X0609 4 2026-04-27 0 0001840706 SOPHiA GENETICS SA SOPH 0002014308 Menu Philippe true C/O SOPHIA GENETICS SA LA PIECE 12 ROLLE V8 1180 SWITZERLAND 0 1 0 0 Chief Medical Officer 1 Ordinary Shares 2026-04-27 4 S 0 5000 4.8178 D 261388 D Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c). The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.75 to $4.89, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Elimara Brunetto as Attorney-in-fact for Philippe Menu 2026-04-28