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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934
(Amendment No.  )
Filed by the Registrant ☒
Filed by a Party other than the Registrant ☐
Check the appropriate box:

☐ | Preliminary Proxy Statement

☐ | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☒ | Definitive Proxy Statement

☐ | Definitive Additional Materials

☐ | Soliciting Material under § 240.14a-12

Kalaris Therapeutics, Inc.
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check all boxes that apply):

☒ | No fee required

☐ | Fee paid previously with preliminary materials

☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

##### Table of Contents

KALARIS THERAPEUTICS, INC.

400 Connell Drive, Suite 5500

Berkeley Heights, New Jersey 07922

(650) 249-2727

NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS

To Be Held on Wednesday, June 3, 2026

Dear Stockholder:

You are cordially invited to the 2026 Annual Meeting of Stockholders, or the 2026 Annual Meeting, of Kalaris Therapeutics, Inc. The 2026 Annual Meeting will be held exclusively via the Internet in a virtual meeting format at www.proxydocs.com/KLRS on Wednesday, June 3, 2026 at 11:30 a.m., Eastern Time. At the meeting, the stockholders will consider and vote on the following matters:

| 1. | The election of three Class III directors, Napoleone Ferrara, M.D., David Hallal and Leone Patterson, each to serve for a three-year term expiring at the 2029 annual meeting of stockholders and until his or her respective successor has been duly elected and qualified;

| 2. | The approval of an advisory vote on executive compensation;

| 3. | The holding of an advisory vote on the frequency of future executive compensation advisory votes;

| 4. | The ratification of the selection of Deloitte & Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026; and

| 5. | The transaction of any other business that may properly come before the 2026 Annual Meeting or any adjournment or postponement thereof.

You may attend the 2026 Annual Meeting online at www.proxydocs.com/KLRS, where you will be able to vote your shares electronically during the meeting and submit questions during the meeting. Stockholders will not be able to attend the 2026 Annual Meeting in person and will be able to attend the meeting only via the webcast. In order to attend the 2026 Annual Meeting online, you must register in advance at www.proxydocs.com/KLRS prior to the commencement of the 2026 Annual Meeting. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the 2026 Annual Meeting and to vote and submit questions during the 2026 Annual Meeting. Please follow the instructions found on your Notice Regarding the Availability of Proxy Materials, proxy card and/or voting instruction card and other subsequent instructions that will be delivered to you via email.

Stockholders of record at the close of business on April 6, 2026 will be entitled to notice of and to vote at the 2026 Annual Meeting or any adjournment or postponement thereof.

A list of registered stockholders as of the close of business on the record date will be available for examination by any stockholder for any purpose germane to the 2026 Annual Meeting during normal business hours at our principal executive offices at 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922 during the 10-day period ending on the day before the 2026 Annual Meeting. We have elected to provide access to our proxy materials over the Internet under the Securities and Exchange Commission’s “notice and access” rules. We believe that providing our proxy materials over the Internet expedites stockholders’ receipt of proxy materials, lowers costs and reduces the environmental impact of our annual meeting. We are making this proxy statement, the related proxy card and our annual report to stockholders for the fiscal year ended December 31, 2025 available to stockholders for the first time on or about April 24, 2026.

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We encourage all stockholders to attend the 2026 Annual Meeting online. However, whether or not you plan to attend the 2026 Annual Meeting, we encourage you to read the proxy statement and submit your proxy or voting instructions as soon as possible. Please review the instructions on each of your voting options described in the proxy statement.

By the Order of the Board of Directors,

Andrew Oxtoby

President and Chief Executive Officer

Berkeley Heights, New Jersey

April 24, 2026

Important Notice Regarding Internet Availability of Proxy Materials for the 2026 Annual Meeting of Stockholders to be Held on June 3, 2026: The proxy materials and our 2025 Annual Report to Stockholders, which includes our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, are available at www.proxydocs.com/KLRS. These documents are also available to any stockholder who wishes to receive a paper copy by visiting www.proxydocs.com/KLRS, calling 1-866-648-8133 or emailing paper@investorelections.com. Any requests for a paper copy of these documents should be received by May 22, 2026, in order to ensure timely delivery.

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PROXY STATEMENT 2026 ANNUAL MEETING OF STOCKHOLDERS |  |  | 1 |
EXPLANATORY NOTE |  |  | 2 |
IMPORTANT INFORMATION ABOUT THE ANNUAL MEETING AND VOTING |  |  | 3 |
PROPOSAL NO. 1 ELECTION OF DIRECTORS |  |  | 10 |
Information Regarding Directors |  |  | 10 |
Recommendation of the Board of Directors |  |  | 14 |
Information Regarding the Board of Directors and Corporate Governance |  |  | 14 |
Corporate Governance Guidelines |  |  | 14 |
Director Independence |  |  | 14 |
Board Leadership Structure |  |  | 15 |
Board’s Role in Risk Oversight |  |  | 15 |
Director Nomination Process |  |  | 16 |
Communications with Our Board of Directors |  |  | 17 |
Board Meetings and Attendance |  |  | 18 |
Director Attendance at Annual Meeting |  |  | 18 |
Committees of Our Board of Directors |  |  | 18 |
Code of Business Conduct and Ethics |  |  | 20 |
Insider Trading Policy |  |  | 21 |
Policy on Trading, Pledging and Hedging of Company Stock |  |  | 21 |
Incentive Compensation Recoupment Policy |  |  | 21 |
Report of the Audit Committee of the Board of Directors |  |  | 22 |
PROPOSAL NO. 2 EXECUTIVE COMPENSATION |  |  | 23 |
PROPOSAL NO. 3 FREQUENCY OF EXECUTIVE COMPENSATION |  |  | 24 |
PROPOSAL NO. 4 RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM |  |  | 25 |
Independent Registered Public Accountants, Fees and Other Matters |  |  | 25 |
Pre-Approval Policies and Procedures |  |  | 26 |
Recommendation of the Board of Directors |  |  | 26 |
EXECUTIVE OFFICERS |  |  | 27 |
EXECUTIVE AND DIRECTOR COMPENSATION |  |  | 28 |
Executive Compensation |  |  | 28 |
Summary Compensation Table |  |  | 28 |
Narrative Disclosure to Summary Compensation Table |  |  | 29 |
Outstanding Equity Awards at 2025 Fiscal Year-End |  |  | 31 |
Employment Agreements and Other Arrangements |  |  | 32 |
401(k) Plan |  |  | 36 |
Policies and Practices Related to the Grant of Certain Equity Awards |  |  | 37 |
Director Compensation |  |  | 38 |
2025 Director Compensation Table |  |  | 38 |
Director Compensation Policy Prior to the Merger |  |  | 40 |
Director Compensation Policy Following the Merger |  |  | 40 |
Securities Authorized for Issuance Under Our Equity Compensation Plans |  |  | 42 |
Pay Versus Performance |  |  | 43 |
CERTAIN RELATED-PERSON TRANSACTIONS |  |  | 46 |
Legacy Kalaris Transactions |  |  | 46 |
2025 Private Placement |  |  | 49 |
Indemnification Agreements |  |  | 49 |
Policies and Procedures for Related Party Transactions |  |  | 50 |
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT |  |  | 51 |

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STOCKHOLDER PROPOSALS FOR OUR 2027 ANNUAL MEETING |  |  | 54 |
Stockholder Proposals Included in Proxy Statement |  |  | 54 |
Stockholder Proposals Not Included in Proxy Statement |  |  | 54 |
HOUSEHOLDING OF ANNUAL MEETING MATERIALS |  |  | 55 |
OTHER MATTERS |  |  | 56 |

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KALARIS THERAPEUTICS, INC.

400 Connell Drive, Suite 5500

Berkeley Heights, New Jersey

(650) 249-2727

PROXY STATEMENT

2026 ANNUAL MEETING OF STOCKHOLDERS

To Be Held on Wednesday, June 3, 2026

INFORMATION CONCERNING SOLICITATION AND VOTING

This proxy statement contains information about our 2026 Annual Meeting of Stockholders, or the Annual Meeting. The meeting will be held on Wednesday, June 3, 2026 at 11:30 a.m., Eastern Time. The Annual Meeting will be held exclusively via the Internet in a virtual meeting format at www.proxydocs.com/KLRS. There will not be a physical meeting location, and stockholders will not be able to attend the Annual Meeting in person. Except where the context otherwise requires, references to “Kalaris,” “the Company,” “we,” “us,” “our” and similar terms refer to Kalaris Therapeutics, Inc. References to our website are inactive textual references only and the contents of our website are not incorporated by reference into this proxy statement.

This proxy statement and the enclosed proxy card are being furnished in connection with the solicitation of proxies by our board of directors for use at the Annual Meeting and at any adjournment or postponement of that meeting. All proxies will be voted in accordance with the instructions they contain. If you do not specify your voting instructions, your proxy will be voted in accordance with the recommendations of our board of directors. We are making this proxy statement, the related proxy card and our annual report to stockholders for the fiscal year ended December 31, 2025, or our 2025 Annual Report, available to stockholders for the first time on or about April 24, 2026.

A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as filed with the Securities and Exchange Commission, or SEC, except for exhibits, will be furnished without charge to any stockholder upon written or oral request to Kalaris Therapeutics, Inc., 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922 or by calling 650-249-2727 or by emailing ir@kalaristx.com. This proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2025 are also available on the SEC’s website at www.sec.gov.

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EXPLANATORY NOTE

Prior to March 18, 2025, we were a late-stage clinical allogenic T cell immunotherapy company known as AlloVir, Inc., or AlloVir. On March 18, 2025, we completed our merger with privately held Kalaris Tx, Inc. (formerly Kalaris Therapeutics, Inc.), a Delaware corporation, or Legacy Kalaris, in accordance with the terms of the Agreement and Plan of Merger, dated as of November 7, 2024, or the Merger Agreement, that we entered into with Legacy Kalaris and Aurora Merger Sub, Inc., a Delaware corporation and our wholly owned subsidiary, or Merger Sub. Pursuant to the terms of the Merger Agreement, Merger Sub merged within and into Legacy Kalaris, with Legacy Kalaris continuing as our wholly owned subsidiary and the surviving corporation of the Merger, or the Merger.

At the closing of the Merger, we issued shares of our common stock to Legacy Kalaris securityholders (including holders of Legacy Kalaris convertible notes) based on an agreed upon exchange ratio, or the Exchange Ratio, each award of restricted shares of Legacy Kalaris common stock became exchangeable for the right to receive a number of shares of our restricted common stock based on the Exchange Ratio, and each option to purchase Legacy Kalaris common stock became an option to purchase our common stock, subject to adjustment in accordance with the Exchange Ratio.

Pursuant to the Merger Agreement, we changed our name from “AlloVir, Inc.” to “Kalaris Therapeutics, Inc.” Following the completion of the Merger, we became a clinical stage biopharmaceutical company dedicated to the development and commercialization of treatments for prevalent retinal diseases with major unmet medical needs. In connection with the closing of the Merger, our stock began trading on the Nasdaq Global Market under the symbol “KLRS.”

This proxy statement includes certain historical information relating to the AlloVir board of directors, executive officers and governance arrangements prior to the completion of the Merger. This proxy statement also includes certain disclosures concerning our board of directors and officers currently in office.

Unless otherwise noted, references to shares of common stock outstanding and per share amounts in this proxy statement give effect to a 1-for-23 reverse stock split of our common stock that became effective as of 4:05 p.m., Eastern Time, on January 15, 2025, or the Reverse Stock Split.

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IMPORTANT INFORMATION ABOUT THE ANNUAL MEETING AND VOTING

Q. | Why do I have access to these materials?

A. | We have made these proxy materials available to you because our board of directors is soliciting your proxy to vote at the Annual Meeting to be held on June 3, 2026 at 11:30 a.m., Eastern Time, including at any adjournments or postponements of the meeting. As a holder of common stock as of the close of business on April 6, 2026, you are invited to attend the Annual Meeting online and are requested to vote on the items of business described in this proxy statement. This proxy statement includes information that we are required to provide to you under the rules adopted by the SEC and that is designed to assist you in voting your shares.

Q. | Why did I receive a notice in the mail regarding the Internet availability of proxy materials instead of a full set of proxy materials?

A. | In accordance with SEC rules, we have elected to provide access to our proxy materials, including this proxy statement and our 2025 Annual Report, over the Internet. Accordingly, we plan to send a Notice Regarding the Availability of Proxy Materials, or the Notice, to our stockholders of record entitled to vote at the Annual Meeting with instructions for accessing the proxy materials. We plan to mail the Notice on or about April 24, 2026 to all stockholders entitled to vote at the Annual Meeting.

All stockholders entitled to vote at the Annual Meeting will have the ability to access the proxy materials by visiting the website referred to in the Notice, www.proxydocs.com/KLRS. This makes the proxy distribution process more efficient and less costly and helps conserve natural resources. The Notice also contains instructions on how to request to receive a printed set of the proxy materials. You may request a paper copy of the proxy materials by emailing paper@investorelections.com or by calling 1-866-648-8133. Any requests for a paper copy of the proxy materials should be received by May 22, 2026, in order to ensure timely delivery.

The Notice also identifies the date and time of, and web address for, the Annual Meeting; the matters to be acted upon at the meeting and our board of directors’ recommendation with regard to each matter; a toll-free telephone number and an e-mail address for stockholders to request to receive, free of charge, a paper or e-mail copy of the proxy statement, our 2025 Annual Report, and a form of proxy card relating to the Annual Meeting; and information on how to access and vote the form of proxy card.

Q. | Can I vote my shares by filling out and returning the Notice?

A. | No. The Notice identifies the items to be voted on at the Annual Meeting, but you cannot vote by marking the Notice and returning it. The Notice provides instructions on how to vote over the Internet or by telephone or by requesting and returning a printed proxy card. The Notice also provides instructions on how to register to vote online during the Annual Meeting.

Q. | What does it mean if I receive more than one Notice?

A. | If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on the Notices to ensure that all of your shares are voted.

Q. | What is the purpose of the Annual Meeting?

A. | At the Annual Meeting, stockholders will consider and vote on the following matters:

| (1) | The election of three Class III directors, Napoleone Ferrara, M.D., David Hallal and Leone Patterson, each to serve for a three-year term expiring at the 2029 annual meeting of stockholders and until his or her respective successor has been duly elected and qualified (Proposal No. 1).

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| (2) | The approval of an advisory vote on executive compensation (Proposal No. 2).

| (3) | The holding of an advisory vote on the frequency of future executive compensation advisory votes (Proposal No. 3).

| (4) | The ratification of the selection of Deloitte & Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026 (Proposal No. 4).

| (5) | The transaction of any other business that may properly come before the Annual Meeting or any adjournment or postponement thereof.

Q. | Why is the Annual Meeting of stockholders a virtual, online meeting?

A. | The Annual Meeting will be held as a virtual meeting of stockholders where stockholders will participate by accessing a website using the Internet. There will not be a physical meeting location. We believe that hosting a virtual meeting will enable greater stockholder attendance and participation from any location around the world. We have designed the format of the Annual Meeting to provide stockholders substantially the same rights and opportunities to participate as they would have at an in-person meeting.

Q. | How do I virtually attend the Annual Meeting?

A. | We will host the Annual Meeting live online via webcast. In order to attend the Annual Meeting online, you must register at www.proxydocs.com/KLRS prior to the commencement of the Annual Meeting. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the Annual Meeting and to vote and submit questions during the Annual Meeting. Please follow the instructions found on your Notice, proxy card and/or voting instruction card and other subsequent instructions that will be delivered to you via email. Online registration for the Annual Meeting will begin on or around April 24, 2026.

The webcast of the Annual Meeting will start at 11:30 a.m., Eastern Time, on Wednesday, June 3, 2026. Instructions on how to attend and participate in the meeting online will be sent to you via email, upon completing your registration.

We will have technicians ready to assist you with any technical difficulties you may have accessing the Annual Meeting. If you encounter any difficulty accessing, or during, the Annual Meeting, please call the support team at the numbers listed on the web portal at the time of the Annual Meeting.

Q. | Who can vote?

A. | Only stockholders of record at the close of business on April 6, 2026, the record date for the Annual Meeting, are entitled to vote at the Annual Meeting. On this record date, there were 22,992,291 shares of our common stock outstanding. Common stock is our only class of stock outstanding.

Q. | How many votes do I have?

A. | Each share of our common stock that you own as of the record date, April 6, 2026, entitles you to one vote on each matter that is voted on.

Q. | Is my vote important?

A. | Your vote is important no matter how many shares you own. Please take the time to vote. Take a moment to read the instructions, choose the way to vote that is the easiest and most convenient for you and cast your vote as soon as possible.

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Q. | How do I vote?

A. | If you are the “record holder” of your shares, meaning that you own your shares in your own name and not through a bank, brokerage firm or other nominee, you may vote:

(1) Over the Internet: To vote over the Internet prior to the Annual Meeting, please go to the following website: www.proxypush.com/KLRS, and follow the instructions at that site for submitting your proxy electronically. If you vote over the Internet, you do not need to complete and mail your proxy card or vote your proxy by telephone. Your vote must be received by 11:59 p.m., Eastern Time, on June 2, 2026 to be counted.

(2) By Telephone: To vote by telephone, please call 1-866-314-3599, and follow the instructions provided on the proxy card. If you vote by telephone, you do not need to complete and mail your proxy card or vote your proxy over the Internet. Your vote must be received by 11:59 p.m., Eastern Time, on June 2, 2026 to be counted.

(3) By Mail: To vote by mail, you must request printed proxy materials, including a proxy card, and complete, sign and date the proxy card and return it promptly in the postage prepaid envelope provided. If you vote by mail, you do not need to vote over the Internet or by telephone. Your proxy card must be received by June 2, 2026 to be counted.

(4) Online During the Annual Meeting: You may attend and vote at the Annual Meeting online at www.proxydocs.com/KLRS, where you will be able to vote electronically during the Annual Meeting. In order to attend, you must register at www.proxydocs.com/KLRS prior to the commencement of the Annual Meeting. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the Annual Meeting and to vote and submit questions during the Annual Meeting. If you vote by proxy prior to the Annual Meeting and choose to attend the Annual Meeting online, there is no need to vote again during the Annual Meeting unless you wish to change your vote.

If your shares are held in “street name,” meaning they are held for your account by an intermediary, such as a bank, brokerage firm or other nominee, then you are deemed to be the beneficial owner of your shares and the bank, brokerage firm or other nominee that actually holds the shares for you is the record holder and is required to vote the shares it holds on your behalf according to your instructions. The proxy materials, as well as voting instructions, should have been forwarded to you by the bank, brokerage firm or other nominee that holds your shares. In order to vote your shares, you will need to follow the instructions that your bank, brokerage firm or other nominee provides you. Many brokerage firms solicit voting instructions over the Internet or by telephone.

You are welcome to virtually attend the Annual Meeting if your shares are held in street name, however, you must register in advance at www.proxydocs.com/KLRS. You must also obtain a legal proxy executed in your favor from the holder of record (i.e., your bank, brokerage firm or other nominee) to vote shares held in street name during the Annual Meeting. A legal proxy is not the form of proxy included with this proxy statement. If you hold your shares in “street name,” you must request a legal proxy from your bank, brokerage firm or other nominee to vote during the Annual Meeting. Further instructions will be provided to you as part of your registration process.

Q. | Can I change my vote?

A. | If you are the “record holder” of your shares, you may revoke your proxy and change your vote by following one of the below procedures:

(1) Vote over the Internet or by telephone as instructed above under “Over the Internet” and “By Telephone.” Only your latest Internet or telephone vote is counted. You may not change your vote over the Internet or by telephone after 11:59 p.m., Eastern Time, on June 2, 2026.

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(2) Sign and complete a new proxy card and send it by mail in the postage prepaid envelope provided. BetaNXT, Inc. must receive the proxy card no later than June 2, 2026. Only your latest dated proxy card will be counted.

(3) Virtually attend the Annual Meeting online and vote online as instructed above, which will have the effect of revoking any previously submitted proxy. Attending the Annual Meeting alone will not revoke your Internet vote, telephone vote or proxy submitted by mail, as the case may be.

(4) Give our Secretary written notice before the Annual Meeting that you want to revoke your proxy. Such written notice should be sent to Kalaris Therapeutics, Inc., Attention: Secretary, 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922.

