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  <!-- Generated by Workiva -->
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    <own:filerInfo>
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          <own:cik>0002006045</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
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      <own:liveTestFlag>LIVE</own:liveTestFlag>



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      <own:issuerCik>0001822791</own:issuerCik>
      <own:issuerName>Clene Inc</own:issuerName>
      <own:issuerAddress>
        <com:street1>6550 SOUTH MILLROCK DRIVE</com:street1>
        <com:street2>SUITE G50</com:street2>
        <com:city>SALT LAKE CITY</com:city>
        <com:stateOrCountry>UT</com:stateOrCountry>
        <com:zipCode>84121</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>8016769695</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Symbiosis II LLC</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Former Board Member</own:relationshipToIssuer>
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    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>555 California St</com:street1>
          <com:street2>Ste 1800</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
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      <own:noOfUnitsSold>56916</own:noOfUnitsSold>
      <own:aggregateMarketValue>335804</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>11778307</own:noOfUnitsOutstanding>
      <own:approxSaleDate>04/28/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
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      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>09/30/2024</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Open Market Purchase</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>297066</own:amountOfSecuritiesAcquired>
      <own:paymentDate>09/30/2024</own:paymentDate>
      <own:natureOfPayment>Cash</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
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      <own:sellerDetails>
        <own:name>Symbiosis II LLC</own:name>
        <own:address>
          <com:street1>609 SW 8th St</com:street1>
          <com:street2>Ste 510</com:street2>
          <com:city>Bentonville</com:city>
          <com:stateOrCountry>AR</com:stateOrCountry>
          <com:zipCode>72712</com:zipCode>
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      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>01/28/2026</own:saleDate>
      <own:amountOfSecuritiesSold>8717</own:amountOfSecuritiesSold>
      <own:grossProceeds>42789.36</own:grossProceeds>
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        <own:name>Symbiosis II LLC</own:name>
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          <com:street2>Ste 510</com:street2>
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          <com:stateOrCountry>AR</com:stateOrCountry>
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      <own:saleDate>01/29/2026</own:saleDate>
      <own:amountOfSecuritiesSold>3810</own:amountOfSecuritiesSold>
      <own:grossProceeds>15843.2</own:grossProceeds>
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          <com:street1>609 SW 8th St</com:street1>
          <com:street2>Ste 510</com:street2>
          <com:city>Bentonville</com:city>
          <com:stateOrCountry>AR</com:stateOrCountry>
          <com:zipCode>72712</com:zipCode>
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      <own:saleDate>01/29/2026</own:saleDate>
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      <own:saleDate>02/02/2026</own:saleDate>
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      <own:saleDate>02/03/2026</own:saleDate>
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      <own:saleDate>03/24/2026</own:saleDate>
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      <own:saleDate>03/25/2026</own:saleDate>
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      <own:grossProceeds>39045.14</own:grossProceeds>
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      <own:saleDate>03/26/2026</own:saleDate>
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      <own:saleDate>04/21/2026</own:saleDate>
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    <own:noticeSignature>
      <own:noticeDate>04/28/2026</own:noticeDate>
      <own:signature>Chidozie Ugwumba</own:signature>
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