10X GENOMICS INC CL A COM 88025U109 7530345 354703 SH SOLE 354703 0 0 3M CO COM 88579Y101 6425120 44241 SH SOLE 44241 0 0 4D MOLECULAR THERAPEUTICS IN COM 35104E100 655703 70430 SH SOLE 70430 0 0 ABBOTT LABORATORIES COM 002824100 1592001 15506 SH SOLE 15506 0 0 ABBVIE INC COM 00287Y109 10574581 48621 SH SOLE 48621 0 0 ABEONA THERAPEUTICS INC COM NEW 00289Y206 2275786 507988 SH SOLE 507988 0 0 ACHIEVE LIFE SCIENCE INC COM 004468500 3482465 1184512 SH SOLE 1184512 0 0 ADOBE INC COM 00724F101 550819 2266 SH SOLE 2266 0 0 AGNC INVT CORP COM 00123Q104 1037955 103485 SH SOLE 103485 0 0 ALIGN TECHNOLOGY INC COM 016255101 18325353 106897 SH SOLE 106897 0 0 ALIGNMENT HEALTHCARE INC COM 01625V104 3401224 193032 SH SOLE 193032 0 0 AMERICAN EXPRESS CO COM 025816109 255898 846 SH SOLE 846 0 0 AMGEN INC COM 031162100 5574711 15844 SH SOLE 15844 0 0 ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839 1044873 49403 SH SOLE 49403 0 0 APPLIED MATLS INC COM 038222105 333245 975 SH SOLE 975 0 0 AQUESTIVE THERAPEUTICS INC COM 03843E104 972258 234279 SH SOLE 234279 0 0 ARMOUR RESIDENTIAL REIT INC COM SHS 042315705 899052 53900 SH SOLE 53900 0 0 ARTIVA BIOTHERAPEUTICS INC COM 04317A107 149601 23230 SH SOLE 23230 0 0 ASTRAZENECA PLC ORD G0593M107 5091826 25818 SH SOLE 25818 0 0 AUTODESK INC COM 052769106 263819 1102 SH SOLE 1102 0 0 BENITEC BIOPHARMA INC COM NEW 08205P209 5987877 562242 SH SOLE 562242 0 0 BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 1256462 2622 SH SOLE 2622 0 0 BIOHAVEN LTD COM G1110E107 7600464 898400 SH SOLE 898400 0 0 BIT DIGITAL INC SHS G1144A105 30710 23443 SH SOLE 23443 0 0 BLACKROCK INC COM 09290D101 205806 214 SH SOLE 214 0 0 BOOKING HOLDINGS INC COM 09857L108 227357 54 SH SOLE 54 0 0 BOSTON SCIENTIFIC CORP COM 101137107 710581 11324 SH SOLE 11324 0 0 CADENCE DESIGN SYSTEM INC COM 127387108 384016 1382 SH SOLE 1382 0 0 CATERPILLAR INC COM 149123101 406656 574 SH SOLE 574 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 2188490 68994 SH SOLE 68994 0 0 CHIMERA INVT CORP COM SHS 16934Q802 640364 51025 SH SOLE 51025 0 0 CIENA CORP COM NEW 171779309 225562 581 SH SOLE 581 0 0 CISCO SYS INC COM 17275R102 1540860 19859 SH SOLE 19859 0 0 CLOUDFLARE INC CL A COM 18915M107 323128 1566 SH SOLE 1566 0 0 COCA COLA CO COM 191216100 306786 4034 SH SOLE 4034 0 0 COHERUS ONCOLOGY INC COM 19249H103 427807 253140 SH SOLE 253140 0 0 COMCAST CORP NEW CL A 20030N101 524283 18691 SH SOLE 18691 0 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 879558 159052 SH SOLE 159052 0 0 CONNECT BIOPHARMA HLDGS LTD SHS G23549101 134864 51475 SH SOLE 51475 0 0 COOPER COS INC COM 216648501 710853 9942 SH SOLE 9942 0 0 CORCEPT THERAPEUTICS INC COM 218352102 1522227 37763 SH SOLE 37763 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 296140 20242 SH SOLE 20242 0 0 CVS HEALTH CORP COM 126650100 3879214 54013 SH SOLE 54013 0 0 CYPHERPUNK TECHNOLOGIES INC COM NEW 52187K200 16797 21139 SH SOLE 21139 0 0 DANAHER CORP DEL COM 235851102 6124838 32304 SH SOLE 32304 0 0 DATADOG INC CL A COM 23804L103 201511 1707 SH SOLE 1707 0 0 DELCATH SYS INC COM NEW 24661P807 2423249 261126 SH SOLE 261126 0 0 DELL TECHNOLOGIES INC CL C 24703L202 504371 3073 SH SOLE 3073 0 0 DYNEX CAP INC COM 26817Q886 1040948 81579 SH SOLE 81579 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 1127366 14078 SH SOLE 14078 0 0 ELECTRONIC