X0607 3/A 2025-08-24 2025-08-25 0 0001006281 Protalix BioTherapeutics, Inc. PLX 0001975896 Mamlok Gilad true CO PROTALIX BIOTHERAPEUTICS, INC. 2 SNUNIT STREET, SCIENCE PARK, P.O. BOX CARMIEL L3 2161401 ISRAEL false true false false Sr. VP and CFO Common Stock 3631 D Stock Option (Right to Buy) 1.45 2035-07-20 Common Stock 597990 D The shares of common stock underlying the stock options shall vest in 12 equal quarterly installments commencing upon the date of grant. The stock options are subject to accelerated vesting upon a corporate transaction or a change in control as described in the Protalix BioTherapeutics, Inc., Amended and Restated 2006 Stock Incentive Plan, as amended. On August 25, 2025, the reporting person filed a Form 3 which inadvertently omitted the reporting person's beneficial ownership of 3,631 shares of the issuer's common stock. /s/ Gilad Mamlok 2026-04-27