144 0001689575 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Katherine Stueland Director Officer Class A Common Stock Morgan Stanley Smith Barney 2000 Westchester Avenue Purchase NY 10577 16415 1037500 29288739 04/29/2026 NASDAQ Class A Common Stock 05/02/2022 Acquired as compensation - Restricted Stock Units Issuer N 2172 05/02/2022 Compensation Class A Common Stock 12/09/2022 Acquired as compensation - Restricted Stock Units Issuer N 3686 12/09/2022 Compensation Class A Common Stock 04/26/2023 Acquired as compensation - Restricted Stock Units Issuer N 10557 04/26/2023 Compensation N Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 01/29/2026 1653 155375 Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/04/2026 25459 2001371 Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/09/2026 3678 319059 Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/16/2026 17179 1319291 Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/26/2026 46933 2964841 Represents approximately 16,415 shares to be sold on behalf of the Reporting Person, including 1) 2,172 shares to be sold in connection with vesting of RSUs on April 29, 2026; 2) approximately 3,686 shares to be sold in connection with anticipated vesting of RSUs on June 9, 2026; and 3) approximately 10,557 shares to be sold in connection with anticipated vesting of RSUs on June 16, 2026. Shares sold in the past 3 months by the Reporting Person include 94,902 shares sold to cover tax withholding obligations in connection with vesting and settlement of restricted stock units. 04/29/2026 /s/ Katherine Stueland