ARTS INC COM 285512109 254430 1248 SH SOLE 1248 0 0 ELI LILLY & CO COM 532457108 15362918 16703 SH SOLE 16703 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 3009851 53009 SH SOLE 53009 0 0 EXXON MOBIL CORP COM 30231G102 826414 4871 SH SOLE 4871 0 0 EYEPOINT INC COM NEW 30233G209 4203970 326142 SH SOLE 326142 0 0 FLUOR CORP COM 343412102 254289 5451 SH SOLE 5451 0 0 FORTINET INC COM 34959E109 300403 3676 SH SOLE 3676 0 0 FULCRUM THERAPEUTICS INC COM 359616109 889674 115994 SH SOLE 115994 0 0 GE AEROSPACE COM NEW 369604301 473045 1667 SH SOLE 1667 0 0 GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 2794527 39260 SH SOLE 39260 0 0 GE VERNOVA INC COM 36828A101 313371 359 SH SOLE 359 0 0 GILEAD SCIENCES INC COM 375558103 8549653 61345 SH SOLE 61345 0 0 GUARDANT HEALTH INC COM 40131M109 1923236 20821 SH SOLE 20821 0 0 HOME DEPOT INC COM 437076102 337770 1027 SH SOLE 1027 0 0 HONEYWELL INTL INC COM 438516106 232133 1027 SH SOLE 1027 0 0 IMMUNIC INC COM 4525EP101 487215 438932 SH SOLE 438932 0 0 INSMED INC COM PAR $.01 457669307 1763236 10783 SH SOLE 10783 0 0 INTERNATIONAL BUSINESS MACHS COM 459200101 1161048 4790 SH SOLE 4790 0 0 INTUIT COM 461202103 612250 1416 SH SOLE 1416 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 4963479 10767 SH SOLE 10767 0 0 INVENTIVA SA ADS 46124U107 1264973 227923 SH SOLE 227923 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 40179 11447 SH SOLE 11447 0 0 ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 29946000 775000 SH Call SOLE 775000 0 0 ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 26894000 700000 SH SOLE 700000 0 0 ISHARES TR CORE S&P500 ETF 464287200 713479074 1092266 SH SOLE 1092266 0 0 ISHARES TR CORE US AGGBD ET 464287226 407013552 4100066 SH SOLE 4100066 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 9779556 51730 SH SOLE 51730 0 0 JOHNSON & JOHNSON COM 478160104 8096097 33121 SH SOLE 33121 0 0 KALARIS THERAPEUTICS INC COM 482929106 504448 87426 SH SOLE 87426 0 0 KYVERNA THERAPEUTICS INC COM 501976104 1493905 173106 SH SOLE 173106 0 0 LAM RESEARCH CORP COM NEW 512807306 326045 1526 SH SOLE 1526 0 0 LEONABIO INC COM 04746L203 1534588 149279 SH SOLE 149279 0 0 MASTERCARD INCORPORATED CL A 57636Q104 762481 1526 SH SOLE 1526 0 0 MERCK & CO INC COM 58933Y105 787178 6544 SH SOLE 6544 0 0 MFA FINL INC COM 55272X607 2002220 209000 SH SOLE 209000 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 1792622 1506405 SH SOLE 1506405 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 330009 2505 SH SOLE 2505 0 0 NOVO-NORDISK A S ADR 670100205 12030370 327357 SH SOLE 327357 0 0 OCULAR THERAPEUTIX INC COM 67576A100 762300 90000 SH SOLE 90000 0 0 OCULIS HOLDING AG ORDINARY SHARES H5870P102 1772676 66667 SH SOLE 66667 0 0 ORCHESTRA BIOMED HLDGS INC COM 68572M106 932395 219387 SH SOLE 219387 0 0 OVID THERAPEUTICS INC COM 690469101 290405 130813 SH SOLE 130813 0 0 OXFORD LANE CAP CORP COM 691543847 978000 100000 SH SOLE 100000 0 0 PACIRA BIOSCIENCES INC COM 695127100 1415958 62653 SH SOLE 62653 0 0 PALANTIR TECHNOLOGIES INC CL A 69608A108 1712061 11704 SH SOLE 11704 0 0 PALISADE BIO INC COM 696389402 612500 350000 SH SOLE 350000 0 0 PALO ALTO NETWORKS INC COM 697435105 635989 3967 SH SOLE 3967 0 0 PEPSICO INC COM 713448108 202653 1305 SH SOLE 1305 0 0 PHATHOM PHARMACEUTICALS INC COM 71722W107 2915108 262386 SH SOLE 262386 0 0 