If your shares are held in “street name,” you may submit new voting instructions with a later date by contacting your bank, brokerage firm or other nominee and following their instructions. You may also vote virtually at the Annual Meeting, which will have the effect of revoking any previously submitted voting instructions, if you obtain a legal proxy as described in the answer to the question “How do I vote?” above.

Attending the Annual Meeting alone will not revoke your proxy.

Q. | Will my shares be voted if I do not return my proxy?

A. | If your shares are registered directly in your name, your shares will not be voted if you do not vote over the Internet, by telephone or by returning your proxy card by mail or online while virtually attending the Annual Meeting.

If your shares are held in “street name,” your brokerage firm may under certain circumstances vote your shares if you do not return your voting instructions. Brokerage firms can vote customers’ unvoted shares on discretionary matters but they are not allowed to vote your shares with respect to certain non-discretionary items. If you do not return voting instructions to your brokerage firm to vote your shares, your brokerage firm may, on discretionary matters, either vote your shares or leave your shares unvoted.

Proposal No. 1, the election of three Class III directors, Proposal No. 2, the advisory vote on executive compensation, and Proposal No. 3, the advisory vote on the frequency of future executive compensation advisory votes, are not considered discretionary matters. If you do not instruct your brokerage firm how to vote with respect to these proposals, your brokerage firm may not vote your shares with respect to these proposals and your shares instead will be counted as “broker non-votes” with respect to these proposals. “Broker non-votes” occur when your bank, brokerage firm or other nominee submits a proxy for your shares (because the bank, brokerage firm or other nominee has received instructions from you on one or more proposals, but not all proposals, or has not received instructions from you but is entitled to vote on a particular “discretionary” matter) but does not indicate a vote for a particular proposal because the bank, brokerage firm or other nominee either does not have the authority to vote on that proposal and has not received voting instructions from you or has discretionary authority but chooses not to exercise it. Proposal No. 4, the ratification of the selection of Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026, is considered a discretionary matter. If you do not instruct your brokerage firm how to vote with respect to this proposal, your brokerage firm may vote your shares on this proposal even if it does not receive instructions from you, so long as it holds your shares in its name. We encourage you to provide voting instructions to your brokerage firm or other nominee. This ensures that your shares will be voted at the Annual Meeting according to your instructions. You should receive directions from your brokerage firm or other nominee about how to submit your voting instructions.

Q. | How many shares must be represented to hold the Annual Meeting?

A. | A quorum is needed to hold a valid Annual Meeting. A quorum will be present if the holders of a majority of the shares of our common stock entitled to vote at the Annual Meeting are present at the virtual Annual Meeting either “in person” virtually or represented by proxy. For purposes of determining whether a quorum exists, we count as present any shares that are voted over the Internet, by telephone, by mail or virtually at

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| the Annual Meeting. Further, for purposes of establishing a quorum, we will count as present shares that a stockholder holds even if the stockholder votes to abstain or only votes on one of the proposals. In addition, we will count as present shares that are counted as broker non-votes. If a quorum is not present, we expect to adjourn the Annual Meeting until we obtain a quorum.

The presence at the Annual Meeting, virtually or by proxy, of holders representing a majority of the outstanding shares of our common stock as of the record date, April 6, 2026, or approximately 11,496,146 shares, constitutes a quorum at the meeting and permits us to conduct the business of the meeting.

Q. | What vote is required to approve each matter and how are votes counted?

A. | Proposal No. 1-Election of Directors

A nominee will be elected as a director at the Annual Meeting if the nominee receives FOR votes representing a plurality of the votes properly cast on the election of directors. You may:

| • |  | vote FOR all nominees;

| • |  | vote FOR one or more nominees and WITHHOLD your vote from the other nominees; or

| • |  | WITHHOLD your vote from all nominees.

Votes that are withheld and broker non-votes will not be included in the vote tally for the election of directors and will not affect the results of the vote.

Proposal No. 2-Advisory Vote on Executive Compensation

The affirmative vote of the holders of shares of our common stock representing a majority of the votes properly cast on the matter is required for approval of the advisory vote on executive compensation. Abstentions and broker non-votes (if any) will not be counted as votes cast on this matter and, as a result, will have no effect on the outcome of Proposal No. 2.

As described in more detail in Proposal No. 2, because this proposal is non-binding, our board of directors may decide that it is in our and our stockholders’ best interests to compensate our named executive officers in an amount or manner that differs from that which is approved by our stockholders.

Proposal No. 3-Advisory Vote on the Frequency of Future Executive Compensation Advisory Votes

The affirmative vote of the holders of shares of our common stock representing a majority of the votes properly cast on the matter is required for approval of one of the three frequency options (one year, two years or three years) under the advisory vote on the frequency of future executive compensation advisory votes. Abstentions and broker non-votes (if any) will not be counted as votes cast on this matter and, as a result, will have no effect on the outcome of Proposal No. 3.

With respect to Proposal No. 3, if none of the three frequency options receives the affirmative vote of the holders of shares of our common stock representing a majority of the votes properly cast, we will consider the frequency option (one year, two years or three years) receiving the highest number of votes cast by stockholders to be the frequency that has been recommended by stockholders. However, as described in more detail in Proposal No. 3, because this proposal is non-binding, our board of directors may decide that it is in our and our stockholders’ best interests to hold future executive compensation advisory votes more or less frequently than the option approved by our stockholders.

Proposal No. 4-Ratification of Selection of Independent Registered Public Accounting Firm

The affirmative vote of the holders of shares of our common stock representing a majority of the votes properly cast on the matter is required for the ratification of the selection of Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026. Abstentions

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and broker non-votes (if any) will not be counted as votes cast on this matter and, as a result, will have no effect on the outcome of Proposal No. 4.

Although stockholder approval of our audit committee’s selection of Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026 is not required, we believe that it is advisable to give stockholders an opportunity to ratify this selection. If this proposal is not approved at the Annual Meeting, our audit committee will reconsider its selection of Deloitte and Touche LLP as our independent registered public accounting firm for the year ending December 31, 2026.

Q. | How does the board of directors recommend that I vote on the proposals?

A. | Our board of directors recommends that you vote:

| • |  | FOR the election of each of the Class III directors, Napoleone Ferrara, M.D., David Hallal and Leone Patterson, each to serve for a three-year term expiring at the 2029 annual meeting of stockholders and until his or her respective successor is duly elected and qualified; and

| • |  | FOR the approval of the advisory vote on executive compensation;

| • |  | FOR the approval, on an advisory basis, of holding future executive compensation advisory votes every ONE YEAR;

| • |  | FOR the ratification of the selection of Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026.

Q. | Are there other matters to be voted on at the Annual Meeting?

A. | We do not know of any matters that may come before the Annual Meeting other than the election of our directors, the advisory vote on executive compensation, the advisory vote on the frequency of future executive compensation advisory votes, and the ratification of the selection of Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026. If any other matters are properly presented at the Annual Meeting, the persons named in the accompanying proxy intend to vote, or otherwise act, in accordance with their judgment on the matter.

Q. | Who will count the votes?

A. | The votes will be counted, tabulated and certified by BetaNXT, Inc.

Q. | How can I find out the results of the voting at the Annual Meeting?

A. | Preliminary voting results will be announced at the Annual Meeting. Final voting results will be tallied by the inspector of election and published in a Current Report on Form 8-K to be filed with the SEC within four business days after the Annual Meeting.

Q. | How do I submit a question at the Annual Meeting?

A. | If you wish to submit a question prior to the Annual Meeting, you must register to attend the Annual Meeting. You can visit www.proxydocs.com/KLRS and follow the instructions for registering to attend the Annual Meeting and for submitting a question. If you wish to submit a question during the Annual Meeting, you may log into the virtual meeting platform using the link provided to you via email following the completion of your registration process. Our virtual meeting will be governed by our Rules of Conduct and Procedures, which will be posted at www.proxydocs.com/KLRS during the meeting.

Q. | How and when may I submit a stockholder proposal, including a stockholder nomination for director for the 2027 annual meeting?

A. | Stockholders who wish to recommend individuals for consideration by the nominating and corporate governance committee to become nominees for election to our board of directors may do so by delivering a

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| written recommendation to the Secretary at 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922 not later than the close of business on the 90th day, nor earlier than the close of business on the 120th day, prior to the one-year anniversary of the preceding year’s annual meeting. Submissions must include all information relating to such person that is required to be disclosed in solicitations of proxies for election of directors in an election contest, or is otherwise required, in each case pursuant to Regulation 14A under the Securities Exchange Act of 1934, as amended, or the Exchange Act (including such person’s written consent to being named in the proxy statement as a nominee and to serving as a director if elected). We may require any proposed nominee to furnish such other information as we may reasonably require in determining the eligibility of such proposed nominee to serve as an independent director or that could be material to a reasonable stockholder’s understanding of the independence, or lack thereof, of such proposed nominee.

Q. | Who is paying the costs of soliciting these proxies?

A. | We will pay all of the costs of soliciting proxies. Our directors, officers and other employees may solicit proxies in person or by mail, telephone, fax or email. We will pay our directors, officers and other employees no additional compensation for these services. We will ask banks, brokerage firms and other nominees to forward these proxy materials to their principals and to obtain authority to execute proxies. We may reimburse them for their expenses.

Q. | Whom should I contact if I have any questions?

A. | If you have any questions about the Annual Meeting or your ownership of our common stock, please contact Kalaris Therapeutics, Inc. at 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922, telephone: (650) 249-2727, e-mail: ir@kalaristx.com.

Implications of Being a “Smaller Reporting Company”

We are a “smaller reporting company,” meaning that the market value of our stock held by non-affiliates was less than $700 million as of the last business day of our most recently completed second fiscal quarter and our annual revenue was less than $100 million during our most recently completed fiscal year. We may continue to be a smaller reporting company if either (i) the market value of our stock held by non-affiliates is less than $250 million or (ii) our annual revenue was less than $100 million during the most recently completed fiscal year and the market value of our stock held by non-affiliates is less than $700 million. For so long as we remain a smaller reporting company, we are permitted and intend to rely on exemptions from certain disclosure and other requirements that are applicable to other public companies that are not applicable to a smaller reporting company. Under the scaled disclosure obligations available to smaller reporting companies, we are not required to provide, among other things, Compensation Discussion and Analysis and certain other tabular and narrative disclosures relating to executive compensation. We have taken advantage of certain reduced reporting obligations in this proxy statement. Accordingly, the information contained herein may be different than the information you receive from other public companies in which you hold stock.

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PROPOSAL NO. 1 ELECTION OF DIRECTORS

In accordance with the terms of our restated certificate of incorporation and amended and restated by-laws, our board of directors is divided into three classes, Class I, Class II and Class III, with members of each class serving staggered three-year terms. As a result, only one class of our directors is elected at each annual meeting of stockholders, with the other classes continuing for the remainder of their respective three-year terms. Vacancies on our board of directors may be filled by persons elected solely by the affirmative vote of a majority of the remaining directors. A director elected by our board of directors to fill a vacancy in a class, including vacancies created by an increase in the number of directors, shall serve for the remainder of the full term of that class and until the director’s successor is duly elected and qualified.

Our board of directors currently consists of eight members. The members of the classes are divided as follows:

| • |  | the Class I directors are Anthony P. Adamis, M.D., Michael Dybbs, Ph.D. and Morana Jovan-Embiricos, Ph.D., and their term will expire at the annual meeting of stockholders to be held in 2027;

| • |  | the Class II directors are Srinivas Akkaraju, M.D., Ph.D. and Andrew Oxtoby, and their term will expire at the annual meeting of stockholders to be held in 2028; and

| • |  | the Class III directors are Napoleone Ferrara, M.D., David Hallal and Leone Patterson, and their term expires at the Annual Meeting.

Our board of directors has nominated Napoleone Ferrara, M.D., David Hallal and Leone Patterson for election as directors at the Annual Meeting. Each of Dr. Ferrara, Mr. Hallal and Ms. Patterson is presently a director and has indicated a willingness to continue to serve as director, if elected. Unless otherwise instructed, proxies will be voted for Dr. Ferrara, Mr. Hallal and Ms. Patterson. In the event that Dr. Ferrara, Mr. Hallal or Ms. Patterson is not a candidate or is unable to serve as a director at the time of the election (which is not currently expected), your proxy will be voted for any nominee who is designated by our board of directors to fill the vacancy. Upon closing of the Merger, Dr. Ferrara was appointed and Mr. Hallal was re-appointed to our board of directors, and in April 2025, Ms. Patterson was appointed to our board of directors. Mr. Hallal previously stood for election as a director of AlloVir in 2023. Each of Dr. Ferrara and Ms. Patterson are standing for election by our stockholders for the first time at the Annual Meeting.

Information Regarding Directors

The following paragraphs provide biographical information as of April 24, 2026, including principal occupation and business experience during the last five years, for each director, including each nominee for director at the Annual Meeting.

Information about the number of shares of common stock beneficially owned by each of our directors, including each nominee for director, appears below under the heading “Security Ownership of Certain Beneficial Owners and Management.”

There are no family relationships between or among any of our executive officers or directors, including each nominee for director.

Class III Director Nominees, Term Expiring at the 2029 Annual Meeting of Stockholders, if elected

Napoleone Ferrara, M.D., age 69, has served as a member of our board of directors and as a consultant to the company since the closing of the Merger. Prior to the closing of the Merger, Dr. Ferrara had served as a member of the Legacy Kalaris board of directors since September 2019. Dr. Ferrara also served as a consultant of Legacy Kalaris since 2021. Dr. Ferrara previously served as a director of TuHURA Biosciences, Inc. (formerly, DelMar Pharmaceuticals, Inc.) from June 2018 to August 2020. Since January 2013 he has served as a professor of pathology and since July 2014 as an adjunct professor of ophthalmology and pharmacology at the University of

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California, San Diego. Previously, Dr. Ferrara held increasingly senior positions at Genentech, Inc. (now a wholly owned member of The Roche Group), over a 24-year period, including Genentech fellow, staff scientist and senior scientist. He is a pioneer in the study of angiogenesis biology and identification of its regulators. Dr. Ferrara’s lab is responsible for discovering the isolation and cDNA cloning of VEGF and demonstrated that VEGF was a major mediator of tumor angiogenesis leading to the development of Avastin® (bevacizumab). Additionally, his lab’s studies led to the clinical development of an anti-VEGF antibody fragment, Lucentis® (ranibizumab), as a highly effective therapy preventing vision loss in intraocular neovascular disorders. Dr. Ferrara has been the recipient of over 60 awards/honors, including the Lasker Award and Champalimaud Vision Award, given more than 300 presentations, authored over 70 patents, and written more than 300 articles, reviews/editorials and published book chapters. Dr. Ferrara is a member of the National Academy of Sciences and the National Academy of Medicine, USA. He is a member of the scientific advisory boards of several biotechnology companies. He received his fellowship training and postdoctoral research from the University of California, San Francisco, his M.D. (cum laude) and residency training from the University of Catania Medical School, and his Maturità Classica from Liceo Classico Mario Cutelli. We believe Dr. Ferrara is qualified to serve as a member of our board of directors due to his medical training and extensive knowledge and experience in the fields of ophthalmology, pharmacology and angiogenesis.

David Hallal, age 59, has served as Chairman of our board of directors since the closing of the Merger. Prior to the closing of the Merger, Mr. Hallal served as our Executive Chairman from May 2021 until the closing of the Merger and previously served as our Chief Executive Officer and Chairman from September 2018 to May 2021. Mr. Hallal has served as the chief executive officer of Scholar Rock Holding Corp., a publicly traded company, or Scholar Rock, since April 2025 and has served as the chairman of the board of directors of Scholar Rock since May 2017. Mr. Hallal serves as the executive chairman of ElevateBio LLC, or ElevateBio, where he served as chairman, chief executive officer and co-founder of ElevateBio from December 2017 until April 2025. Prior to that, Mr. Hallal served in executive roles of increasing responsibility at Alexion Pharmaceuticals, Inc., or Alexion, a publicly traded company, most recently serving as chief executive officer and a board member. Prior to his role as chief executive officer, Mr. Hallal served Alexion as chief operating officer and a board member as well as chief commercial officer and head of commercial operations. Mr. Hallal holds a B.A. in psychology from the University of New Hampshire. We believe Mr. Hallal is qualified to serve as a member of our board of directors due to his experience as an executive at numerous pharmaceutical companies.

Leone Patterson, age 63, has served as a member of our board of directors since April 2025. Ms. Patterson previously served as executive vice president, chief business officer and chief financial officer of Zymeworks Inc., a publicly traded clinical-stage biotechnology company, from July 2024 to January 2026. Prior to Zymeworks Inc., Ms. Patterson served as chief financial officer and chief business officer of Tenaya Therapeutics, Inc., a publicly traded clinical-stage biotechnology company, from June 2021 to July 2024. Prior to joining Tenaya Therapeutics, Inc., Ms. Patterson held several roles at Adverum Biotechnologies, Inc., a publicly traded clinical-stage gene therapy company, including chief financial officer from June 2016 to May 2018, chief executive officer from May 2018 to June 2022, and president from December 2019 to May 2021. Ms. Patterson has held various senior positions at Diadexus, Inc., a biotechnology company, Transcept Pharmaceuticals, Inc., a pharmaceutical company, NetApp, Inc., a publicly traded data infrastructure company, Exelixis, Inc., a publicly traded genomics-based drug discovery company, Novartis AG, a publicly traded pharmaceutical company, Chiron Corporation (acquired by Novartis AG), and KPMG. Diadexus, Inc. voluntarily filed for Chapter 7 bankruptcy in June 2016 while Ms. Patterson was its chief financial officer. Ms. Patterson currently serves on the board of directors and as the chair of the audit committee of Nkarta, Inc., or Nkarta, a publicly traded biotechnology company. Ms. Patterson previously served on the board of directors and as a member of the audit committee of Oxford Biomedica (UK) Limited, a publicly traded contract development and manufacturing organization focused on cell and gene therapy, from May 2023 until December 2024, on the board of directors, chair of the audit committee and member of the nominating and corporate governance committee of Eliem Therapeutics, Inc. (now known as Climb Bio, Inc.), a publicly traded biotechnology company, from June 2020 to January 2023, and on the board of directors of Adverum Biotechnologies, Inc. from October 2018 to June 2020. Ms. Patterson holds a B.S. in Business Administration and Accounting from Chapman University and an

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Executive M.B.A. from St. Mary’s College. Ms. Patterson is also a Certified Public Accountant (inactive status). We believe Ms. Patterson is qualified to serve as member of our board of directors due to her financial expertise and her extensive experience in the biotechnology industry, including her leadership and management experience.

Class I Directors Continuing in Office Until the 2027 Annual Meeting of Stockholders

Anthony P. Adamis, M.D., age 67, has served as a member of our board of directors since the closing of the Merger. Prior to the closing of the Merger, Dr. Adamis had served as a member of the Legacy Kalaris board of directors since November 2021. Since July 2024, Dr. Adamis has served as chief scientific officer of Eyebiotech Limited, or EyeBio, an ophthalmology biotechnology subsidiary of Merck & Co., Inc., or Merck. Previously, Dr. Adamis served as the co-founder and a director for EyeBio prior to its acquisiton by Merck & Co., Inc., from August 2021 to July 2024, where he also served as its chief scientific officer from August 2022 to July 2024. From April 2023 to January 2024, Dr. Adamis served as co-founder and chief scientific officer at Aiolos Bio, Inc., a biopharmaceutical company that was acquired by GSK plc. He served as the chief executive officer and chief scientific officer at Tier1 Bio Ltd., a private biotechnology company, from January 2021 to March 2023. Dr. Adamis has served as a director of Spiral Therapeutics, Inc., a privately held non-ophthalmic biotechnology company since October 2021, as a director of Cellio Therapeutics, a privately held ophthalmic biotechnology company since January 2025, and as a director for the RD Fund, the venture arm of the Foundation Fighting Blindness since October 2021. Previously, Dr Adamis served as a director for EyePoint Pharmaceuticals, Inc. from June 2022 to August 2024 and as a director for Gyroscope Therapeutics Holdings plc, a clinical-stage gene therapy company focused on diseases of the eye, from 2021 until its acquisition by Novartis AG in 2022. He also served as vice president and senior vice president of Development at Genentech, Inc. (now a wholly owned member of The Roche Group) from 2009 to 2021. Dr. Adamis was previously co-founder and chief scientific officer of Eyetech Pharmaceuticals, Inc., which developed the first U.S. Food and Drug Administration, or FDA, approved anti-VEGF agent (Macugen®) for the treatment of nAMD and was acquired by OSI Pharmaceuticals, Inc. (now Takeda Pharmaceuticals Company Limited). He is best known for his co-discovery of the central role of vascular endothelial growth factor (VEGF) in two leading causes of blindness: neovascular age-related macular degeneration (nAMD) and diabetic retinopathy. Conducted at Harvard in the 1990s, this research led to Dr. Adamis’ shared receipt of the Antonio Champalimaud Award, the highest honor in vision science, and to his election to the National Academy of Medicine. Over the course of his career, Dr. Adamis has helped develop 20 medicines across 30 indications, resulting in seven FDA Breakthrough Designations and 32 FDA approvals. Dr. Adamis received his M.D. from the University of Chicago, his ophthalmology training at the University of Michigan, and his fellowship training at Harvard University. Dr. Adamis completed his research training in vascular biology with Judah Folkman, M.D., at Boston Children’s Hospital. We believe Dr. Adamis is qualified to serve as a member of our board of directors due to his extensive leadership experience, his extensive experience in ophthalmology and in the life sciences industry, and his extensive service on the board of other public and private life sciences companies.

