144 0001114357 XXXXXXXX LIVE 0001717115 Tempus AI, Inc. 001-42130 600 W. Chicago Ave., Suite 510 Chicago IL 60654 800-976-5448 Eric Lefkofsky Officer Director 10% Stockholder Class A Common J.P. Morgan Securities LLC 270 Park Avenue - 10th Floor New York NY 10017 166250 8758050 173729901 04/28/2026 Nasdaq Class A Common 02/05/2025 Stock Compensation Issuer N 40207 02/05/2025 Compensation Class A Common 01/31/2025 Stock Compensation Issuer N 92793 01/31/2025 Compensation Class A Common 09/14/2017 Direct Investment Issuer N 33250 09/14/2017 Cash N Eric Lefkofsky Care of Tempus AI, Inc 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common 02/18/2026 13587 802324 Blue Media, LLC Care of Tempus AI, Inc 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common 02/19/2026 133000 7830258 Blue Media, LLC Care of Tempus AI, Inc 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common 03/26/2026 133000 6169148.87 Gray Media, LLC Care of Tempus AI, Inc 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common 02/19/2026 33250 1957564 Gray Media, LLC Care of Tempus AI, Inc 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common 03/26/2026 33250 1542287.22 This form relates to sales by Blue Media, LLC (133,000 shares) and Gray Media, LLC (33,250 shares), of which Mr. Lefkofsky is the sole manager. 04/28/2026 03/04/2025 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Eric Lefkofsky