section labeled “Named Executive Officer Compensation Overview” in this Proxy Statement. <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:85.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:11.502%;box-sizing:content-box;"></td> <td style="width:14.383%;box-sizing:content-box;"></td> <td style="width:15.063%;box-sizing:content-box;"></td> <td style="width:14.043%;box-sizing:content-box;"></td> <td style="width:15.063%;box-sizing:content-box;"></td> <td style="width:8.962%;box-sizing:content-box;"></td> <td style="width:8.962%;box-sizing:content-box;"></td> <td style="width:12.022%;box-sizing:content-box;"></td> </tr> <tr style="height:37.15pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Summary Compensation Table Total for PEO1($)</td> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Compensation Actually Paid to PEO1, 2, 3($)</td> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Summary Compensation Table Total for Non-PEO NEOs1 ($)</td> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Compensation Actually Paid to Non-PEO NEOs1,2,3 ($)</td> <td colspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Value of Initial Fixed $100 Investment based on:4</td> <td rowspan="2" style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Net Income ($ Millions)</td> </tr> <tr style="height:37.15pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">TSR ($)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Peer Group TSR ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,403,752 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,602,523 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,567,307 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,637,215 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">8.54 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">124.75 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(158)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2024</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">4,202,323 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">4,303,599 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,832,708 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,682,859 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">8.02 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">93.49 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(168)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2023</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">5,925,790 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,404,758 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,859,249 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,040,141 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">7.30 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">94.03 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(136)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2022</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">5,878,026 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">705,198 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,860,101 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">387,388 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">11.51 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">89.90 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(116)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2021</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">34,104,892 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(1,459,864)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">8,024,996 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(7,212,212)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">21.40 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">100.02 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">121 </td> </tr> </table> <div style="font-size:12pt;font-family:Times New Roman;">1. Jean-Pierre Sommadossi was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below. <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:100.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> </tr> <tr style="height:15.75pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">2021</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2022</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2023</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2024</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Wayne Foster</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> </tr> </table></div> 2. The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below. 3. Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> </tr> <tr style="height:31.5pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Summary Compensation Table Total for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Exclusion of Stock Awards and Option Awards for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Inclusion of Equity Values for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Compensation Actually Paid to PEO ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,403,752 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(2,278,168)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,476,939</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,602,523</td> </tr> </table> <div style="font-size:8pt;font-family:'Aptos',sans-serif;"> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> </tr> <tr style="height:31.5pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Summary Compensation Table Total for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Inclusion of Equity Values for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Compensation Actually Paid to Non-PEO NEOs ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,567,307 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(801,520)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">871,428</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,637,215 </td> </tr> </table></div> The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: <div style="font-size:8pt;font-family:'Aptos',sans-serif;"> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:75.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:16.683%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.723%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.603%;box-sizing:content-box;"></td> </tr> <tr style="height:57pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Total - Inclusion ofEquity Values for PEO ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,388,299 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">85,459</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">214,939 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(211,758)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,476,939 </td> </tr> </table></div> <div style="font-size:10pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:75.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:16.683%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.723%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.603%;box-sizing:content-box;"></td> </tr> <tr style="height:57pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Total - Average Inclusion ofEquity Values for Non-PEO NEOs ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">823,973 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">18,850 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">88,614</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(60,009)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">871,428</td> </tr> </table> </div>4. The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2025. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. 3403752 3602523 1567307 1637215 8.54 124.75

-158000000

4202323 4303599 1832708 1682859 8.02 93.49

-168000000

5925790 3404758 1859249 1040141 7.3 94.03

-136000000

5878026 705198 1860101 387388 11.51 89.9

-116000000

34104892 -1459864 8024996 -7212212 21.4 100.02

121000000

1. Jean-Pierre Sommadossi was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below. <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:100.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> <td style="width:20%;box-sizing:content-box;"></td> </tr> <tr style="height:15.75pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">2021</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2022</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2023</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2024</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Andrea Corcoran</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Janet Hammond, MD, PhD</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Maria Arantxa Horga, MD</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Wayne Foster</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">John Vavricka</td> </tr> </table> Jean-Pierre Sommadossi Jean-Pierre Sommadossi Jean-Pierre Sommadossi Jean-Pierre Sommadossi Jean-Pierre Sommadossi <div> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> </tr> <tr style="height:31.5pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Summary Compensation Table Total for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Exclusion of Stock Awards and Option Awards for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Inclusion of Equity Values for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Compensation Actually Paid to PEO ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,403,752 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(2,278,168)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,476,939</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">3,602,523</td> </tr> </table></div> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:75.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:16.683%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.723%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.603%;box-sizing:content-box;"></td> </tr> <tr style="height:57pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Total - Inclusion ofEquity Values for PEO ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,388,299 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">85,459</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">214,939 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(211,758)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2,476,939 </td> </tr> </table> 3403752 -2278168 2476939 3602523 <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:20.024%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> <td style="width:19.984%;box-sizing:content-box;"></td> </tr> <tr style="height:31.5pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Summary Compensation Table Total for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Inclusion of Equity Values for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Compensation Actually Paid to Non-PEO NEOs ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,567,307 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(801,520)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">871,428</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">1,637,215 </td> </tr> </table> <table style="margin-left:auto;border-spacing:0;table-layout:auto;width:75.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:16.683%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.723%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.663%;box-sizing:content-box;"></td> <td style="width:16.603%;box-sizing:content-box;"></td> </tr> <tr style="height:57pt;background-color:#329b88;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;border-left:0.5pt solid;padding-right:0.08in;">Year</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-top:0.5pt solid;padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">Total - Average Inclusion ofEquity Values for Non-PEO NEOs ($)</td> </tr> <tr style="height:15.75pt;word-break:break-word;white-space:pre-wrap;text-align:left;"> <td style="padding-top:0in;border-right:0.5pt solid;border-left:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">2025</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">823,973 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">18,850 </td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">88,614</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">(60,009)</td> <td style="padding-top:0in;border-right:0.5pt solid;padding-left:0.08in;vertical-align:middle;padding-bottom:0in;border-bottom:0.5pt solid;padding-right:0.08in;">871,428</td> </tr> </table> 1567307 -801520 871428 1637215 2388299 85459 214939 -211758 2476939 823973 18850 88614 -60009 871428 The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2025. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the cumulative TSR for the Company over the five most recently completed fiscal years, and the NASDAQ Biotechnology Index TSR over the same period. <img alt="img2852109_89.gif" src="img2852109_89.gif" style="width:720px;height:401px;"/> The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the cumulative TSR for the Company over the five most recently completed fiscal years, and the NASDAQ Biotechnology Index TSR over the same period. <img alt="img2852109_89.gif" src="img2852109_89.gif" style="width:720px;height:401px;"/> The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our net income during the five most recently completed fiscal years.<img alt="img2852109_90.gif" src="img2852109_90.gif" style="width:720px;height:403px;"/>