Michael Dybbs, Ph.D., age 51, has served as a member of our board of directors since the closing of the Merger. Prior to the closing of the Merger, Dr. Dybbs had served as a member of the Legacy Kalaris board of directors since March 2022. Dr. Dybbs is currently a partner at Samsara BioCapital L.P., or Samsara LP, a venture capital firm, where he has worked since March 2017. Prior to joining Samsara LP, Dr. Dybbs was a partner at New Leaf Venture Partners, where he worked from May 2009 until September 2016. Before joining New Leaf Venture Partners, Dr. Dybbs was a principal at the Boston Consulting Group from August 2005 to May 2009. Dr. Dybbs has served as a member of the Sutro Biopharma, Inc. board of directors since July 2018. He also has served on the board of directors of Nkarta since August 2019, and on the boards of directors of several private companies. Dr. Dybbs received an A.B. in Biochemical Sciences from Harvard College and a Ph.D. in Molecular Biology from University of California, Berkeley, where he was awarded a Howard Hughes Medical Institute fellowship. We believe that Dr. Dybbs is qualified to serve as a member of our board of directors due to his experience in the life sciences industry and the venture capital industry, and his leadership and management experience.

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Morana Jovan-Embiricos, Ph.D., age 59, has served as a member of our board of directors since May 2019. In 2003, Dr. Jovan co-founded F2 Ventures, a biotech venture capital platform, and has since served as its managing partner. Prior to joining F2 Ventures, Dr. Jovan was a partner at MPM Capital. Dr. Jovan currently serves on the boards of directors of Damon Runyon Cancer Center Research Foundation and ElevateBio and previously served on the board of directors at Cullinan Therapeutics, Inc. (formerly, Cullinan Oncology, Inc.) and TCR2 Therapeutics Inc., each a publicly traded company. Dr. Jovan received her Ph.D. in biophysical chemistry from the University of Cambridge and was a post-doctoral fellow at Harvard University. We believe Dr. Jovan is qualified to serve as a member of our board of directors because of her scientific background and experience in the venture capital industry.

Class II Directors Continuing in Office Until the 2028 Annual Meeting of Stockholders

Srinivas Akkaraju, M.D., Ph.D., age 58, has served as a member of our board of directors since the closing of the Merger. Prior to the closing of the Merger, Dr. Akkaraju had served as a member of the Legacy Kalaris board of directors since September 2019. Dr. Akkaraju has been a founder and managing general partner at Samsara LP since March 2017. Previously, from April 2013 to February 2016, he served as a general partner of Sofinnova Ventures. From January 2009 until April 2013, he served as managing director of New Leaf Venture Partners. He also previously served as a managing director at Panorama Capital, LLC, or Panorama Capital, a private equity firm. Prior to co-founding Panorama Capital, he was with J.P. Morgan Partners, which he joined in 2001 and of which he became a partner in 2005. From October 1998 to April 2001, he was in Business and Corporate Development at Genentech, Inc. (now a wholly owned member of The Roche Group), a biotechnology company, most recently as senior manager. Dr. Akkaraju has been a member of the board of directors for vTv Therapeutics Inc., since February 2024, Scholar Rock, since July 2022, Mineralys Therapeutics, Inc., since February 2021, Inventiva S.A., since December 2024, and Alumis Inc., since January 2021. Dr. Akkaraju previously served as a director of Chinook Therapeutics, Inc., or Chinook, from October 2020 to August 2023, Syros Pharmaceuticals, Inc., from June 2017 to November 2024, Intercept Pharmaceuticals, Inc., from October 2012 to November 2023, Jiya Acquisition Corp., from November 2020 to November 2022, Seattle Genetics, Inc. (now, Seagen Inc.), from July 2003 to August 2020, and Principia Biopharma Inc., from February 2011 to June 2019. Dr. Akkaraju was a graduate student at Stanford University, where he received his M.D. and a Ph.D. in Immunology. He received his undergraduate degrees in Biochemistry and Computer Science from Rice University. We believe Dr. Akkaraju is qualified to serve as a member of our board of directors due to his strong scientific background and extensive experience in private equity and venture capital investing.

Andrew Oxtoby, age 52, has served as our President and Chief Executive Officer and as a member of our board of directors since the closing of the Merger. Prior to the closing of the Merger, Mr. Oxtoby had served as Legacy Kalaris’ President and Chief Executive Officer and as a member of the Legacy Kalaris board of directors since March 2024. Prior to joining Legacy Kalaris, Mr. Oxtoby served as chief commercial officer of Chinook, a biotechnology company that was acquired by Novartis AG, from February 2023 to September 2023. Prior to that, Mr. Oxtoby served as president and chief executive officer of Aimmune Therapeutics, Inc., a biotechnology company, following their acquisition by Nestle Health Science, from October 2020 to January 2023 and as its chief commercial officer from January 2019 to September 2020 prior to the company’s acquisition. Prior to that, Mr. Oxtoby spent 16 years at Eli Lily and Company, a pharmaceutical company, where he held various leadership positions, including most recently as vice president of U.S. Connected Care & Insulins from May 2018 to December 2018. Mr. Oxtoby received a B.S. in Mechanical Engineering from Purdue University and a M.B.A. from Harvard Business School. Mr. Oxtoby has served as a member of the board of directors of Aravax Pty Ltd., a privately held clinical stage biotechnology company, since April 2026. We believe Mr. Oxtoby is qualified to serve as a member of our board of directors due to his extensive knowledge of Legacy Kalaris based on his former role as its President and Chief Executive Officer, as well as his significant biopharmaceutical industry and management experience.

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Recommendation of the Board of Directors

OUR BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE ELECTION OF EACH OF DR. FERRARA, MR. HALLAL AND MS. PATTERSON.

Information Regarding the Board of Directors and Corporate Governance

We believe that good corporate governance is important to ensure that our company is managed for the long-term benefit of our stockholders. This section describes key corporate governance practices that we have adopted. Complete copies of our corporate governance guidelines, committee charters for all committees and code of business conduct and ethics are available on the “Investors & Press - Corporate Governance” section of our website, www.kalaristx.com. We will also provide copies of these documents, free of charge, to any stockholder upon written request to Attention: Investor Relations, Kalaris Therapeutics, Inc., 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922, telephone: (650) 249-2727, email: ir@kalaristx.com.

Corporate Governance Guidelines

Our board of directors has adopted corporate governance guidelines to assist in the exercise of its duties and responsibilities and to serve the best interests of Kalaris and our stockholders. These guidelines, which provide a framework for the conduct of our board of directors’ business, provide that:

| • |  | our board of directors’ responsibility is to manage or direct our business and affairs;

| • |  | at least a majority of the members of our board of directors shall be independent directors, subject to any applicable exceptions contained in the rules of the Nasdaq Stock Market, or Nasdaq;

| • |  | the independent directors will meet at least twice annually in executive session;

| • |  | our board of directors shall be entitled to rely on the advice and information that it receives from management and such experts, advisors and professionals with whom the board of directors, or any committee of our board of directors, may consult; and

| • |  | our board of directors may conduct a self-evaluation periodically to determine whether it and its committees are functioning effectively.

Director Independence

Nasdaq rules generally require a majority of a listed company’s board of directors to be comprised of independent directors within one year of listing. In addition, Nasdaq rules generally require that audit committee members must also satisfy the independence criteria set forth in Rule 10A-3 under the Exchange Act, and Nasdaq rules generally require that compensation committee members must also satisfy the independence criteria set forth in Rule 10C-1 under the Exchange Act. Under applicable Nasdaq rules, a director will only qualify as an “independent director” if, in the opinion of the listed company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. In order to be considered independent for purposes of Rule 10A-3, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the board of directors, or any other board committee, accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed company or any of its subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries. In order to be considered independent for purposes of Rule 10C-1, the board must consider, for each member of a compensation committee of a listed company, all factors specifically relevant to determining whether a director has a relationship to such company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including, but not limited to: (1) the source of compensation of the director, including any consulting advisory or other compensatory fee paid by such company to the director; and (2) whether the director is affiliated with the company or any of its subsidiaries or affiliates.

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In March 2026, our board of directors undertook a review of the composition of our board of directors and its committees and the independence of each director. Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our board of directors has determined that Anthony P. Adamis, M.D., Napoleone Ferrara, M.D., David Hallal, Morana Jovan-Embiricos, Ph.D., and Leone Patterson are “independent” as that term is defined under the applicable rules and regulations of the listing requirements and rules of Nasdaq, including, in the case of the members of our audit committee, the independence criteria set forth in Rule 10A-3 under the Exchange Act, and in the case of David Hallal, a member of our compensation committee, the independence criteria set forth in Rule 10C-1 under the Exchange Act. In making such determination, our board of directors considered the relationships that each such non-employee director has with our company and all other facts and circumstances that our board of directors deemed relevant in determining his or her independence, including the beneficial ownership of our capital stock by each non-employee director.

Controlled Company

A listed company of which more than 50% of the voting power is held by an individual, group or another company is a “controlled company” within the meaning of the corporate governance standards of Nasdaq and may elect not to comply with certain corporate governance standards, including the requirements that (1) a majority of the board of directors consist of independent directors; (2) director nominations be made, or recommended to the full board of directors, by independent directors or by a nominating committee that is composed entirely of independent directors that has adopted a written charter addressing the nominations process; and (3) the compensation committee be composed entirely of independent directors. We are a “controlled company” within the meaning of the corporate governance standards of Nasdaq because Samsara LP beneficially owns a majority of the voting power of all outstanding shares of our common stock. We have elected to comply with certain exemptions available to a “controlled company”, including that our compensation committee does not consist entirely of independent directors and that director nominations are recommended to the full board of directors by a nominating committee that is not composed entirely of independent directors.

Board Leadership Structure

Currently, the roles of Chair of our board of directors and Chief Executive Officer are separated. Mr. Hallal is the Chair of our board of directors and Mr. Oxtoby is our Chief Executive Officer. We believe that separating these positions allows our Chief Executive Officer to focus on our day-to-day business, while allowing our Chair of the board of directors to lead the board of directors in providing advice to, and independent oversight of, our management. While our amended and restated by-laws and corporate governance guidelines do not require that the Chair of our board of directors and Chief Executive Officer be separate, our board of directors believes that having separate positions is the appropriate leadership structure for us at this time and demonstrates our commitment to good corporate governance.

Board’s Role in Risk Oversight

One of the key functions of our board of directors is informed oversight of our risk management process. Risk is inherent with every business and how well a business manages risk can ultimately determine its success. We face a number of risks, including those described under the caption “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2025 filed with the SEC on March 17, 2026.

Our board of directors is actively involved in the oversight of risks that could affect us. This oversight is conducted primarily by our full board of directors, which has responsibility for general oversight of risks. Our board of directors oversees our risk management processes directly and through its committees, which address risks inherent in their respective areas of oversight. Our risk management processes are intended to identify, manage and control risks so that they are appropriate considering our scope, operations and business objectives. Our management is responsible for risk management on a day-to-day basis and our board of directors and its

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committees oversee the risk management activities of management. Our board of directors encourages management to promote a culture that incorporates risk management into our corporate strategy and day-to-day business operations. Management discusses strategic and operational risks at regular management meetings and conducts specific strategic planning and review sessions during the year that include a focused discussion and analysis of the risks facing us.

Our board of directors satisfies its risk oversight responsibility through full reports by each committee Chair regarding the committee’s considerations and actions, as well as through regular reports directly from officers responsible for oversight of particular risks within our company. This enables our board of directors to coordinate risk oversight, particularly with respect to interrelated or cumulative risks that may involve multiple areas for which more than one committee may have responsibility.

Our audit committee oversees risk management activities relating to financial, legal and compliance risks. This includes a formal annual risk assessment process as well as an ongoing assessment of the relevant risks based upon changes in the industry and overall business environment. Our compensation committee oversees risk management activities relating to our compensation policies and practices and management succession planning. Our nominating and corporate governance committee oversees risk management activities relating to board composition. In addition, members of our senior management team attend our regular board meetings and are available to address any questions or concerns raised by the board on risk management and any other matters. We also engage outside advisors and experts to assist in the risk assessment process, to provide information to inform decision making and to identify trends and changes in the industry and overall business environment. Our board of directors believes that full and open communication between management and the board of directors is essential for effective risk management and oversight.

Director Nomination Process

Director Qualifications

Our nominating and corporate governance committee recommends to our board of directors specific, minimum qualifications that our nominating and corporate governance committee believes must be met by a committee-recommended nominee for a position on our board of directors, including the nominee’s skills, breadth of experience or other background characteristics and independence. Our nominating and corporate governance committee also recommends to our board of directors specific qualities or skills that our nominating and corporate governance committee believes are necessary for one or more of our directors to possess.

The nominating and corporate governance committee believes that our board of directors, taken as a whole, should embody a range of attributes. When considering nominees for the purpose of filling any vacancy on the board of directors, the nominating and corporate governance committee includes, and has any search firm that it engages include, one or more qualified candidates who reflect a range of backgrounds.

The nominating and corporate governance committee’s goal is to assemble a board of directors that brings to our company a variety of perspectives and skills derived from high quality business and professional experience. Moreover, the nominating and corporate governance committee believes that the background and qualifications of the board of directors, considered as a group, should provide a significant breadth of experience, knowledge and abilities that will assist the board of directors in fulfilling its responsibilities. Our directors’ qualification criteria are reviewed periodically by the nominating and corporate governance committee.

Identification and Evaluation of Nominees for Directors

The nominating and corporate governance committee is responsible for identifying individuals qualified to serve as directors and recommending the persons to be nominated for election as directors, except where we are legally required by contract, law or otherwise to provide third parties with the right to nominate director candidates. The process followed by the nominating and corporate governance committee to identify and evaluate director

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candidates includes consultations with management and members of the board of directors; the use of third party search firms or other advisors; recommendations submitted by stockholders; or such other methods as the nominating and corporate governance committee deems to be helpful to identify candidates. Once director candidates have been identified, our nominating and corporate governance committee confirms that the candidates meet any minimum qualifications for director nominees established by the nominating and corporate governance committee, as discussed in more detail above. The nominating and corporate governance committee may gather information about candidates through interviews, detailed questionnaires, background checks or any other means that the nominating and corporate governance committee deems to be appropriate in the evaluation process. The nominating and corporate governance committee then meets as a group to discuss and evaluate the qualities and skills of each candidate, both on an individual basis and taking into account the overall composition and needs of our board of directors. Based on the results of the evaluation process, the nominating and corporate governance committee makes its recommendations to our board of directors.

As discussed above, the nominating and corporate governance committee will consider director candidates recommended by stockholders. The nominating and corporate governance committee does not intend to alter the manner in which it evaluates candidates, including any minimum qualifications established by the nominating and corporate governance committee, based on whether or not the candidate was recommended by a stockholder. Stockholders who wish to recommend individuals for consideration by the nominating and corporate governance committee to become nominees for election to our board of directors may do so by delivering written notice to our Secretary at 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922 not later than the close of business on the 90th day, nor earlier than the close of business on the 120th day, prior to the one-year anniversary of the preceding year’s annual meeting. Submissions must include all information relating to such person that is required to be disclosed in solicitations of proxies for election of directors in an election contest, or is otherwise required, in each case pursuant to Regulation 14A under the Exchange Act (including such person’s written consent to being named in the proxy statement as a nominee and to serve as a director if elected). If the board of directors determines to nominate a stockholder-recommended candidate and recommends his or her election, then his or her name will be included in our proxy card for the next annual meeting. Stockholders also have the right under our amended and restated by-laws and the universal proxy rules to directly nominate director candidates, without any action or recommendation on the part of the nominating and corporate governance committee or our board of directors, by following the procedures set forth under “Stockholder Proposals for our 2027 Annual Meeting.”

Communications with Our Board of Directors

Our board of directors will give appropriate attention to written communications that are submitted by stockholders, and will respond if and as appropriate. Any interested party with concerns about our company may report such concerns to the board of directors, or the Chair of our board of directors, or otherwise the Chair of the nominating and corporate governance committee, by submitting a written communication to the attention of such director at the following address: Kalaris Therapeutics, Inc., 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922.

Communications are forwarded to all directors if they relate to important substantive matters and include suggestions or comments that the Chair of our board of directors or the Chair of the nominating and corporate governance committee, as applicable, considers to be important for the directors to know. In general, communications relating to corporate governance and corporate strategy are more likely to be forwarded than communications relating to ordinary business affairs, personal grievances and matters as to which we receive repetitive or duplicative communications.

A copy of any such written communication may also be forwarded to our legal counsel and a copy of such communication may be retained for a reasonable period of time. The director may discuss the matter with our legal counsel, with independent advisors, with non-management directors, or with our management, or may take other action or no action as the director determines in good faith, using reasonable judgment, and discretion.

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The audit committee oversees the procedures for the receipt, retention, and treatment of complaints received by us regarding accounting, internal accounting controls or auditing matters, and the confidential, anonymous submission of concerns regarding questionable accounting or auditing matters. We have also established a toll-free telephone number for the reporting of such activity, which is (844) 964-1670.

Board Meetings and Attendance

Our board of directors met six times during the year ended December 31, 2025, including telephonic meetings. During the year, each of our directors then in office attended 75% or more of the aggregate number of meetings of the board of directors and the committees on which he or she served.

Director Attendance at Annual Meeting

We encourage our board of directors to attend our annual meetings of stockholders. All of our directors then in office, other than Napoleone Ferrara and Leone Patterson, attended our annual meeting of stockholders in 2025 virtually.

Committees of Our Board of Directors

Our board of directors has established an audit committee, a compensation committee and a nominating and corporate governance committee, each of which operate under a charter approved by our board of directors. Because we are a “controlled company” under the corporate governance standards of Nasdaq, we are not required to have a compensation committee composed of independent directors and we are not required to have director nominations be made, or recommended to the full board of directors, by independent directors or by a nominating committee that is composed entirely of independent directors that has adopted a written charter addressing the nominations process. Each committee’s charter is posted on “Investors & Press—Corporate Governance” section of our website, www.kalaristx.com.

Audit Committee

Our audit committee held three meetings during the year ended December 31, 2025. Prior to the Merger, the members of the AlloVir audit committee were Jeffrey Bornstein, Morana Jovan-Embiricos, Ph.D., and Shawn Tomasella, and Mr. Bornstein served as Chair of the AlloVir audit committee. The members of our audit committee are currently Anthony P. Adamis, M.D., Morana Jovan-Embiricos, Ph.D., and Leone Patterson, and Ms. Patterson serves as the Chair of the audit committee. David Hallal served as the Chair of our audit committee from the closing of the Merger until April 2025. Our board of directors has determined that Ms. Patterson is an “audit committee financial expert” as defined by applicable SEC rules and that each of the members of our audit committee possesses the financial sophistication required for audit committee members under Nasdaq rules. We believe that the composition of our audit committee meets the requirements for independence under current Nasdaq and SEC rules and regulations. Our audit committee’s responsibilities include:

| • |  | appointing, retaining and terminating, and determining the compensation of, and evaluating the independence of our independent registered public accounting firm;

| • |  | pre-approving all auditing services and the terms of those services and non-audit services to be provided by our independent registered public accounting firm;

| • |  | reviewing the overall audit plan with our independent registered public accounting firm and the members of management responsible for preparing our financial statements;

| • |  | reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures as well as critical accounting policies and practices used by our company;

| • |  | reviewing and reassessing the adequacy of our internal control over financial reporting;

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| • |  | establishing procedures for the receipt, retention and treatment of accounting-related complaints and concerns;

| • |  | recommending based upon the audit committee’s review and discussions with management and our independent registered public accounting firm whether our audited financial statements shall be included in our Annual Report on Form 10-K;

| • |  | overseeing the integrity of our financial statements and our compliance with legal and regulatory requirements as they relate to our financial statements and accounting matters;

| • |  | preparing the audit committee report required by SEC rules to be included in our annual proxy statement;

| • |  | reviewing all related person transactions for potential conflict of interest situations and approving all such transactions; and

| • |  | discussing our quarterly earnings press releases.

