144 0001944119 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Kevin Feeley Officer Class A Common Stock Morgan Stanley Smith Barney 2000 Westchester Avenue Purchase NY 10577 5804 366000 29288739 04/29/2026 NASDAQ Class A Common Stock 05/02/2022 Acquired as compensation - Restricted Stock Units Issuer N 392 05/02/2022 Compensation Class A Common Stock 09/01/2022 Acquired as compensation - Restricted Stock Units Issuer N 374 09/01/2022 Compensation Class A Common Stock 12/09/2022 Acquired as compensation - Restricted Stock Units Issuer N 1284 12/09/2022 Compensation Class A Common Stock 04/26/2023 Acquired as compensation - Restricted Stock Units Issuer N 3754 04/26/2023 Compensation N Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 01/29/2026 317 29794 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/02/2026 287 22248 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/04/2026 6187 486370 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/09/2026 1280 111045 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/16/2026 5706 438203 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 03/26/2026 8818 557051 Represents approximately 5,804 shares to be sold on behalf of the Reporting Person, including 1) 392 shares to be sold in connection with vesting of RSUs on April 29, 2026; 2) approximately 374 shares to be sold in connection with anticipated vesting of RSUs on June 1, 2026; 3) approximately 1,284 shares to be sold in connection with anticipated vesting of RSUs on June 9, 2026; and 4) approximately 3,754 shares to be sold in connection with anticipated vesting of RSUs on June 16, 2026. Shares sold in the past 3 months by the Reporting Person include 22,595 shares sold to cover tax withholding obligations in connection with vesting and settlement of restricted stock units. 04/29/2026 /s/ Kevin Feeley