PHILIP MORRIS INTL INC COM 718172109 235940 1427 SH SOLE 1427 0 0 PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 30892901 1272360 SH SOLE 1272360 0 0 PURECYCLE TECHNOLOGIES INC COM 74623V103 9190338 1770778 SH SOLE 1770778 0 0 QUALCOMM INC COM 747525103 717820 5574 SH SOLE 5574 0 0 REGENERON PHARMACEUTICALS COM 75886F107 8421776 10900 SH SOLE 10900 0 0 RITHM CAPITAL CORP COM NEW 64828T201 3190902 336593 SH SOLE 336593 0 0 ROCKWELL AUTOMATION INC COM 773903109 203844 568 SH SOLE 568 0 0 SAB BIOTHERAPEUTICS INC COM NEW 78397T202 717091 187230 SH SOLE 187230 0 0 SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103 385884 985 SH SOLE 985 0 0 SERVICENOW INC COM 81762P102 566766 5421 SH SOLE 5421 0 0 SIMPLIFY EXCHANGE TRADED FUN ANCORATO TARGET 82889N343 2832500 125000 SH SOLE 125000 0 0 SIMPLIFY EXCHANGE TRADED FUN TARGET 15 DISTRI 82889N350 14711005 624406 SH SOLE 624406 0 0 SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533 45792310 3777620 SH SOLE 3777620 0 0 SIMPLIFY EXCHANGE TRADED FUN TREASURY OPT INC 82889N640 39958500 1700000 SH SOLE 1700000 0 0 SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657 116655570 5528700 SH SOLE 5528700 0 0 SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442 37530496 1553376 SH SOLE 1553376 0 0 SIMPLIFY EXCHANGE TRADED FUN PIPER SANDLER US 82889N327 2612596 91464 SH SOLE 91464 0 0 SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723 42920734 2109127 SH SOLE 2109127 0 0 SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475 24416890 822303 SH SOLE 822303 0 0 SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699 4574734 151381 SH SOLE 151381 0 0 SIMPLIFY EXCHANGE TRADED FUN GOVERNMENT MONEY 82889N269 4606639826 46038775 SH SOLE 46038775 0 0 SIMPLIFY EXCHANGE TRADED FUN US EQT PLS UPSID 82889N301 72225994 1634812 SH SOLE 1634812 0 0 SIMPLIFY EXCHANGE TRADED FUN US EQUITY PLUS M 82889N228 2678240 100000 SH SOLE 100000 0 0 SNOWFLAKE INC COM SHS 833445109 260617 1728 SH SOLE 1728 0 0 SPOTIFY TECHNOLOGY S A SHS L8681T102 520793 1074 SH SOLE 1074 0 0 STRYKER CORPORATION COM 863667101 561889 1710 SH SOLE 1710 0 0 TESLA INC COM 88160R101 4124194 11094 SH SOLE 11094 0 0 TG THERAPEUTICS INC COM 88322Q108 533148 16049 SH SOLE 16049 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 8557046 17409 SH SOLE 17409 0 0 TREVI THERAPEUTICS INC COM 89532M101 780365 65412 SH SOLE 65412 0 0 UBER TECHNOLOGIES INC COM 90353T100 236722 3291 SH SOLE 3291 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 20310158 34251 SH SOLE 34251 0 0 UNITEDHEALTH GROUP INC COM 91324P102 784982 2901 SH SOLE 2901 0 0 UPSTREAM BIO INC COM 91678A107 700137 77793 SH SOLE 77793 0 0 VANECK BITCOIN ETF SH BEN INT 92189K105 4007333 209151 SH SOLE 209151 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 3543741 7936 SH SOLE 7936 0 0 VIRIDIAN THERAPEUTICS INC COM 92790C104 1099878 56231 SH SOLE 56231 0 0 VOR BIOPHARMA INC COM NEW 929033207 954618 53510 SH SOLE 53510 0 0 WALMART INC COM 931142103 1766889 14217 SH SOLE 14217 0 0 WARBY PARKER INC CL A COM 93403J106 6127809 290831 SH SOLE 290831 0 0 WESTERN DIGITAL CORP COM 958102105 414661 1533 SH SOLE 1533 0 0 XCF GLOBAL INC COM CL A 98400U103 69027 188857 SH SOLE 188857 0 0 ZEVRA THERAPEUTICS INC COM NEW 488445206 937872 100630 SH SOLE 100630 0 0 ZIMMER BIOMET HOLDINGS INC COM 98956P102 299742 3315 SH SOLE 3315 0 0