Compensation Committee

Our compensation committee held two meetings during the year ended December 31, 2025. Prior to the Merger, the members of the AlloVir compensation committee were Jeffrey Bornstein, Derek Adams, Ph.D., and Morana Jovan-Embiricos, Ph.D., and Dr. Jovan-Embiricos served as Chair of the AlloVir compensation committee. The members of our compensation committee are currently Michael Dybbs, Ph.D., and David Hallal, and Dr. Dybbs serves as the Chair of the compensation committee. Samir Patel, M.D. served as a member of our compensation committee from the closing of the Merger until May 2025. Our compensation committee’s responsibilities include:

| • |  | annually reviewing and recommending to our board of directors the corporate goals and objectives relevant to the compensation of our Chief Executive Officer;

| • |  | evaluating the performance of our Chief Executive Officer in light of such corporate goals and objectives and based on such evaluation recommending to our board of directors for determination the equity and non-equity compensation of our Chief Executive Officer;

| • |  | determining and approving the equity and non-equity compensation of our other executive officers;

| • |  | overseeing and administering our overall compensation structure, policies and programs;

| • |  | evaluating and assessing potential and current compensation advisors in accordance with the independence standards identified in the applicable Nasdaq rules;

| • |  | retaining and approving the compensation of any compensation advisors;

| • |  | reviewing and making recommendations to our board of directors about our policies and procedures for the grant of equity-based awards;

| • |  | reviewing and making recommendations to our board of directors about director compensation;

| • |  | preparing the compensation committee report required by SEC rules, if and when required, to be included in our proxy statement; and

| • |  | reviewing and approving the retention, termination or compensation of any consulting firm or outside advisor to assist in the evaluation of compensation matters.

Nominating and Corporate Governance Committee

Our nominating and corporate governance committee did not hold a meeting during the year ended December 31, 2025. Prior to the Merger, the members of the AlloVir nominating and corporate governance committee were Malcom Brenner, M.D., Ph.D., Derek Adams, Ph.D., and Shawn Tomasello, and Dr. Brenner served as Chair of

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the AlloVir nominating and corporate governance committee. The members of our nominating and corporate governance committee are currently Srinivas Akkaraju, M.D., Ph.D., Napoleone Ferrara, M.D., and David Hallal, and Dr. Akkaraju serves as the Chair of the nominating and corporate governance committee. Our nominating and corporate governance committee’s responsibilities include:

| • |  | developing and recommending to our board of directors criteria for board and committee membership;

| • |  | establishing a policy with regard to the consideration of board of director candidates, including establishing procedures to be followed by stockholders in submitting recommendations for director candidates;

| • |  | identifying and evaluating nominees for our board of directors;

| • |  | recommending to our board of directors the persons to be nominated for election as directors and to each of the board’s committees;

| • |  | developing and recommending to our board of directors a set of corporate governance guidelines; and

| • |  | overseeing the periodic evaluation of our board of directors and its committees.

Code of Business Conduct and Ethics

We have adopted a written code of business conduct and ethics that applies to all directors, officers and employees, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. This code is available on the “Investors & Press - Corporate Governance” section of our website, www.kalaristx.com. If we make any substantive amendments to, or grant any waivers from, the code of business conduct and ethics for any officer or director, we will disclose the nature of such amendment or waiver on our website or in a Current Report on Form 8-K.

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Insider Trading Policy
We have adopted an insider trading policy which governs transactions in our securities by our directors, officers, employees and consultants. We believe our insider trading policy is reasonably designed to promote compliance with insider trading laws, rules and regulations, and Nasdaq listing standards. A copy of our insider trading policy is filed as Exhibit 19.1 to our Annual Report on Form
10-K
for the fiscal year ended December 31, 2025.
Policy on Trading, Pledging and Hedging of Company Stock
Certain transactions in our securities (such as purchases and sales of publicly traded put and call options, and short sales) create a heightened compliance risk or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the risk that a sale may occur at a time when an officer or director is aware of material,
non-public
information or otherwise is not permitted to trade in company securities. Our insider trading policy expressly prohibits derivative transactions of our stock by our executive officers, directors, employees, consultants and designated contractors. Our insider trading policy expressly prohibits purchases of any derivative securities that provide the economic equivalent of ownership.
Incentive Compensation Recoupment Policy
In accordance with the requirements of the SEC and Nasdaq listing rules, our compensation committee has adopted a compensation recovery policy, or the Clawback Policy, adopted as of October 26, 2023. The Clawback Policy provides that in the event we are required to prepare a restatement of financial statements due to material noncompliance with any financial reporting requirement under securities laws, we will seek to recover any incentive-based compensation that was based upon the attainment of a financial reporting measure and that was received by any current or former executive officer during the three-year period preceding the date that the restatement was required if such compensation exceeds the amount that the executive officers would have received based on the restated financial statements.
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Report of the Audit Committee of the Board of Directors

The audit committee oversees the Company’s financial reporting process on behalf of the board of directors. We have reviewed the Company’s audited consolidated financial statements for the year ended December 31, 2025 and discussed them with Company management and Deloitte & Touche LLP, the Company’s independent registered public accounting firm.

We have received from, and discussed with, Deloitte & Touche LLP, which is responsible for expressing an opinion on the conformity of the Company’s audited consolidated financial statements with accounting principles generally accepted in the United States such matters as are required to be discussed with the audit committee under generally accepted auditing standards, including the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board, or the PCAOB, and the SEC. In addition, we have received from Deloitte & Touche LLP the written disclosures and the letter required by applicable requirements of the PCAOB regarding its communications with us concerning independence and have discussed with Deloitte & Touche LLP its independence from management and the Company.

Based on the review and discussions referred to above, we recommended to the board of directors that the audited consolidated financial statements be included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025.

This report of the audit committee is not “soliciting material,” shall not be deemed “filed” with the SEC and shall not be incorporated by reference by any general statement incorporating by reference this proxy statement into any filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing, except to the extent that we specifically incorporate this information by reference, and shall not otherwise be deemed filed under such acts.

The foregoing report has been furnished by the audit committee.

Respectfully submitted,

The Audit Committee of the Board of Directors

Leone Patterson, Chair

Anthony P. Adamis, M.D.

Morana Jovan-Embiricos, Ph.D.

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PROPOSAL NO. 2

ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS

We are providing our stockholders the opportunity to vote to approve, on an advisory, non-binding basis, the compensation of the executive officers named in the Summary Compensation Table under “Executive Compensation,” or our named executive officers, as disclosed in this proxy statement in accordance with Section 14A of the Exchange Act. This proposal, which is commonly referred to as “say-on-pay,” is required by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, or the Dodd-Frank Act, which added Section 14A to the Exchange Act. Section 14A of the Exchange Act also requires that stockholders have the opportunity to cast an advisory vote with respect to whether future advisory votes on the compensation of our named executive officers will be held every one, two or three years, which is the subject of the non-binding advisory vote in Proposal No. 3.

Our executive compensation programs are designed to attract, motivate, and retain our executive officers, who are critical to our success. Under these programs, our named executive officers are rewarded for the achievement of our near-term and longer-term financial and strategic goals and for driving corporate performance and stability. The programs contain elements of cash and equity-based compensation and are designed to align the interests of our executives with those of our stockholders.

The section of this proxy statement titled “Executive and Director Compensation” beginning on page 28, describes in detail our executive compensation program and the decisions made by our compensation committee and our board of directors for the year ended December 31, 2025. Our executive compensation program is designed to reward value creation for stockholders and progress towards achieving our mission and promote company performance. At the same time, we believe our program does not encourage excessive risk-taking by management. While we do not have a formal or informal policy for allocating between long-term and short-term compensation, between cash and non-cash compensation or among different forms of non-cash compensation, we generally strive to provide our named executive officers with a mix of short-term and long-term performance-based incentives to encourage strong performance, and our board of directors believes that this link between compensation and the achievement of our short- and long-term business goals has helped drive our performance over time.

Our board of directors is asking stockholders to approve, on an advisory, non-binding basis, the following resolution:

RESOLVED, that the compensation paid to the company’s named executive officers, as disclosed pursuant to the compensation disclosure rules of the Securities and Exchange Commission, including the compensation tables and any related material disclosed in this proxy statement, is hereby approved.

As an advisory vote, this proposal is not binding. Neither the outcome of this advisory vote nor the advisory vote included in Proposal No. 3 will overrule any decision by the Company or our board of directors (or any committee thereof), create or imply any change to the fiduciary duties of the Company or our board of directors (or any committee thereof), or create or imply any additional fiduciary duties for the Company or our board of directors (or any committee thereof). However, our compensation committee and our board of directors value the opinions expressed by our stockholders in their vote on this proposal and intend to consider carefully the outcome of the vote when making future compensation decisions for our named executive officers.

Recommendation of the Board of Directors

OUR BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE, ON AN ADVISORY BASIS, TO APPROVE THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS BY VOTING “FOR” THIS PROPOSAL.

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PROPOSAL NO. 3

ADVISORY VOTE ON THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE

COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS

In Proposal No. 2, we are providing our stockholders the opportunity to vote to approve, on an advisory, non-binding basis, the compensation of our named executive officers. In this Proposal No. 3, we are asking our stockholders to cast a non-binding advisory vote regarding the frequency of future advisory votes on the compensation of our named executive officers. Stockholders may vote for a frequency of every “ONE YEAR”, “TWO YEARS”, or “THREE YEARS” or may abstain.

Our board of directors intends to consider carefully the outcome of this vote in making a determination about the frequency of future advisory votes on the compensation of our named executive officers. However, because this vote is advisory and non-binding, our board of directors may decide that it is in the best interests of our and our stockholders to hold the advisory vote on the compensation of our named executive officers more or less frequently, but no less frequently than once every three years, as required by the Dodd-Frank Act. In the future, we will propose an advisory vote on the frequency of the advisory vote on the compensation of our named executive officers at least once every six calendar years as required by the Dodd-Frank Act.

After careful consideration, our board of directors believes that an advisory vote on the compensation of our named executive officers should be held every “ONE YEAR”. Therefore, our board of directors recommends that you vote for a frequency of every “ONE YEAR” for future advisory votes on the compensation of our named executive officers.

Our board of directors believes that an annual advisory vote on the compensation of our named executive officers will facilitate more direct stockholder input about executive compensation. An annual advisory vote on the compensation of named executive officers is consistent with our policy of reviewing our executive compensation program annually, as well as seeking frequent input from our stockholders on corporate governance and executive compensation matters. We believe an annual vote would be the best governance practice for the Company at this time.

Recommendation of the Board of Directors

OUR BOARD OF DIRECTORS BELIEVES THAT HOLDING THE ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS EVERY YEAR IS IN THE BEST INTERESTS OF THE COMPANY AND ITS STOCKHOLDERS AND RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR A FREQUENCY OF EVERY “ONE YEAR”.

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PROPOSAL NO. 4

RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The audit committee has selected Deloitte and Touche LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2026, and our board of directors has directed that management submit the selection of the independent registered public accounting firm for ratification by the stockholders at the Annual Meeting. Deloitte and Touche LLP served as the registered public accounting firm of AlloVir since 2016, and Deloitte and Touche LLP served as the registered public accounting firm of Legacy Kalaris since 2024. Representatives of Deloitte and Touche LLP are expected to be present online at the Annual Meeting, will have an opportunity to make a statement if they so desire, and will be available to respond to appropriate questions.

Stockholder ratification of the selection of Deloitte and Touche LLP as our independent registered public accounting firm is not required by Delaware law, our restated certificate of incorporation or our amended and restated by-laws. However, the board of directors is submitting the audit committee’s selection of Deloitte and Touche LLP to the stockholders for ratification as a matter of good corporate practice. If the stockholders fail to ratify the selection, the audit committee will reconsider whether to retain that firm. Even if the selection is ratified, the audit committee in its discretion may direct the selection of a different independent registered public accounting firm at any time during the year if the audit committee determines that such a change would be in the best interests of the Company and our stockholders.

Independent Registered Public Accountants, Fees and Other Matters

Deloitte and Touche LLP was our independent registered public accounting firm for the year ended December 31, 2025 and the independent registered public accounting firm for AlloVir for the year ended December 31, 2024. The following table summarizes the fees of Deloitte and Touche LLP billed to AlloVir, prior to the closing of the Merger, and to us, following the closing of the Merger, for the last two fiscal years. All such services and fees were pre-approved by the respective audit committees in accordance with the “Pre-Approval Policies and Procedures” described below.

|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Audit Fees (1) |  |  | $1,130,325 |  |  |  | $1,328,460 |
Audit-related Fees (2) |  |  | 80,000 |  |  |  | — |
Tax Fees (3) |  |  | 116,484 |  |  |  | 204,702 |
All Other Fees |  |  | — |  |  |  | — |
Total |  |  | $1,326,809 |  |  |  | $1,553,162 |

(1) | “Audit Fees” for 2025 consist of fees for the audit of our annual consolidated financial statements, the review of our interim consolidated financial statements and other professional services provided to us in connection with regulatory filings, including those associated with the Merger. “Audit Fees” for 2024 consist of fees for the audit of AlloVir’s annual consolidated financial statements, the review of AlloVir’s interim consolidated financial statements and other professional services provided to AlloVir in connection with regulatory filings.

(2) | “Audit-related fees” consist of system pre-implementation services.

(3) | “Tax Fees” consist of tax compliance and advisory services.

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Deloitte and Touche LLP was Legacy Kalaris’ independent registered public accounting firm prior to the closing of the Merger. The following table summarizes the fees of Deloitte and Touche LLP billed to Legacy Kalaris, prior to the closing of the Merger, for the last two fiscal years.

|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Audit Fees (1) |  |  | $— |  |  |  | $1,031,000 |
Audit-related Fees |  |  | — |  |  |  | — |
Tax Fees |  |  | — |  |  |  | — |
All Other Fees |  |  | — |  |  |  | — |
Total |  |  | $— |  |  |  | $1,031,000 |

(1) | “Audit Fees” consist of fees for the audit of Legacy Kalaris’ annual consolidated financial statements and other professional services provided to Legacy Kalaris in connection with regulatory filings, including those associated with the Merger.

Pre-Approval Policies and Procedures

The charter of our audit committee provides that all audit and non-audit services, other than de minimis non-audit services, to be provided to us by our independent registered public accounting firm must be approved in advance by our audit committee. During our 2025 and 2024 fiscal years, all of the services provided to us and AlloVir by Deloitte and Touche LLP were pre-approved by the predecessor audit committee prior to the closing of the Merger and by our audit committee following the closing of the Merger.

Recommendation of the Board of Directors

OUR BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE TO RATIFY THE SELECTION OF DELOITTE AND TOUCHE LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2026.

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EXECUTIVE OFFICERS

The following table sets forth certain information concerning our executive officers and other key employees, including their ages as of April 1, 2026:

Name |  | Age |  |  | Position
Andrew Oxtoby |  |  | 52 |  |  | President and Chief Executive Officer, Director
Matthew Feinsod, M.D. |  |  | 55 |  |  | Chief Medical Officer

The following is a biographical summary of the experience of our executive officers and other key employees.

Andrew Oxtoby is our President and Chief Executive Officer and a director. Please see “Proposal No. 1-Election of Directors” for biographical information regarding Mr. Oxtoby.

Matthew Feinsod, M.D. has served as our Chief Medical Officer since the closing of the Merger. Dr. Feinsod, a board-certified ophthalmologist, previously served as the Chief Medical Officer of Legacy Kalaris since December 2024. Prior to joining Legacy Kalaris, Dr. Feinsod served as executive vice president of global strategy and development of Applied Genetic Technologies Corp., a clinical-stage biotechnology company, which was acquired by Syncona Limited in December 2022, from August 2019 to May 2022, and as interim chief medical officer of AGTC, from September 2017 to August 2019. Previously, Dr. Feinsod co-founded and led Imagen Biotech, Inc., or Imagen, a venture-backed company dedicated to developing ophthalmology treatments for sight-threatening diseases, from 2011 to 2013. Prior to Imagen, Dr. Feinsod served in various roles, including senior vice president of strategy and product development at Eyetech Pharmaceuticals, Inc. from 2003 to 2007. Dr. Feinsod served as a medical officer in the ophthalmology division of the FDA from 2002 to 2003. He holds a B.S. from the Wharton School of Business at the University of Pennsylvania and an M.D. from the George Washington University School of Medicine.

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EXECUTIVE AND DIRECTOR COMPENSATION

Executive Compensation

At the effective time of the Merger, the management of AlloVir was replaced with the management of Legacy Kalaris. The following discussion relates to the compensation of Andrew Oxtoby, our President and Chief Executive Officer; Matthew Feinsod, our Chief Medical Officer; Matthew Gall, our former Chief Financial Officer; Vikas Sinha, AlloVir’s former Chief Executive Officer, President and Chief Financial Officer; and Brett Hagen, our current Chief Accounting Officer and AlloVir’s former Chief Accounting Officer. Mr. Oxtoby, Mr. Gall, Dr. Feinsod, Mr. Sinha and Mr. Hagen are collectively referred to in this proxy statement as our named executive officers.

Summary Compensation Table

The following table sets forth information regarding compensation awarded to, earned by or paid to each of our named executive officers during the periods indicated.

Name and Principal Position |  | Year |  |  | Salary ($) |  |  | Bonus ($) |  |  | Option Awards ($)(1) |  |  | Non-Equity Incentive Compensation ($)(2) |  |  | All Other Compensation ($) |  |  | Total ($) |
Andrew Oxtoby(3) |  |  | 2025 |  |  |  | 537,733 |  |  |  | — |  |  |  | 1,687,076 |  |  |  | 344,306 |  |  |  | — |  |  |  | 2,569,115 |
President and Chief Executive Officer |  |  | 2024 |  |  |  | 394,160 | (4) |  |  | — |  |  |  | 1,388,585 |  |  |  | 176,856 | (4) |  |  | 5,552 |  |  |  | 1,965,153 |
Matthew Feinsod (5) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Chief Medical Officer |  |  | 2025 |  |  |  | 457,732 |  |  |  | — |  |  |  | 1,008,403 |  |  |  | 207,636 |  |  |  | — |  |  |  | 1,673,771 |
Matthew Gall (6) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Former Chief Financial Officer |  |  | 2025 |  |  |  | 80,833 | (7) |  |  | — |  |  |  | 949,279 |  |  |  | 34,495 | (7) |  |  | — |  |  |  | 1,064,607 |
Vikas Sinha (8) |  |  | 2025 |  |  |  | 81,106 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,019,848 | (9) |  |  | 1,100,954 |
AlloVir’s Former Chief Executive Officer, President and Chief Financial Officer |  |  | 2024 |  |  |  | 375,448 |  |  |  | — |  |  |  | — |  |  |  | 168,952 |  |  |  | — |  |  |  | 544,400 |
Brett Hagen |  |  | 2025 |  |  |  | 397,301 |  |  |  | 67,814 | (10) |  |  | 295,417 |  |  |  | 121,512 |  |  |  | 557,130 | (11) |  |  | 1,439,174 |
Chief Accounting Officer and AlloVir’s former Chief Accounting Officer |  |  | 2024 |  |  |  | 385,320 |  |  |  | 397,191 | (12) |  |  | — |  |  |  | — |  |  |  | 13,800 | (13) |  |  | 796,311 |

(1) | The amounts reported represent the aggregate grant date fair value of the stock options in the applicable fiscal year, calculated in accordance with Financial Accounting Standards Board, or FASB, Accounting Standards Codification, or ASC, Topic 718. The assumptions used in calculating the grant date fair value of the stock options reported in this column are set forth in Note 13 to our audited financial statements included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025. Immediately prior to the effective time of the Merger, in accordance with the terms of the Merger Agreement, each unexercised and outstanding AlloVir option with an exercise price per share equal to or greater than $92.00 was cancelled for no consideration. Accordingly, all unexercised and outstanding AlloVir options held by Mr. Sinha were cancelled for no consideration in connection with the closing of the Merger.

