<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001797409</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001829802</issuerCik>
      <issuerName>Sensei Biotherapeutics, Inc.</issuerName>
      <secFileNumber>001-39980</secFileNumber>
      <issuerAddress>
        <com:street1>1405 RESEARCH BLVD, SUITE 125</com:street1>
        <com:city>ROCKVILLE</com:city>
        <com:stateOrCountry>MD</com:stateOrCountry>
        <com:zipCode>20850</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(240) 243-8000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cambrian BioPharma Inc</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>155142</noOfUnitsSold>
      <aggregateMarketValue>4956786.00</aggregateMarketValue>
      <noOfUnitsOutstanding>1340281</noOfUnitsOutstanding>
      <approxSaleDate>04/29/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/10/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>155142</amountOfSecuritiesAcquired>
      <paymentDate>01/10/2020</paymentDate>
      <natureOfPayment>Cash/Check</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/29/2026</noticeDate>
      <signature>/s/ Daniel Gardea as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Cambrian BioPharma Inc.</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>