(2) | The amounts represent incentive-based cash compensation earned by our named executive officers in the applicable year. See “Narrative Disclosure to Summary Compensation Table - Annual bonus” below for a general description of the criteria that our board of directors used to determine the incentive-based cash compensation.

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(3) | Effective March 4, 2024, Mr. Oxtoby was appointed as President and Chief Executive Officer of Legacy Kalaris.

(4) | The salary reported in the “Salary” column and the annual incentive-based cash compensation reported in the “Non-Equity Incentive Plan Compensation” column, each for 2024, reflect the pro rata portion of Mr. Oxtoby’s annualized salary and annual incentive-based cash compensation that was earned during 2024.

(5) | Dr. Feinsod was not a named executive officer prior to 2025, and therefore compensation information is not provided for 2024.

(6) | Mr. Gall commenced employment as our Chief Financial Officer effective November 3, 2025, and therefore was not a named executive officer for 2024. Mr. Gall resigned as our Chief Financial Officer effective April 14, 2026.

(7) | The salary reported in the “Salary” column and the incentive-based cash compensation reported in the “Non-Equity Incentive Plan Compensation” column, each for 2025, reflect the pro rata portion of Mr. Gall’s annualized salary and annual incentive-based cash compensation that was earned during 2025.

(8) | Effective December 19, 2024, the AlloVir board of directors appointed Mr. Sinha as Chief Executive Officer of AlloVir. Mr. Sinha also served as a member of the AlloVir board of directors prior to the closing of the Merger but did not receive any additional compensation for his service as a director of AlloVir. On March 18, 2025, in accordance with the terms of the Merger Agreement, effective as of the effective time of the Merger, Mr. Sinha resigned as Chief Executive Officer, President and Chief Financial Officer of AlloVir and resigned as a director of the AlloVir board of directors.

(9) | The amount reported represents severance benefits paid to Mr. Sinha pursuant to a separation agreement and release AlloVir entered into with Mr. Sinha in March 2025.

(10) | The amount reported represents retention bonuses paid to Mr. Hagen pursuant to a retention agreement AlloVir entered into with Mr. Hagen in September 2024.

(11) | The amount reported represents severance benefits paid to Mr. Hagen pursuant to an acknowledgement and release AlloVir entered into with Mr. Hagen in March 2025.

(12) | The amount reported represents retention bonuses paid to Mr. Hagen pursuant to retention agreements AlloVir entered into with Mr. Hagen in February 2024 and May 2024.

(13) | The amount reported represents matching contributions made by AlloVir under its 401(k) plan.

Narrative Disclosure to Summary Compensation Table

We review compensation for our executive officers annually. The material terms of the elements of our executive compensation program for 2025 are described below.

Our board of directors, based on recommendations from our compensation committee, sets base salaries and bonus targets, and grants bonuses and equity incentive awards to our executive officers. In recommending base salaries and bonus targets and equity incentive awards, our compensation committee considers compensation for comparable positions in the market, the historical compensation levels of our executives, individual and corporate performance as compared to our expectations and goals, our desire to motivate our employees to achieve short- and long-term results that are in the best interests of our stockholders, and a long-term commitment to Kalaris. In granting incentive-based cash compensation, our board of directors, based on recommendations from our compensation committee, also considers corporate performance.

As part of our annual compensation process, our chief executive officer prepares performance evaluations for the other executive officers and recommends annual salary increases, annual equity incentive awards and level of achievement of corporate goals to the compensation committee. The compensation committee conducts a performance evaluation of our chief executive officer. The compensation committee consults with our board of directors as to the achievement of corporate goals that drive compensation awards.

During its annual compensation review, our compensation committee also consults with external advisors. In fiscal 2025, the compensation committee engaged Aon plc as its independent compensation consultant to provide comparative data on executive compensation practices in our industry and assess our executives’ compensation

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relative to comparable companies. The compensation committee reviewed information regarding the independence and potential conflicts of interest of Aon plc, taking into account, among other things, the factors set forth in the Nasdaq listing standards. Based on such review, the compensation committee concluded that the engagement of Aon plc did not raise any conflict of interest.

Base salary. In 2025, we paid Mr. Oxtoby, Dr. Feinsod and Mr. Gall an annualized base salary of $569,100, $471,900 and $485,000, respectively. Mr. Hagen’s annual base compensation for the year ending December 31, 2025 was $385,320 prior to the closing of the Merger and $400,000 effective as of March 18, 2025. Prior to the closing of the Merger, AlloVir paid Mr. Sinha an annualized base salary of $375,448.

In March 2026, our board of directors increased Mr. Oxtoby’s, Dr. Feinsod’s and Mr. Gall’s annual base salaries to $655,200, $512,600 and $502,000, respectively, effective January 1, 2026.

We use base salaries to recognize the experience, skills, knowledge and responsibilities required of all our employees, including our named executive officers. None of our named executive officers is currently party to an employment agreement or other agreement or arrangement that provides for automatic or scheduled increases in base salary.

Annual bonus. Our board of directors may, in its discretion, award bonuses to our named executive officers from time to time. We typically establish annual bonus targets based on specified corporate goals. For 2025, Mr. Oxtoby and Dr. Feinsod were eligible to receive an annual bonus, and Mr. Gall was eligible to receive a pro-rated annual bonus.

For 2025, the target bonus amounts, expressed as a percentage of total salary earned during 2025, for each of Mr. Oxtoby, Dr. Feinsod, Mr. Gall and Mr. Hagen were as follows: 55%, 40%, 40% and 35%, respectively. With respect to 2025, our board of directors awarded bonuses of $344,306, $207,636, $34,495 (pro-rated) and $121,512 (pro-rated) to Mr. Oxtoby, Dr. Feinsod, Mr. Gall and Mr. Hagen, respectively.

Mr. Oxtoby’s and Dr. Feinsod’s target bonus opportunities for 2026 are 55% and 40%, respectively.

Retention Bonus. On April 11, 2024, the AlloVir compensation committee approved cash retention bonuses payable to certain of AlloVir’s employees and executive officers and recommended that the AlloVir board of directors approve cash retention bonuses payable to certain of AlloVir’s executive officers, subject to their continued employment through the consummation of the Merger. The AlloVir board of directors approved the AlloVir compensation committee’s recommendation on May 31, 2024. Mr. Sinha and Mr. Hagen were eligible to receive a retention bonus equal to $100,000 and $34,000, respectively.

Severance benefits. In accordance with the terms of the Merger Agreement, pursuant to the Sinha Separation Agreement and to the terms of the 2019 Sinha Employment Agreement (each as defined below), AlloVir provided certain benefits to Mr. Sinha, including a lump sum in cash in an amount equal to 24 months of Mr. Sinha’s then-current base salary, and a lump sum payment of the retention bonus of $100,000 described below.

In accordance with the terms of the Merger Agreement, pursuant to the terms of the Hagen Acknowledgment and Release and the terms of the Severance Policy (each as defined below), AlloVir provided certain benefits to Mr. Hagen including a lump sum in cash equal to 12 months of Mr. Hagen’s then-current base salary and annual bonus, and a lump sum payment of retention bonuses of $51,381.17 described below.

Equity incentives. Although we do not have a formal policy with respect to the grant of equity incentive awards to our executive officers, or any formal equity ownership guidelines applicable to them, we believe that equity grants provide our executive officers with a strong link to our long-term performance, create an ownership

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culture and help to align the interests of our executive officers and our stockholders. In addition, we believe that equity grants with a time-based vesting feature promote executive retention because this feature incentivizes our executive officers to remain in our employment during the vesting period. Accordingly, our board of directors periodically reviews the equity incentive compensation of our executive officers, including our named executive officers, and from time to time may grant equity incentive awards to them in the form of stock options under our 2020 Stock Option and Grant Plan, or the 2020 Plan.

We have used stock options to compensate our executive officers in the form of initial grants in connection with the commencement of employment and have granted stock options as annual grants. The options that we have granted to our executive officers are typically subject to time-based vesting, generally over four years following the vesting commencement date. Upon certain terminations of employment in connection with a change of control, vesting is fully accelerated. Prior to the exercise of a stock option, the holder has no rights as a stockholder with respect to the shares subject to such option, including no voting rights and no right to receive dividends or dividend equivalents. We have historically awarded stock options with exercise prices that are equal to the fair market value of our common stock on the date of grant.

In April 2025, we granted options to purchase 287,000, 101,000 and 50,262 shares of our common stock to Mr. Oxtoby, Dr. Feinsod and Mr. Hagen, respectively. Such options vested as to 25% of the shares underlying the option on March 18, 2026 and vest as to 1/48th of the shares underlying the option monthly thereafter, subject to continued service.

We also granted options to purchase 70,551 shares of our common stock to Dr. Feinsod in April 2025, pursuant to the Feinsod Employment Agreement (as defined below), with 25% of the shares underlying the option having vested on December 31, 2025, and 1/48th of the shares vesting monthly thereafter, subject to continued service. Additionally, in November 2025, we granted options to purchase 235,000 shares our common stock to Mr. Gall, pursuant to the Gall Employment Agreement (as defined below), with 25% of the shares underlying the option having vested on November 3, 2026, and vest as to 1/48th of the shares underlying the option monthly thereafter, subject to continued service.

Outstanding Equity Awards at 2025 Fiscal Year-End

The following table sets forth information concerning outstanding equity awards held by our named executive officers as of December 31, 2025.

|  | Option awards |
Name |  | Grant date |  |  | Number of securities underlying unexercised options (#) exercisable |  |  | Number of securities underlying unexercised options (#) unexercisable |  |  | Option exercise price ($) |  |  | Option expiration date |
Andrew Oxtoby |  |  | 5/28/2024 | (1) |  |  | 208,521 |  |  |  | 268,090 | (2) |  |  | $0.85 |  |  |  | 5/27/2034 |
|  |  | 4/10/2025 |  |  |  | — |  |  |  | 287,000 | (3) |  |  | $7.31 |  |  |  | 4/9/2035 |
Matthew Feinsod |  |  | 7/23/2024 | (1) |  |  | 8,064 |  |  |  | 20,160 | (4) |  |  | $0.85 |  |  |  | 7/22/2034 |
|  |  | 4/10/2025 |  |  |  | 17,638 |  |  |  | 52,913 | (5) |  |  | $7.31 |  |  |  | 4/9/2035 |
|  |  | 4/10/2025 |  |  |  | — |  |  |  | 101,000 | (3) |  |  | $7.31 |  |  |  | 4/9/2035 |
Matthew Gall |  |  | 11/3/2025 |  |  |  | — |  |  |  | 235,000 | (6) |  |  | $4.99 |  |  |  | 11/2/2035 |
Vikas Sinha(7) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Brett Hagen(7) |  |  | 4/10/2025 |  |  |  | — |  |  |  | 50,262 | (3) |  |  | $7.31 |  |  |  | 4/9/2035 |

(1) | This option was assumed in connection with the closing of the Merger. Pursuant to the terms of the Merger Agreement, as of the effective time of the Merger, each outstanding option to purchase shares of Legacy Kalaris common stock, whether or not vested, was converted into an option to acquire shares of our

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| common stock, with necessary adjustments to the number of shares and exercise price to reflect the Exchange Ratio equal to 0.2016 per share, on the same terms and conditions as were applicable immediately prior to the effective time of the Merger.

(2) | This option vests over four years, with 25% of the shares having vested on March 4, 2024, and the remainder vesting in equal monthly installments thereafter, subject to continuous service.

(3) | This option vests over four years, with 25% of the shares having vested on March 18, 2026, and the remainder vesting in equal monthly installments thereafter, subject to continuous service.

(4) | This option vests over four years, with 2.0833% of the shares underlying the option vested on July 17, 2024 and 2.0833% of the shares vesting monthly thereafter.

(5) | This option vests over four years, with 25% of the shares having vested on December 31, 2025, and the remainder vesting in equal monthly installments thereafter, subject to continuous service.

(6) | This option vests over four years, with 25% of the shares vesting on November 3, 2026, and the remainder vesting in equal monthly installments thereafter, subject to continuous service.

(7) | Immediately prior to the effective time of the Merger, in accordance with the terms of the Merger Agreement, each unexercised and outstanding AlloVir option with an exercise price per share equal to or greater than $92.00 was cancelled for no consideration. Accordingly, all unexercised and outstanding AlloVir options held by Mr. Sinha and Mr. Hagen were cancelled for no consideration in connection with the closing of the Merger. In connection with Mr. Sinha’s resignation from AlloVir at the effective time of the Merger, any unvested AlloVir RSUs held by Mr. Sinha were fully accelerated, pursuant to the Sinha Separation Agreement and the 2019 Sinha Employment Agreement, respectively. Additionally, in connection with the closing of the Merger, any unvested AlloVir RSUs held by Mr. Hagen were fully accelerated, pursuant to the Hagen Acknowledgment and Release and the Severance Policy.

Employment Agreements and Other Arrangements

Andrew Oxtoby

On April 10, 2025, we entered into an employment agreement, or the Oxtoby Employment Agreement, with Andrew Oxtoby in connection with his continued employment as our President and Chief Executive Officer. The Oxtoby Employment Agreement supersedes all pre-existing agreements and understandings that Mr. Oxtoby may have entered into concerning his employment relationship with us and our subsidiaries.

Mr. Oxtoby’s base salary is subject to annual review and adjustment by our compensation committee. Mr. Oxtoby’s annual base salary was $655,200, effective January 1, 2026. In addition, Mr. Oxtoby is eligible to receive a discretionary bonus in a target amount of 55% of his annual base salary, as determined by our board of directors in its sole discretion. Mr. Oxtoby is also eligible to participate in our employee benefit plans, subject to the terms of those plans.

Under the Oxtoby Employment Agreement, if more than three months prior to or more than 12 months following a “change in control” (as defined in the Oxtoby Employment Agreement) of the Company, Mr. Oxtoby’s employment is terminated us without “cause” or by him for “good reason” (each as defined in the Oxtoby Employment Agreement), Mr. Oxtoby is entitled to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the “restrictive covenant agreements” (as defined in the Oxtoby Employment Agreement) and any similar agreements with us, (i) continued payment of his base salary for a period of 12 months following his termination date, and (ii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to the COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to 12 months.

Furthermore, if, within three months prior to or within 12 months following a change in control of the company, Mr. Oxtoby’s employment is terminated by us without cause or by him for good reason, Mr. Oxtoby is entitled

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to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the restrictive covenant agreements and any similar agreements with us, (i) continued payment of his base salary for a period of 18 months following his termination date, (ii) a lump-sum payment equal to 150% of the Oxtoby Target Bonus for the year in which his termination occurs or, if higher, the Oxtoby Target Bonus immediately prior to the change in control, (iii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to 18 months, and (iv) the acceleration of his then-unvested equity awards that vest based solely on the passage of time, such that all such then-unvested equity awards immediately vest and become fully exercisable or non-forfeitable as of his termination date.

Matthew Feinsod, M.D.

On May 12, 2025, we entered into an employment agreement, or the Feinsod Employment Agreement, with Matthew Feinsod, M.D., in connection with his continued employment as our Chief Medical Officer. The Feinsod Employment Agreement supersedes all pre-existing agreements and understandings that Dr. Feinsod may have entered into concerning his employment relationship with us and our subsidiaries.

Dr. Feinsod’s base salary is subject to annual review and adjustment by our compensation committee. Dr. Feinsod’s annual base salary was $512,600, effective January 1, 2026. In addition, Dr. Feinsod is eligible to receive a discretionary bonus in a target amount of 40% of his annual base salary, as determined by our board of directors in its sole discretion. Dr. Feinsod is also eligible to participate in our employee benefits plans, subject to the terms of those plans.

Under the Feinsod Employment Agreement, if more than three months prior to or more than 12 months following a “change in control” (as defined in the Feinsod Employment Agreement) of the company, Dr. Feinsod’s employment is terminated by us without “cause” or by him for “good reason” (each as defined in the Feinsod Employment Agreement), Dr. Feinsod is entitled to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the “restrictive covenant agreements” (as defined in the Feinsod Employment Agreement) and any similar agreements with us, (i) continued payment of his base salary for a period of nine months following his termination date, and (ii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to nine months.

Furthermore, if, within three months prior to or within 12 months following a change in control of the company, Dr. Feinsod’s employment is terminated by us without cause or by him for good reason, Dr. Feinsod is entitled to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the restrictive covenant agreements and any similar agreements with us, (i) continued payment of his base salary for a period of 12 months following his termination date, (ii) a lump-sum payment equal to 100% of the Feinsod Target Bonus for the year in which his termination occurs or, if higher, the Feinsod Target Bonus immediately prior to the change in control, (iii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to 12 months, and (iv) the acceleration of his then-unvested equity awards that vest based solely on the passage of time, such that all such then-unvested equity awards immediately vest and become fully exercisable or non-forfeitable as of his termination date.

Matthew Gall

On November 1, 2025, we entered into an employment agreement, or the Gall Employment Agreement, with Matthew Gall, in connection with his appointment as our Chief Financial Officer.

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Mr. Gall’s base salary was subject to annual review and adjustment by our compensation committee. Mr. Gall’s annual base salary was $502,000, effective January 1, 2026. In addition, Mr. Gall was eligible to receive a discretionary bonus in a target amount of 40% of his annual base salary, as determined by our board of directors in its sole discretion. Mr. Gall was also eligible to participate in our employee benefits plans, subject to the terms of those plans. On April 8, 2026, Mr. Gall notified us of his intent to resign, effective April 14, 2026.

Vikas Sinha

Employment Agreement. On October 2, 2019, AlloVir and Vikas Sinha entered into an Amended and Restated Employment Agreement, or the 2019 Sinha Employment Agreement, which provided for an initial annual base salary of $400,000 and an annual target bonus opportunity of 40% of Mr. Sinha’s then current base salary. The 2019 Sinha Employment Agreement additionally provided that, notwithstanding the terms of any equity agreements or plans pursuant to which Mr. Sinha was granted equity in AlloVir, all unvested equity would have vested upon the close of a Sale Event (as defined in the 2020 Plan). In connection with the 2019 Sinha Employment Agreement, AlloVir and Mr. Sinha also entered into a restrictive covenants agreement, or the Restricted Covenants Agreement, and in consideration for which Mr. Sinha received a one-time cash payment of $5,000.

Pursuant to the 2019 Sinha Employment Agreement, if Mr. Sinha’s employment (i) was terminated without Cause (as defined in the 2019 Sinha Employment Agreement) or (ii) if he terminated his employment for Good Reason (as defined in the 2019 Sinha Employment Agreement), then Mr. Sinha would have been entitled to (i) a lump sum payment equal to 24 months, or the Sinha Severance Period, of his then current base salary, (ii) a lump sum payment equal to his target annual bonus (together with the lump sum payment described in (i) above, the Sinha Severance Amount), provided that notwithstanding the foregoing, in the event Mr. Sinha was entitled to any payments pursuant to the Restrictive Covenants Agreement, the Sinha Severance Amount would have been reduced by the amount Mr. Sinha was paid pursuant to the Restrictive Covenants Agreement, (iii) provided Mr. Sinha timely elected to continue health coverage under COBRA, reimbursement for any monthly COBRA premium payments made by Mr. Sinha, until the earlier of (a) the expiration of the Sinha Severance Period, (b) Mr. Sinha’s eligibility for group medical plan benefits under any other employer’s group medical plan, or (c) the cessation of Mr. Sinha’s continuation rights under COBRA, and (iv) the immediate vesting of any non-vested equity-related instruments.

Payment by AlloVir of the foregoing severance amounts was contingent upon Mr. Sinha executing a separation and release agreement in a form and manner satisfactory to AlloVir, which would have included, without limitation, (i) a general release of claims against AlloVir and all related persons and entities, a reaffirmation of all of Mr. Sinha’s Continuing Obligations (as defined in the 2019 Sinha Employment Agreement), and, in the sole discretion of AlloVir, a one-year post-employment non-competition restriction in a form substantially similar to the Non-Competition Restriction (as defined in the Restrictive Covenants Agreement) and (ii) such separation and release becoming irrevocable within 60 days following Mr. Sinha’s termination.

Pursuant to the 2019 Sinha Employment Agreement, in the event of Mr. Sinha’s death or Disability (as defined in the 2019 Sinha Employment Agreement), any unvested stock options held by him would have been accelerated in an amount equal to 25% plus 5% for each year of service to AlloVir of the number of shares subject to the option.

Pursuant to the 2019 Sinha Employment Agreement, if any payments or benefits provided to Mr. Sinha constituted “parachute payments” within the meaning of Section 280G of the Internal Revenue Code, or the Code, and any such payments were subject to the excise tax imposed by Section 4999 of the Code, Mr. Sinha’s payments would have been payable either (i) in full or (ii) reduced to such lesser amount that resulted in no portion of such payments being subject to the excise tax, whichever results in the greater after-tax benefit to Mr. Sinha.

Separation Agreement. In accordance with the terms of the Merger Agreement, effective as of the effective time of the Merger, Mr. Sinha resigned as Chief Executive Officer, President and Chief Financial Officer of AlloVir. In connection with Mr. Sinha’s resignation, AlloVir and Mr. Sinha entered into a Separation Agreement and

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Release, or the Sinha Separation Agreement. Pursuant to the terms of the Sinha Separation Agreement and to the terms of the 2019 Sinha Employment Agreement, AlloVir provided certain benefits to Mr. Sinha, including the following: (i) a lump sum in cash in an amount equal to 24 months of Mr. Sinha’s current base salary, (ii) a lump sum payment of the retention bonus of $100,000 described above, (iii) reimbursement for any monthly COBRA premium payments for up to 18 months, and (iv) acceleration of vesting of any unvested equity awards (comprising 6,045 shares (after giving effect to the Reverse Stock Split) of AlloVir RSUs). In order to receive the foregoing benefits, Mr. Sinha executed a general release in favor of AlloVir.

Brett Hagen

Retention Agreements. AlloVir entered into retention agreements with Mr. Hagen in February 2024 and May 2024, pursuant to which Mr. Hagen received retention bonuses equal to $101,720, $50,680 and $193,752, subject to Mr. Hagen’s continued employment with AlloVir through September 30, 2024. AlloVir entered into an additional retention agreement with Mr. Hagen in September 2024, pursuant to which Mr. Hagen was entitled to a monthly cash payment of $16,953 commencing October 1, 2024 until the later of (a) March 31, 2025, and (b) the consummation of the Merger, subject to Mr. Hagen’s continued employment through such date, provided, that if Mr. Hagen was terminated without cause prior to such date, Mr. Hagen was nonetheless entitled to such monthly payments through such date. If Mr. Hagen’s employment continued beyond March 31, 2025, the monthly payment would have continued at a rate of $16,953 per month or such higher amount as agreed by AlloVir.

Severance Policy. Mr. Hagen was eligible to participate in the AlloVir Executive Severance and Change of Control Policy, or the Severance Policy, pursuant to which, if (a) Mr. Hagen’s employment was terminated by AlloVir without Cause (as defined in the Severance Policy) or (b) he terminated his employment for Good Reason (as defined in the Severance Policy), in either case, within the period beginning three months prior to and ending 12 months following a Change of Control (as defined in the Severance Policy), then Mr. Hagen would have been entitled to (i) base salary payments for 12 months, or the Hagen Severance Period, provided that in the event Mr. Hagen was entitled to any payments under a restrictive covenant agreement with AlloVir, the base salary payments received in any calendar year would have been reduced by the amount he was paid in the same calendar year pursuant to the restrictive covenant agreement, (ii) a lump-sum payment equal to his target annual bonus, provided that this payment would have been reduced by the amount of any amount he was paid in the same calendar year pursuant to any restrictive covenant agreement with AlloVir, (iii) provided Mr. Hagen timely elected to continue health coverage under COBRA, reimbursement for any monthly COBRA premium payments made by Mr. Hagen until the earlier of, (A) the end of the Hagen Severance Period, and (B) the date Mr. Hagen or his spouse became eligible for health benefits through another employer or he otherwise became ineligible for COBRA, and (iv) the immediate vesting of any unvested and earned equity awards.

Payment by AlloVir of the foregoing severance amounts was contingent upon (a) Mr. Hagen executing a general release agreement in favor of AlloVir, which would have contained reasonable and customary provisions, (b) such release becoming irrevocable within the time frame set forth in the release agreement (but in no event more than 60 days following Mr. Hagen’s termination) and (c) continued compliance with post-termination restrictive covenants. Pursuant to the Severance Policy, if any payments or benefits provided to Mr. Hagen constituted “parachute payments” within the meaning of Section 280G of the Code, and any such payments were subject to the excise tax imposed by Section 4999 of the Code, Mr. Hagen’s payments would have been payable either (i) in full or (ii) reduced to such lesser amount that results in no portion of such payments being subject to the excise tax, whichever resulted in the greater after-tax benefit to Mr. Hagen.

Acknowledgement and Release. In connection with the closing of the Merger, AlloVir entered into a Severance Acknowledgement and Release with Mr. Hagen, or the Hagen Acknowledgment and Release. Pursuant to the terms of the Hagen Acknowledgment and Release and the terms of the Severance Policy, AlloVir provided certain benefits to Mr. Hagen including the following: (i) a lump sum in cash equal to 12 months of Mr. Hagen’s current base salary and annual bonus, (ii) a lump sum payment of retention bonuses of $51,381.17 described

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##### Table of Contents

above, (iii) reimbursement for any COBRA premium payments, and (iv) acceleration of vesting of any unvested equity awards (comprising 1,098 shares (after giving effect to the Reverse Stock Split) of AlloVir RSUs). In order to receive the foregoing benefits, Mr. Hagen executed a general release in favor of AlloVir.

Offer Letter. On December 17, 2024, we entered into an offer letter, or, as amended, the Hagen Offer Letter, with Mr. Hagen in connection with his continued employment as our Chief Accounting Officer, which was amended on April 15, 2025. Pursuant to the Hagen Offer Letter, Mr. Hagen receives an annualized base salary of $400,000 and is eligible to receive an annual performance bonus of up to 35% of his base salary, or the Hagen Target Bonus, as determined by the board of directors. Mr. Hagen is also eligible to participate in our employee benefits plans, subject to the terms of those plans.

Under the Hagen Offer Letter, if more than three months prior to or more than 12 months following a “change in control” (as defined in the Hagen Offer Letter) of the company, Mr. Hagen’s employment is terminated by us without “cause” or by him for “good reason” (each as defined in the Hagen Offer Letter), Mr. Hagen is entitled to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the “restrictive covenant agreements” (as defined in the Hagen Offer Letter) and any similar agreements with us, (i) continued payment of his base salary for a period of nine months following his termination date, and (ii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to nine months.

Furthermore, if, within three months prior to or within 12 months following a change in control of the company, Mr. Hagen’s employment is terminated by us without cause or by him for good reason, Mr. Hagen is entitled to, subject to (a) his execution of a severance and release of claims agreement in favor of the company, which agreement must become irrevocable within 60 days following his termination (or such shorter period as may be directed by us), and (b) his continued compliance with the restrictive covenant agreements and any similar agreements with us, (i) continued payment of his base salary for a period of 12 months following his termination date, (ii) a lump-sum payment equal to 100% of the Hagen Target Bonus for the year in which his termination occurs or, if higher, the Hagen Target Bonus immediately prior to the change in control, (iii) provided that he is eligible for and timely elects to continue receiving group medical insurance pursuant to COBRA, continued payment of the share of the premiums for health coverage that is paid by us for a period of up to 12 months, and (iv) the acceleration of his then-unvested equity awards that vest based solely on the passage of time, such that all such then-unvested equity awards immediately vest and become fully exercisable or non-forfeitable as of his termination date.

401(k) Plan

We maintain a 401(k) retirement savings plan for our U.S.-based employees who satisfy certain eligibility requirements. The 401(k) plan is intended to qualify as a tax-qualified plan under the Code. The Code allows eligible employees to defer a portion of their compensation, within prescribed limits, on a pre-tax basis through contributions to the 401(k) plan.

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##### Table of Contents

Policies and Practices Related to the Grant of Certain Equity Awards
We grant stock options to our employees and
non-employee
directors on an annual basis. We may also grant stock options to individuals upon hire or promotion or for retention purposes. We currently do not grant stock appreciation rights or similar option-like instruments. We have established practices regarding the timing of stock option, stock appreciation rights and similar option-like instrument grants in relation to the release of material nonpublic information, or MNPI. Our board of directors determines the timing of such awards based on several factors, including our financial performance, market conditions, transactions, and individual performance metrics on an annual basis. Our board of directors takes into account MNPI when determining the timing and terms of an award to ensure that grants are not made in close proximity to the release of such information, including at any time during the period beginning four business days before and ending one business day after the filing of any Form
10-Q
or
10-K,
or the filing or furnishing of a Form
8-K
that discloses MNPI. Additionally, we do not time the disclosure of MNPI for the purpose of affecting the value of executive compensation.
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##### Table of Contents

Director Compensation

At the effective time of the Merger, a majority of the AlloVir directors resigned, with the exception of David Hallal and Morana Jovan-Embiricos, and the remaining director vacancies were replaced by new directors designated by Legacy Kalaris. Accordingly, we have provided the compensation disclosure with respect to all directors of AlloVir that served during 2025, for those non-employee directors of Legacy Kalaris that were appointed to our board of directors in connection with the Merger and our non-employee directors that were appointed to our board of directors in 2025 following the closing of the Merger.

The table below shows all compensation to such non-employee directors during the year ended December 31, 2025. Andrew Oxtoby, our President and Chief Financial Officer, and Vikas Sinha, AlloVir’s former Chief Executive Officer, President and Chief Financial Officer, received no compensation for their service as directors, and, consequently, are not included in this table. The compensation received by Mr. Oxtoby and Mr. Sinha during the year ended December 31, 2025 is presented in “Executive Compensation—Summary Compensation Table” above.

2025 Director Compensation Table

Name |  | Fees Earned or Paid in Cash ($) |  |  | Option Awards ($)(1)(2) |  |  | All Other Compensation ($) |  |  | Total ($) |
Derek Adams, Ph.D.(3) |  |  | 13,125 |  |  |  | — |  |  |  | — |  |  |  | 13,125 |
Jeffrey S. Bornstein(3) |  |  | 16,875 |  |  |  | — |  |  |  | — |  |  |  | 16,875 |
Malcolm Brenner, M.D., Ph.D.(3) |  |  | 12,500 |  |  |  | — |  |  |  | — |  |  |  | 12,500 |
David Hallal |  |  | 140,000 |  |  |  | 104,430 |  |  |  | — |  |  |  | 244,430 |
Morana Jovan-Embiricos, Ph.D. |  |  | 51,875 |  |  |  | 104,430 |  |  |  | — |  |  |  | 156,305 |
Shawn Tomasello(3) |  |  | 13,750 |  |  |  | — |  |  |  | — |  |  |  | 13,750 |
Juan Vera, M.D. (3) |  |  | 10,000 |  |  |  | — |  |  |  | — |  |  |  | 10,000 |
Anthony P. Adamis, M.D. |  |  | 35,625 |  |  |  | 104,430 |  |  |  | 1,850 | (4) |  |  | 141,905 |
Srinivas Akkaraju, M.D., Ph.D. |  |  | 36,000 |  |  |  | 104,430 |  |  |  | — |  |  |  | 140,430 |
Michael Dybbs, Ph.D. |  |  | 39,000 |  |  |  | 104,430 |  |  |  | — |  |  |  | 143,430 |
Napoleone Ferrara, M.D. |  |  | 33,000 |  |  |  | 104,430 |  |  |  | 13,663 | (5) |  |  | 151,093 |
Samir Patel, M.D.(6) |  |  | — |  |  |  | 104,430 |  |  |  | 44,000 | (7) |  |  | 148,430 |
Leone Patterson (8) |  |  | 41,250 |  |  |  | 104,430 |  |  |  | — |  |  |  | 145,680 |

(1) | The amounts reported represent the aggregate grant date fair value of the stock options in 2025, calculated in accordance with FASB ASC, Topic 718. The assumptions used in calculating the grant date fair value of the stock options reported in this column are set forth in Note 13 to our audited financial statements included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025. In accordance with the terms of the Merger Agreement, as of immediately prior to the effective time of the Merger each unexercised and outstanding AlloVir stock option with an exercise price per share equal to or greater than $92.00 (after giving effect to the Reverse Stock Split) was cancelled for no consideration and all other unexpired, unexercised and unvested AlloVir stock options were accelerated in full.

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##### Table of Contents

(2) | The aggregate amount of outstanding options held by each non-employee director as of December 31, 2025 were as follows:

Name |  | Aggregate Options Outstanding (#) |
Derek Adams, Ph.D. |  |  | — |
Jeffrey S. Bornstein |  |  | — |
Malcolm Brenner, M.D., Ph.D. |  |  | — |
David Hallal |  |  | 18,000 |
Morana Jovan-Embiricos, Ph.D. |  |  | 18,000 |
Shawn Tomasello |  |  | — |
Juan Vera, M.D. |  |  | — |
Anthony P. Adamis, M.D. |  |  | 50,473 |
Srinivas Akkaraju, M.D., Ph.D. |  |  | 18,000 |
Michael Dybbs, Ph.D. |  |  | 18,000 |
Napoleone Ferrara, M.D. |  |  | 18,000 |
Samir Patel, M.D. |  |  | 123,913 |
Leone Patterson |  |  | 18,000 |

(3) | Each of Dr. Adams, Mr. Bornstein, Dr. Brenner, Mr. Tomasello and Dr. Vera served as directors of AlloVir and resigned upon consummation of the Merger.

(4) | Reflects reimbursement of certain expenses.

(5) | Reflects (i) $12,500 in consulting fees paid to Dr. Ferrara in 2025 pursuant to a consulting agreement with us and (ii) reimbursement of certain expenses. For further information about our consulting agreement with Dr. Ferrara, see “Certain Related-Person Transactions” below.

(6) | Dr. Patel resigned from our board of directors effective May 13, 2025.

(7) | Reflects consulting fees paid to Dr. Patel in 2025 pursuant to a consulting agreement with us.

(8) | Ms. Patterson was elected to our board of directors effective April 3, 2025.

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##### Table of Contents

Director Compensation Policy Prior to the Merger

In connection with AlloVir’s initial public offering, the AlloVir board of directors adopted a non-employee director compensation policy that was designed to provide a total compensation package that enabled AlloVir to attract and retain, on a long-term basis, high caliber non-employee directors. Under the policy, as amended in May 2023, all non-employee directors, prior to the closing of the Merger, were paid cash compensation, as set forth below:

|  | Annual Retainer ($) |
Board of Directors: |  |  |  |
All non-employee members |  |  | 40,000 |
Chairman |  |  | 160,000 |
Audit Committee: |  |  |  |
Chairman |  |  | 20,000 |
Non-Chairman members |  |  | 10,000 |
Compensation Committee: |  |  |  |
Chairman |  |  | 15,000 |
Non-Chairman members |  |  | 7,500 |
Nominating and Corporate Governance Committee: |  |  |  |
Chairman |  |  | 10,000 |
Non-Chairman members |  |  | 5,000 |

Under the policy, upon initial election or appointment to the AlloVir board of directors, new non-employee directors received a one-time stock option grant to purchase 1,956 shares of the AlloVir’s common stock, which vested in equal quarterly installments over three years. In each subsequent year of a non-employee director’s tenure, the director received an annual equity grant of 1,521 RSUs, which vested in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual meeting of stockholders. The exercise price of the initial option awards was equal to the fair market value of the AlloVir common stock, as measured by reference to market quotations on Nasdaq, as of the grant date. Vesting of any equity award ceased if a director resigned from the AlloVir board of directors or otherwise ceased to serve as a director, unless the AlloVir board of directors determined that circumstances warranted continuation of vesting.

In addition, each non-employee director was paid an annual retainer for their services on the AlloVir board of directors and, if applicable, for serving on committees of the AlloVir board of directors, in each case, as set forth in the table above. Such cash retainers were paid quarterly, and could be pro-rated based on the number of actual days served by the director during such calendar quarter.

Director Compensation Policy Following the Merger

On April 10, 2025, we adopted a non-employee director compensation policy. Under our new non-employee director compensation policy, we pay our non-employee directors a cash retainer for service on the board of directors and for service on each committee on which the director is a member. The Chair of the board of directors and each committee receives higher retainers for such service. We also make initial and annual equity awards to our non-employee directors and reimburse them for reasonable travel and other expenses incurred in connection with attending meetings of our board of directors and any committee of our board of directors on which they serve.

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##### Table of Contents

Under our non-employee director compensation policy, each non-employee director is entitled to receive an annual cash retainer of $40,000 for serving on our board of directors. The Chair of the board is also entitled to receive an annual cash retainer of $110,000. The chairs and the members of the following three committees of our board of directors are entitled to receive the following additional annual cash retainers:

Board Committee |  | Member Annual Retainer |  | Chair Incremental Annual Retainer
Audit Committee |  |  | $ | 7,500 |  |  |  | $ | 7,500 |
Compensation Committee |  |  |  | 6,000 |  |  |  |  | 6,000 |
Nominating and Corporate Governance Committee |  |  |  | 4,000 |  |  |  |  | 4,000 |

All annual cash retainers are payable in arrears in four equal quarterly installments on the last day of each fiscal quarter, provided that (i) the amount of such payment is prorated for any portion of such quarter (based on the number of days served in the applicable quarter) that the director is not serving on the board, on such committee or in such position, and (ii) no retainer will be payable in respect of any period prior to March 18, 2025 and the first payment will be prorated.

In addition, each non-employee director receives, upon his or her initial election or appointment to our board of directors, an option to purchase 18,000 shares of our common stock. The initial award will have a term of ten years and will vest as to 2.7778% of the shares underlying such award at the end of each successive one-month period following the grant date until the third anniversary of the grant date, subject to the director’s continued service to us through the applicable vesting date. The vesting will accelerate to 100% of the shares upon a change of control of the company. The exercise price will be the closing price of our common stock as reported on Nasdaq on the date of grant.

Beginning with the Annual Meeting, each non-employee director will be granted an option to purchase 9,000 shares of our common stock; provided that for a non-employee director who was initially elected to our board of directors within the one year preceding the annual meeting of stockholder, the number of shares subject to such award will be prorated based on the number of days served by such director during the preceding year. The annual award will have a term of ten years and will vest in full on the one-year anniversary of the grant date (or, if earlier, the date immediately prior to the date of the first annual meeting of stockholders occurring after the grant date), subject to the director’s continued service to us through such applicable vesting date. The vesting will accelerate as to 100% of the shares upon a change in control of the company. The exercise price will be the closing price of our common stock as reported on Nasdaq on the date of grant.

In April 2025, each non-employee director was granted an option to purchase 18,000 shares of our common stock. Each of these options vest over three years in equal monthly installments from March 18, 2025 to March 18, 2028, subject to continuous service.

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##### Table of Contents

Securities Authorized for Issuance Under Our Equity Compensation Plans

The following table provides information about the securities authorized for issuance under our equity compensation plans as of December 31, 2025. As of December 31, 2025, we had four equity compensation programs: our 2018 Stock Incentive Plan, or the 2018 Plan, our 2019 Equity Incentive Plan, or the 2019 Plan, the 2020 Plan and the 2020 Employee Stock Purchase Plan, or the ESPP. Each of the 2018 Plan, the 2020 Plan and the ESPP, was approved by AlloVir’s stockholders. The 2019 Plan was approved by Legacy Kalaris’ stockholders and, at the effective time of the Merger, we assumed the 2019 Plan and each outstanding Legacy Kalaris option granted under the 2019 Plan.

Plan Category |  | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) |  | Weighted- average exercise price of outstanding options, warrants and rights (b) |  | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (c)
Equity compensation plans approved by securityholders (1) |  |  |  | 2,142,278 |  |  |  | $ | 3.98 |  |  |  |  | 1,429,729(2) |
Equity compensation plans not approved by securityholders |  |  |  | — |  |  |  | $ | — |  |  |  |  | — |
Total |  |  |  | 2,142,278 |  |  |  | $ | 3.98 |  |  |  |  | 1,429,729(3) |

(1) | These plans consist of the 2018 Plan, the 2019 Plan, the 2020 Plan and the ESPP.

(2) | As of December 31, 2025, (i) 396,646 shares remained available for future issuance under the 2019 Plan, (ii) 913,757 shares remained available for future issuance under the 2020 Plan and (iii) 119,326 shares remained available for future issuance under the ESPP. No shares remained available for future issuance under the 2018 Plan as of December 31, 2025. The 2020 Plan has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the 2020 Plan to be added on the first day of each fiscal year, starting with fiscal year 2021, in an amount equal to 5% of the number of shares of our common stock outstanding on the immediately preceding December 31 or such lesser amount determined by the board of directors or the compensation committee of the board of directors. The ESPP has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the ESPP to be added on the first day of each fiscal year, starting in fiscal year 2021, in an amount equal to the least of 1% of the total number of shares of our common stock outstanding on the immediately preceding December 31, 53,161 shares of our common stock, or such lesser amount determined by the board of directors or the compensation committee of the board of directors.

(3) | This amount excludes 1,145,120 shares of common stock that became issuable under the 2020 Plan on January 1, 2026, pursuant to the evergreen provisions of the 2020 Plan, and 53,161 shares of common stock that became issuable under the ESPP on January 1, 2026, pursuant to the evergreen provisions of the ESPP.

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##### Table of Contents

Pay Versus Performance
The following tables and related disclosures provide information about (i) the “total compensation” of our principal executive officers, or PEOs, and our other named executive officers, or the Other NEOs, as presented in the Summary Compensation Table on page 28 of this proxy statement, or the SCT Amounts, (ii) the “compensation actually paid” to our PEOs and our Other NEOs, as calculated pursuant to the SEC’s
pay-versus-performance
rules, or the CAP Amounts, (iii) certain financial performance measures, and (iv) the relationship of the CAP Amounts to those financial performance measures.
This disclosure has been prepared in accordance with Item 402(v) of Regulation
S-K
under the Exchange Act and does not necessarily reflect value actually realized by the executives or how our compensation committee evaluates compensation decisions in light of company or individual performance.

|  | Oxtoby, Andrew |  | Sinha, Vikas |  | Brainard, Diana |  |  |  |  |  |  |  |
Fiscal Year |  | Summary Compensation Table Total for PEO (1) |  | Compensation Actually Paid to PEO (2) |  | Summary Compensation Table Total for PEO (1) |  | Compensation Actually Paid to PEO (2) |  | Summary Compensation Table Total for PEO (1) |  | Compensation Actually Paid to PEO (2) |  | Average Summary Compensation Table Total for Non- PEO Named Executive Officers (1) |  | Average Compensation Actually Paid to Non- PEO Named Executive Officers (2) |  | Value of Initial Fixed $100 Investment Based on: Total Shareholder Return |  | Net Income (Loss) (in thousands)
2025 |  |  | $ | 2,569,115 |  |  |  | $ | 4,509,544 |  |  |  | $ | 1,100,954 |  |  |  | $ | 1,097,848 |  |  |  |  | — |  |  |  |  | — |  |  |  | $ | 1,392,517 |  |  |  | $ | 1,725,759 |  |  |  | $ | 54 |  |  |  | ($ | 43,432 | )
2024 |  |  |  | — |  |  |  |  | — |  |  |  | $ | 544,400 |  |  |  | $ | 456,150 |  |  |  | $ | 3,028,669 |  |  |  | $ | 2,830,341 |  |  |  | $ | 721,002 |  |  |  | $ | 684,351 |  |  |  | $ | 62 |  |  |  | ($ | 69,167 | )

(1) | For 2025, the PEOs were Andrew Oxtoby and Vikas Sinha and the Other NEOs were Matthew Feinsod, Matthew Gall and Brett Hagen. For 2024, the PEOs were Vikas Sinha and Diana Brainard, AlloVir’s former Chief Executive Officer, and the Other NEOs were Edward Miller, AlloVir’s General Counsel, and Brett Hagen. Effective as of December 19, 2024, the AlloVir board of directors determined that Dr. Brainard would no longer serve as Chief Executive Officer of AlloVir. On March 18, 2025, in accordance with the terms of the Merger Agreement, effective as of the effective time of the Merger, Mr. Miller resigned as General Counsel and Secretary of AlloVir.

(2) | The following table describes the adjustments, each of which is prescribed by SEC rule, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during the applicable years, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act.

43

Adjustments |  | 2025 |  |  | 2024 |
| Oxtoby, Andrew |  |  | Sinha, Vikas |  |  | Other NEOs* |  |  | Sinha, Vikas |  |  | Brainard, Diana |  |  | Other NEOs* |
Summary Compensation Table (SCT) Total |  | $ | 2,569,115 |  |  | $ | 1,100,954 |  |  | $ | 1,392,517 |  |  | $ | 544,400 |  |  | $ | 3,028,669 |  |  | $ | 721,002 |
Subtract: Aggregate value for stock awards and option awards included in SCT Amounts for the covered fiscal year |  | $ | 1,687,076 |  |  |  | — |  |  | $ | 751,033 |  |  |  | — |  |  |  | — |  |  |  | — |
Add: Fair value at year end of awards granted during the covered fiscal year that were outstanding and unvested at the covered fiscal year end |  | $ | 1,884,171 |  |  |  | — |  |  | $ | 1,041,428 |  |  |  | — |  |  |  | — |  |  |  | — |
Add (Subtract): Year-over-year change in fair value at covered fiscal year end of awards granted in any prior fiscal year that were outstanding and unvested at the covered fiscal year end |  | $ | 1,553,813 |  |  |  | — |  |  | $ | 38,993 |  |  | ($ | 90,091 | ) |  |  | — |  |  | ($ | 37,901 | )
Add (Subtract): Change as of the vesting date (from the end of the prior fiscal year) in fair value of awards granted in any prior fiscal year for which vesting conditions were satisfied during the covered fiscal year |  | $ | 189,522 |  |  | ($ | 3,107 | ) |  | $ | 3,854 |  |  | $ | 1,841 |  |  | ($ | 198,328 | ) |  | $ | 1,250 |
Compensation Actually Paid (as calculated) |  | $ | 4,509,544 |  |  | $ | 1,097,848 |  |  | $ | 1,725,759 |  |  | $ | 456,150 |  |  | $ | 2,830,341 |  |  | $ | 684,351 |

* | Amounts presented are averages for the entire group of Other NEOs in each respective year.

For the equity values included in the above tables, the valuation assumptions used to calculate fair values of stock options were materially different from those disclosed at the time of the grant of the stock options. The assumptions used in determining fair value of the stock options that vested during 2025 and 2024, or that were outstanding as of December 31, 2025 or December 31, 2024, as applicable, are as follows:

|  | Options Vested During Year or Outstanding on December 31 of: |
|  | 2025 |  |  | 2024 |
Expected Volatility |  |  | 90.16% - 116.1% |  |  |  | 101.74% - 113.39% |
Risk-Free Interest Rate |  |  | 3.53% - 4.38% |  |  |  | 3.55% - 4.81% |
Expected Dividend Yield |  |  | 0.00% |  |  |  | 0.00% |
Expected Term (in years) |  |  | 2.53 - 6.85 |  |  |  | 2.79 - 6.51 |

44

Description of Relationship Between NEO Compensation Actual
ly Pai
d and Company Total Shareholder Return (“TSR”)
The following chart sets forth the relationship between the CAP Amounts to our PEO, the average of CAP Amounts to our Other NEOs, and our TSR over the fiscal two year period from 2024 through 2025.
Description of Relationship Between NEO Compensation Actually Paid and Net Income/(Loss)
The following chart sets forth the relationship between CAP Amounts to our PEO, the average of CAP Amounts to our Other NEOs, and our Net Income (Loss) over the fiscal two year period from 2024 through 2025.
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##### Table of Contents

CERTAIN RELATED-PERSON TRANSACTIONS

Other than the compensation arrangements for our named executive officers, which are described elsewhere in this proxy statement, below are transactions since January 1, 2024 in which we have participated or will be a participant and:

| • |  | the amounts involved exceeded or will exceed $120,000; and

| • |  | any of our directors, executive officers or holders of more than 5% of our voting securities, or any member of the immediate family of, or person sharing the household with, the foregoing persons, had or will have a direct or indirect material interest.

Legacy Kalaris Transactions

The share and per share amounts included in this section relate to Legacy Kalaris prior to the closing of the Merger and do not give effect to the exchange of shares at the closing of the Merger based upon the Exchange Ratio.

Issuances of Legacy Kalaris Securities

May 2023 Financing

In May 2023, Legacy Kalaris issued to Samsara LP a convertible promissory note, or the May 2023 Note, with an aggregate principal amount of up to $6.0 million, of which $3.0 million was initially advanced to Legacy Kalaris on May 15, 2023. The May 2023 Note accrued interest on the initial advance commencing on the date of such advance, at an interest rate of 8.0% per annum. In connection with Legacy Kalaris’ Series B preferred stock financing in October 2023, all outstanding principal and accrued interest under the May 2023 Note converted into an aggregate of 3,091,397 shares of Series B-1 preferred stock, $0.00001 par value per share, of Legacy Kalaris, or the Legacy Kalaris Series B-1 Preferred Stock, at a price per share equal to $1.00.

SAFE Financing

In August 2023, Legacy Kalaris issued to Samsara LP a Simple Agreement for Future Equity with an aggregate principal amount of $1.5 million, or the SAFE. In connection with Legacy Kalaris’ Series B preferred stock financing in October 2023, the SAFE converted into an aggregate of 1,200,000 shares of Series B-2 preferred stock, $0.00001 par value per share, of Legacy Kalaris, or the Legacy Kalaris Series B-2 Preferred Stock, at a price per share equal to $1.25.

Series B Preferred Stock Financing

In October 2023 and January 2024, Legacy Kalaris (i) issued 9,957,095 shares of Series B-1 Preferred Stock upon conversion of outstanding Legacy Kalaris convertible notes, including a convertible note issued to Samsara LP in December 2022 and the May 2023 Note, with an aggregate principal amount of approximately $9.5 million, at a conversion price of $1.00 per share, (ii) issued and sold 6,800,000 shares of Series B-2 Preferred Stock at a purchase price of $1.25 per share, for aggregate gross proceeds of $8.5 million, and (iii) issued 1,200,000 shares of Legacy Kalaris Series B-2 Preferred Stock upon conversion of the SAFE at a conversion price of $1.25 per share.

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The following table sets forth the aggregate number of shares of Legacy Kalaris Series B-1 Preferred Stock and Legacy Kalaris Series B-2 Preferred Stock that were issued to Samsara LP and the aggregate amount of consideration for such shares:

Purchaser |  | Shares of Legacy Kalaris Series B-1 Preferred Stock Issued upon Conversion of Convertible Notes |  | Principal and Accrued Interest of Convertible Notes ($) |  | Shares of Legacy Kalaris Series B-2 Preferred Stock Purchased for Cash |  | Total Cash Purchase Price ($) |  | Shares of Legacy Kalaris Series B-2 Preferred Stock Issued upon Conversion of SAFE |  | Principal of SAFE Investment ($)
Samsara BioCapital, L.P. |  |  |  | 9,957,095 |  |  |  | $ | 9,957,095 |  |  |  |  | 2,800,000 |  |  |  | $ | 3,500,000 |  |  |  |  | 1,200,000 |  |  |  | $ | 1,500,000 |

(1) | Samsara LP beneficially owned more than 5% of Legacy Kalaris’ outstanding capital stock. Each of Dr. Akkaraju and Dr. Dybbs was a member of the Legacy Kalaris board of directors, and (i) Dr. Akkaraju is the founder and managing general partner of Samsara LP, and was deemed to beneficially own greater than 5% of the outstanding capital stock of Legacy Kalaris, and (ii) Dr. Dybbs is a partner of Samsara LP.

March 2024 Financing

In March 2024, Legacy Kalaris issued to Samsara LP a convertible promissory note, or the March 2024 Note, with an aggregate principal amount of $10.0 million, of which $5.0 million was initially advanced to Legacy Kalaris on March 12, 2024 and the remaining $5.0 million was subsequently advanced to Legacy Kalaris on May 28, 2024. The March 2024 note accrued interest on the initial advance and the subsequent advance commencing on the date of each such advance, at an interest rate of 10.0% per annum. Unless earlier converted or repaid, all outstanding principal and accrued interest under the March 2024 Note would become due and payable upon demand by Samsara LP, at any time on or after March 12, 2025.

In connection with the closing of the Merger, the outstanding principal and accrued interest under the March 2024 Note was converted into 1,757,951 shares of Legacy Kalaris common stock at a conversion rate of $6.20 per share (as adjusted to reflect the Reverse Stock Split).

October 2024 Financing

In October 2024, Legacy Kalaris entered into a Note Purchase Agreement with Samsara LP, or the Note Purchase Agreement, pursuant to which Legacy Kalaris could have issued notes in the aggregate principal amount of up to $25.0 million.

In October 2024, pursuant to the Note Purchase Agreement, Legacy Kalaris issued to Samsara LP a convertible promissory note, or the Samsara October 2024 Note, with an aggregate principal amount of $8,957,159. We refer to such October 2024 issuance of the Samsara October 2024 Note as the Initial First Tranche Closing.

In November 2024, pursuant to the Note Purchase Agreement, Legacy Kalaris issued additional notes with an aggregate principal amount of $1,042,841 to existing preferred stockholders of Legacy Kalaris, including a convertible promissory note with an aggregate principal amount of $115,871 issued to Samsara LP, or the Samsara November 2024 Note, and collectively, with the Samsara October 2024 Note and the Samsara November 2024 Note, and the other notes issued to existing Legacy Kalaris stockholders in November 2024, the 2024 Bridge Notes. We refer to the November issuance of convertible notes as the Final First Tranche Closing, and together with the Initial First Tranche Closing, the Initial Permitted Bridge Financing.

In January 2025, Legacy Kalaris and the parties named therein amended the Note Purchase Agreement, or, as amended, the Amended Note Purchase Agreement. Pursuant to the Amended Note Purchase Agreement, each purchaser that purchased notes in the Initial Permitted Bridge Financing committed to purchase additional notes,

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upon written notice from Legacy Kalaris and subject to Samsara LP’s consent, in an aggregate principal amount set forth in the Amended Note Purchase Agreement (up to the maximum aggregate amount, to be purchased by all purchasers, of $15.0 million).

Legacy Kalaris was eligible to receive additional proceeds under the Amended Note Purchase Agreement prior to the closing of the Merger to fund Legacy Kalaris’ operations prior to the closing to be provided by Legacy Kalaris’ stockholders at three subsequent closings upon Legacy Kalaris’ written notice to investors and subject to Samsara LP’s consent.

In January 2025, pursuant to the Amended Note Purchase Agreement, Legacy Kalaris issued additional notes with an aggregate principal amount of $3,750,000 to existing Legacy Kalaris stockholders, including a convertible promissory note with an aggregate principal amount of $31,285.50 issued to Samsara LP, or the Samsara January 2025 Note, collectively with the Samsara January 2025 Note and the other notes issued to existing Legacy Kalaris stockholders in January 2025, the January 2025 Bridge Notes, and together with the 2024 Bridge Notes, the Bridge Notes.

In connection with the closing of the Merger, the outstanding principal and accrued interest under the 2024 Bridge Notes was converted into 1,660,888 shares of Legacy Kalaris common stock at a conversion price of $6.20 per share (as adjusted to reflect the Reverse Stock Split). Additionally, the outstanding principal and accrued interest under the January 2025 Bridge Notes was converted into 794,499 shares of Legacy Kalaris Series B-2 Preferred Stock at a price of $4.7851 per share, which then converted on a one-for-one basis into shares of Legacy Kalaris common stock, and subsequently into 160,165 shares of common stock (as adjusted to reflect the Reverse Stock Split).

AlloVir Note

Also in January 2025, pursuant to the Amended Note Purchase Agreement, Legacy Kalaris issued a convertible promissory note in an aggregate principal amount of up to $7.5 million to AlloVir, or the AlloVir Note, under which AlloVir funded a principal amount of $3.75 million in January 2025. The AlloVir Note accrued interest on the initial advance commencing on the date of such advance, at an interest rate of 8.0% per annum. Unless earlier converted or repaid (as discussed below), all outstanding principal and accrued interest under the AlloVir Note would have become due and payable upon demand by AlloVir at any time on or after the date that was one hundred eight (180) days after the date on which the Merger Agreement was terminated in accordance with its terms. In the event of a termination of the Merger Agreement, Legacy Kalaris would have been obligated to repay the AlloVir Note upon demand by AlloVir on repayment terms that were to be mutually agreed by Legacy Kalaris and AlloVir (provided that such repayment would occur no sooner than 180 days following such termination). If the Merger Agreement was terminated in connection with the occurrence of any company triggering event (as defined in the Merger Agreement) or a superior offer (as defined in the Merger Agreement) under specified circumstances, AlloVir had the option, in its sole discretion, to elect repayment or to convert the amount outstanding (including accrued interest) under the AlloVir Note into shares of Legacy Kalaris common stock at a price per share equal to the company per share value (as defined in the Merger Agreement), rounded down to the nearest whole share. Immediately prior to the closing of the Merger, the AlloVir Note was cancelled.

Consulting Agreement with Napoleone Ferrara

Since July 2021, Dr. Ferrara, who served as a member of the Legacy Kalaris board of directors and currently serves as a member of our board of directors, earns $50,000 per year pursuant to the terms of a consulting agreement he entered into with Legacy Kalaris on July 1, 2021 unrelated to his service as a member of the Legacy Kalaris board of directors. Under the consulting agreement, Dr. Ferrara provides an average of one to three hours per week of scientific, technical and medical advice to the Company to support the Company’s research and development activities. The consulting agreement with Dr. Ferrara, who serves as a member of our board of directors, remains in place following the closing of the Merger.

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Services Provided by Samsara

Since Legacy Kalaris’ inception, Samsara LP has provided in-kind research and development and general and administrative services to Legacy Kalaris. From April 2022, Samsara LP also provided general and administrative services for cash consideration related to (1) accounting and controllership, (2) human resources and (3) executive assistance. In July 2023, Legacy Kalaris and Samsara entered into a Business Services Agreement, or the BSA, that governs the provision of such services. The BSA has a term of five years and may be terminated upon 15 days’ written notice by either party. The BSA remains in effect following the closing of the Merger. We recognized $288,826 as general and administrative expenses for the year ended December 31, 2025, related to the services provided by Samsara LP under the BSA.

Royalty Agreement

In July 2024, Legacy Kalaris entered into a royalty agreement, or the Royalty Agreement, with Samsara LP. Under the Royalty Agreement, Legacy Kalaris redeemed 50,000 shares of its common stock issued to Samsara LP under a founders restricted stock purchase agreement with Samsara LP in exchange for Legacy Kalaris’ agreement to pay Samsara LP a low single digit percentage tiered royalty on net sales, if any, of the Company’s products developed using the technology licensed under the license agreement with the Regents of the University of California, San Diego. Such royalties are payable on a product-by-product and country-by-country basis until the later of (i) ten years after the first commercial sale of such product in such country and (ii) the expiration of the last-to-expire issued claim of our patents for such product in such country. The Royalty Agreement remains in effect following the closing of the Merger.

2025 Private Placement

On December 17, 2025, we entered into a securities purchase agreement with certain institutional accredited investors, or the PIPE Investors, pursuant to which we issued and sold to the PIPE Investors in a private placement an aggregate of 4,200,000 shares of our common stock, or PIPE Shares, at a price of $10.00 per PIPE Share and, to certain PIPE Investors in lieu of PIPE Shares, pre-funded warrants to purchase 800,000 shares of our common stock, or Pre-Funded Warrants, at a price of $9.9999 per Pre-Funded Warrant, for aggregate gross proceeds of approximately $50.0 million, which we refer to collectively as the 2025 Private Placement. The following table sets forth the number of PIPE Shares and Pre-Funded Warrants purchased by holders of more than 5% of our voting securities at the time of the 2025 Private Placement, and the aggregate purchase price paid for such securities.

Name (1) |  | Number of Shares of Common Stock |  | Number of Pre-Funded Warrants |  | Aggregate Purchase Price
Samsara Opportunity Fund, L.P. |  |  |  | 1,500,000 |  |  |  |  | — |  |  |  | $ | 15,000,000 |
Entities affiliated with RTW Master Fund, LTD(2) |  |  |  | 1,300,000 |  |  |  |  | — |  |  |  | $ | 13,000,000 |

(1) | See the section entitled, “Stock Ownership and Reporting - Security Ownership of Certain Beneficial Owners and Management” for additional information about securities held by certain of these entities.

(2) | Became a beneficial holder of more than 5% of our outstanding voting securities upon the closing of the 2025 Private Placement.

Indemnification Agreements

Our restated certificate of incorporation provides that we may indemnify our directors to the maximum extent permitted by the Delaware General Corporation Law, or DGCL, and our amended and restated by-laws provide that we will indemnify our directors and officers and may indemnify our other employees and other agents to the maximum extent permitted by the DGCL. In addition, we have entered into and expect to continue to enter into agreements to indemnify our directors and executive officers.

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Policies and Procedures for Related Party Transactions

Our board of directors has adopted written policies and procedures for the review of any transaction in which our company is a participant, the amount involved exceeds $120,000, and one of our executive officers, directors, director nominees or holders of more than 5% of our voting securities (or their immediate family members), each of whom we refer to as a “related person,” has a direct or indirect material interest.

Pursuant to this policy, the audit committee has the primary responsibility for reviewing and approving or disapproving such transactions, which we refer to as “related person transactions.” Wherever practicable, the review will occur prior to entry into the transaction. If advance review is not practicable, the audit committee will review the related person transaction at the audit committee’s next regularly scheduled meeting. In reviewing any related person transaction, the audit committee will take into account, among other factors that it deems appropriate, whether the related person transaction is on terms no less favorable to us than terms generally available in a transaction with an unaffiliated third-party under the same or similar circumstances, and the extent of the related person’s interest in the related person transaction. In connection with its review, we will provide the audit committee with all material information regarding such related person transaction, the interest of the related person and any potential disclosure obligations in connection with such related person transaction.

If any related person transaction will be ongoing, the audit committee may establish guidelines for our management to follow in its ongoing dealings with the related person. The audit committee will review and assess, on at least an annual basis, such related person transaction and confirm that the ongoing dealings with such related person have been in compliance with the guidelines established by the audit committee.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth information with respect to the beneficial ownership of our common stock as of April 1, 2026 by:

| • |  | each of our directors;

| • |  | each of our named executive officers;

| • |  | all of our executive officers and directors as a group; and

| • |  | each person, or group of affiliated persons, who is known by us to beneficially own more than 5% of our common stock.

The percentage of shares beneficially owned is based on a total of 22,992,291 shares of our common stock outstanding as of April 1, 2026.

Beneficial ownership is determined in accordance with the rules and regulations of the SEC and includes voting or investment power with respect to our common stock. Shares of our common stock that an individual has a right to acquire within 60 days after April 1, 2026 are considered outstanding and beneficially owned by the person holding such right for the purpose of calculating the percentage ownership of that person but not for the purpose of calculating the percentage ownership of any other person, except with respect to the percentage ownership of all directors and executive officers. Except as otherwise noted, the persons and entities in this table have sole voting and investing power with respect to all of the shares of our common stock beneficially owned by them, subject to community property laws, where applicable. Unless otherwise indicated, the address of each beneficial owner is c/o Kalaris Therapeutics, Inc., 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922.

Name of Beneficial Owners |  | Number of Shares Beneficially Owned |  | Percentage Beneficially Owned
5% Stockholders |  |  |  |  |  |  |  |  |  |
Entities affiliated with Samsara BioCapital, L.P.(1) |  |  |  | 12,948,081 |  |  |  |  | 56.3 | %
Entities affiliated with RTW Investments LP(2) |  |  |  | 1,300,000 |  |  |  |  | 5.7 | %
Named Executive Officers and Directors |  |  |  |  |  |  |  |  |  |
Andrew Oxtoby(3) |  |  |  | 341,877 |  |  |  |  | 1.5 | %
Matthew Feinsod(4) |  |  |  | 69,899 |  |  |  |  | * |
Matthew Gall |  |  |  | — |  |  |  |  | * |
Brett Hagen(5) |  |  |  | 14,660 |  |  |  |  | * |
Vikas Sinha(6) |  |  |  | 774,118 |  |  |  |  | 3.4 | %
Anthony P. Adamis, M.D.(7) |  |  |  | 39,473 |  |  |  |  | * |
Srinivas Akkaraju, M.D., Ph.D.(8) |  |  |  | 12,955,081 |  |  |  |  | 56.3 | %
Michael Dybbs, Ph.D.(9) |  |  |  | 7,000 |  |  |  |  | * |
Napoleone Ferrara, M.D.(10) |  |  |  | 511,000 |  |  |  |  | 2.2 | %
David Hallal(11) |  |  |  | 862,543 |  |  |  |  | 3.8 | %
Morana Jovan-Embiricos, Ph.D.(12) |  |  |  | 1,163,652 |  |  |  |  | 5.1 | %
Leone Patterson(13) |  |  |  | 6,500 |  |  |  |  | * |
All current executive officers and directors as a group (10 persons)(14) |  |  |  | 15,957,025 |  |  |  |  | 68.1 | %

* | Less than 1%.

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(1) | Information is based on a Schedule 13D/A filed with the SEC on February 17, 2026. Consists of 10,968,234 shares of common stock held by Samsara LP and 1,979,847 shares of common stock held by Samsara Opportunity Fund, L.P., or Opportunity Fund. We refer to Opportunity Fund, together with Samsara LP, as the Samsara Entities. Samsara BioCapital GP, LLC, or Samsara GP LLC, is the general partner of Samsara LP and may be deemed to beneficially own the shares held by Samsara LP. Samsara Opportunity Fund GP, LLC, or Opportunity LLC, is the general partner of Opportunity Fund and may be deemed to beneficially own the shares held by Opportunity Fund. Dr. Akkaraju has voting and investment power over the shares held by Samsara GP LLC and Opportunity LLC and, accordingly, may be deemed to beneficially own the shares held by the Samsara Entities. Each of Samsara GP LLC and Opportunity LLC disclaims beneficial ownership in these shares except to the extent of its respective pecuniary interest therein. The principal business address of the Samsara Entities is 628 Middlefield Rd., Palo Alto, California 94301.

(2) | Information is based in part on a Schedule 13D/A filed with the SEC on February 17, 2026. Consists of (i) 679,766 shares of common stock held by RTW Master Fund, Ltd., (ii) 568,613 shares of common stock held by RTW Innovation Master Fund, Ltd. and (iii) 51,621 shares of common stock held by RTW Biotech Opportunities, Ltd. We refer to RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd. and RTW Biotech Opportunities, Ltd. collectively as the RTW Funds. The shares reported under “Number of Shares of Common Stock Being Offered” consist of the 1,300,000 shares of common stock issued to the RTW Funds in the 2025 Private Placement. RTW Investments, LP, or RTW, in its capacity as the investment manager of the RTW Funds, has the power to vote and the power to direct the disposition of the shares held by the RTW Funds. Accordingly, RTW may be deemed to be the beneficial owner of such shares. Roderick Wong, M.D., as the Managing Partner of RTW, has the power to direct the vote and disposition of the shares held by RTW. Dr. Wong disclaims beneficial ownership of the shares held by the RTW Funds, except to the extent of his pecuniary interest therein. The address and principal office of RTW Investments, LP is 40 10th Avenue, Floor 7, New York, NY 10014, and the address of Dr. Wong and each of the RTW Funds is c/o RTW Investments, LP, 40 10th Avenue, Floor 7, New York, NY 10014.

(3) | Consists of 341,877 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(4) | Consists of (i) 4,030 shares of common stock held directly and (ii) 65,869 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(5) | Consists of 14,660 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(6) | Consists of (i) 49,129 shares of common stock held directly and (ii) 724,989 shares of common stock held by ElevateBio. Information is based on Mr. Sinha’s holdings as of immediately following the closing of the Merger on March 18, 2025. Mr. Sinha is a director and the chief financial officer of ElevateBio. Mr. Sinha, David Hallal and Morana Jovan-Embiricos, Ph.D., members of the board of directors of ElevateBio, may be deemed to have shared voting and investment power over the shares of common stock held of record by ElevateBio. Such persons disclaim beneficial ownership of all shares of common stock held by ElevateBio except to the extent of any indirect pecuniary interests therein. The mailing address of ElevateBio LLC is 200 Smith Street, Waltham, MA 02451.

(7) | Consists of 39,473 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(8) | Consists of (i) 12,948,081 shares of common stock held by Samara described in note (1) above and (ii) 7,000 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(9) | Consists of 7,000 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(10) | Consists of (i) 504,000 shares of common stock held directly and (ii) 7,000 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(11) | Consists of (i) 93,202 shares of common stock held directly, (ii) 31,346 shares of common stock held by The Hallal Family Irrevocable Trust 2012, (iii) 6,006 shares of common stock held by Terrie A. Hallal Family Irrevocable Trust 2012, (iv) 724,989 shares of common stock held by ElevateBio and (v) 7,000 shares of common stock underlying options exercisable within 60 days of April 1, 2026. Mr. Hallal is a trustee of the previously listed trusts and may be deemed to beneficially own these securities. Mr. Hallal is the chairman of ElevateBio. Mr. Hallal and Morana Jovan-Embiricos, Ph.D., members of the board of directors of ElevateBio, may be deemed to have shared voting and investment power over the shares of common stock held of record by ElevateBio. Such persons disclaim beneficial ownership of all shares of

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| common stock held by ElevateBio except to the extent of any indirect pecuniary interests therein. The mailing address of ElevateBio LLC is 200 Smith Street, Waltham, MA 02451.

(12) | Consists of (i) 4,356 shares of common stock held directly, (ii) 29,046 shares of common stock held by F2 TPO Investment, LLC, (iii) 89,560 shares of common stock held by F2 MG Ltd., (iv) 88,634 shares of common stock held by F2 MC, LLC, (v) 182,342 shares of common stock held by F2 Capital I 2020 LLC, (vi) 37,725 shares of common stock held by F2 Bioscience AV 2022 LLC, (vii) 724,989 shares of common stock held by ElevateBio and (viii) 7,000 shares of common stock underlying options exercisable within 60 days of April 1, 2026. The mailing address of ElevateBio LLC is 200 Smith Street, Waltham, MA 02451. Dr. Jovan-Embiricos is a director of ElevateBio. Dr. Jovan-Embiricos and David Hallal, members of the board of directors of ElevateBio, may be deemed to have shared voting and investment power over the shares of common stock held of record by ElevateBio. Such persons disclaim beneficial ownership of all shares of common stock held by ElevateBio except to the extent of any indirect pecuniary interests therein. The mailing address for F2-TPO Investment, LLC, F2 MC, LLC and F2 Capital I 2020 LLC is c/o Singer McKeon, Inc., 8 West 28th Street, Suite 1001, New York, NY 10018. The mailing address for F2 MG Ltd. is PO Box 3175, Road Town, Tortola, BVA, with correspondence address at c/o LJ Fiduciary, 8 Rue Saint-Leger, CH 1205, Geneva, Switzerland. Morana Jovan-Embiricos, Ph.D. is a member of the board and is the founding director of Globeways Holdings Limited, which is the appointed manager of each of F2 MG Ltd., F2-TPO Investments, LLC, F2 MC, LLC and F2 Capital I 2020 LLC and makes investment decisions on behalf of such entities with respect to shares of common stock held by such entities. Morana Jovan-Embiricos, Ph.D. expressly disclaims beneficial ownership of the securities held by F2 MG Ltd., F2-TPO Investments, LLC, F2 MC, LLC and F2 Capital I 2020 LLC.

(13) | Consists of 6,500 shares of common stock underlying options exercisable within 60 days of April 1, 2026.

(14) | Consists of (i) 15,468,306 shares of common stock held directly or indirectly by all current executive officers and directors as a group and (ii) 488,719 shares issuable pursuant to stock options exercisable within 60 days of April 1, 2025.

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STOCKHOLDER PROPOSALS FOR OUR 2027 ANNUAL MEETING

Stockholder Proposals Included in Proxy Statement

In order to be considered for inclusion in our proxy statement and proxy card relating to our 2027 annual meeting of stockholders, stockholder proposals must be received by us no later than December 25, 2026, which is 120 days prior to the first anniversary of the mailing date of this proxy statement, unless the date of the 2027 annual meeting of stockholders is changed by more than 30 days from the anniversary of the Annual Meeting, in which case, the deadline for such proposals will be a reasonable time before we begin to print and send our proxy materials. Upon receipt of any such proposal, we will determine whether or not to include such proposal in the proxy statement and proxy card in accordance with regulations governing the solicitation of proxies.

Stockholder Proposals Not Included in Proxy Statement

In addition, our amended and restated by-laws establish an advance notice procedure for nominations for election to our board of directors and other matters that stockholders wish to present for action at an annual meeting other than those to be included in our proxy statement. The required notice must be delivered by the stockholder and received by our Secretary at our principal executive office and must otherwise meet the requirements set forth in our amended and restated by-laws. In general, we must receive other proposals of stockholders, including director nominations, intended to be presented at the 2027 annual meeting of stockholders but not included in the proxy statement by March 5, 2027, but not before February 3, 2027, which is not less than 90 days nor more than 120 days prior to the anniversary date of the Annual Meeting. However, if the date of the annual meeting of stockholders is more than 30 days before or more than 60 days after such anniversary date, notice must be received not later than the close of business on the later of 90 days prior to such annual meeting or 10 days following the day on which public announcement of the date of such annual meeting is first made. If the stockholder fails to give notice by these dates, then the persons named as proxies in the proxies solicited by the board of directors for the 2027 annual meeting of stockholders may exercise discretionary voting power regarding any such proposal. Stockholders are advised to review our amended and restated by-laws which also specify requirements as to the form and content of a stockholder’s notice.

In addition to satisfying the advance notice provisions in our amended and restated by-laws, stockholders who intend to solicit proxies in support of director nominees other than our nominees must also comply with the additional requirements of Rule 14a-19(b) under the Exchange Act. In addition, to comply with the universal proxy rules, stockholders who intend to solicit proxies in support of director nominees other than our nominees must provide notice that sets forth the information required by Rule 14a-19 under the Exchange Act no later than April 4, 2027. If the date of the 2027 annual meeting of stockholders changes by more than 30 days from the anniversary of the Annual Meeting, such notice must instead be provided by the later of 60 days prior to the date of the 2027 annual meeting of stockholders or the 10th day following public announcement by us of the date of the 2027 annual meeting of stockholders.

Any proposals, notices or information about proposed director candidates should be sent to Kalaris Therapeutics, Inc., Attention: Secretary, 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922.

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HOUSEHOLDING OF ANNUAL MEETING MATERIALS

Some brokers and other nominee record holders may be “householding” our proxy materials. This means a single notice and, if applicable, the proxy materials, will be delivered to multiple stockholders sharing an address unless contrary instructions have been received. We will promptly deliver a separate copy of the notice and, if applicable, the proxy materials and our 2025 Annual Report, which consists of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, to you if you write or call us at Kalaris Therapeutics, Inc., 400 Connell Drive, Suite 5500, Berkeley Heights, New Jersey 07922, Attention: Secretary, email: ir@kalaristx.com, telephone: (650) 249-2727. If you would like to receive separate copies of our proxy materials and annual reports in the future, or if you are receiving multiple copies and would like to receive only one copy for your household, you should contact your bank, broker or other nominee record holder, or you may contact us at the above address and telephone number.

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OTHER MATTERS

We do not know of any business that will be presented for consideration or action by the stockholders at the Annual Meeting other than that described in this proxy statement. If, however, any other business is properly brought before the meeting, shares represented by proxies will be voted in accordance with the best judgment of the persons named in the proxies or their substitutes.

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styleIPC Your vote P.O. BOX 8016, CARY, NC 27512-9903 matters! Have your ballot ready and please use one of the methods below for easy voting: Your control number Have the 12 digit control number located in the box above available when you access the website and follow the instructions. Kalaris Therapeutics, Inc. Internet: www.proxypush.com/KLRS Cast your vote online Annual Meeting of Stockholders Have your Proxy Card ready Follow the simple instructions to record your vote For Stockholders of Record as of April 6, 2026 Phone: Wednesday, June 3, 2026 11:30 AM, Eastern Time 1-866-314-3599 This meeting will be held exclusively via the Internet- please visit Use any touch-tone telephone Have your Proxy Card ready www.proxydocs.com/KLRS for more details. Follow the simple recorded instructions Mail: Mark, sign and date your Proxy Card Fold and return your Proxy Card in the postage-paid YOUR VOTE IS IMPORTANT! envelope provided PLEASE VOTE BY: 11:59 PM, Eastern Time, June 2, 2026. Virtual: You must register to attend the meeting online and/or participate at www.proxydocs.com/KLRS This proxy is being solicited on behalf of the Board of Directors The undersigned hereby appoints Andrew Oxtoby and Brett Hagen (the “Named Proxies”), and each of them, as the true and lawful attorneys of the undersigned, with full power of substitution and revocation, and authorizes them, and each of them, to vote all the shares of common stock of Kalaris Therapeutics, Inc. which the undersigned is entitled to vote at said meeting and any adjournment or postponement thereof upon the matters specified and upon such other matters as may be properly brought before the meeting or any adjournment or postponement thereof, conferring authority upon such true and lawful attorneys to vote in their discretion on such other matters as may properly come before the meeting and revoking any proxy heretofore given. THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO DIRECTION IS GIVEN, SHARES WILL BE VOTED IDENTICAL TO THE BOARD OF DIRECTORS RECOMMENDATION. This proxy, when properly executed, will be voted in the manner directed herein. In their discretion, the Named Proxies are authorized to vote upon such other matters that may properly come before the meeting or any adjournment or postponement thereof. You are encouraged to specify your choice by marking the appropriate box (SEE REVERSE SIDE) but you need not mark any box if you wish to vote in accordance with the Board of Directors’ recommendation. The Named Proxies cannot vote your shares unless you sign (on the reverse side) and return this card. PLEASE BE SURE TO SIGN AND DATE THIS PROXY CARD AND MARK ON THE REVERSE SIDE Copyright 2026 BetaNXT, Inc. or its affiliates. All Rights Reserved

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Kalaris Therapeutics, Inc. Annual Meeting of Stockholders Please make your marks like this: THE BOARD OF DIRECTORS RECOMMENDS A VOTE: FOR EACH OF THE DIRECTOR NOMINEES IN PROPOSAL 1, FOR PROPOSAL 2, ONE YEAR FOR PROPOSAL 3 AND FOR PROPOSAL 4. BOARD OF DIRECTORS PROPOSAL YOUR VOTE RECOMMENDS 1. The election of three Class III directors, each to serve for a three-year term expiring at the 2029 annual meeting of stockholders and until his or her respective successor has been duly elected and qualified. FOR WITHHOLD 1.01 Napoleone Ferrara, M.D. FOR #P2# #P2# 1.02 David Hallal FOR #P3# #P3# 1.03 Leone Patterson FOR #P4# #P4# FOR AGAINST ABSTAIN 2. The approval of an advisory vote on executive compensation. FOR #P5# #P5# #P5# ONE YR TWO YRS THREE YRS ABSTAIN 3. The holding of an advisory vote on the frequency of future executive compensation ONE YEAR advisory votes. #P6# #P6# #P6# #P6# FOR AGAINST ABSTAIN 4. The ratification of the selection of Deloitte & Touche LLP as our independent FOR registered public accounting firm for the fiscal year ending December 31, 2026. #P7# #P7# #P7# Note: The meeting transaction of stockholders of any other or any business adjournment that may or postponement properly come thereof before .the 2026 annual You must register to attend the meeting online and/or participate at www.proxydocs.com/KLRS Authorized Signatures—Must be completed for your instructions to be executed. Please sign exactly as your name(s) appears on your account. If held in joint tenancy, all persons should sign. Trustees, administrators, etc., should include title and authority. Corporations should provide full name of corporation and title of authorized officer signing the Proxy/Vote Form. Signature (and Title if applicable) Date Signature (if held jointly) Date