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        <filerCredentials>
          <filerCik>0002020332</filerCik>
          <filerCcc>XXXXXXXX</filerCcc>
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      <period>12-31-2025</period>
      <liveTestFlag>LIVE</liveTestFlag>
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        <nameOfIssuer>32 Biosciences, Inc.</nameOfIssuer>
        <legalStatus>
          <legalStatusForm>Corporation</legalStatusForm>
          <jurisdictionOrganization>DE</jurisdictionOrganization>
          <dateIncorporation>06-05-2023</dateIncorporation>
        </legalStatus>
        <issuerAddress>
          <com:street1>3333 GREEN BAY RD</com:street1>
          <com:street2>SUITE 210</com:street2>
          <com:city>ILLINOIS</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60064</com:zipCode>
        </issuerAddress>
        <issuerWebsite>https://32biosciences.com/</issuerWebsite>
      </issuerInfo>
      <isCoIssuer>N</isCoIssuer>
    </issuerInformation>
    <annualReportDisclosureRequirements>
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      <totalAssetMostRecentFiscalYear>2091486.00</totalAssetMostRecentFiscalYear>
      <totalAssetPriorFiscalYear>1478698.00</totalAssetPriorFiscalYear>
      <cashEquiMostRecentFiscalYear>1857311.00</cashEquiMostRecentFiscalYear>
      <cashEquiPriorFiscalYear>1183699.00</cashEquiPriorFiscalYear>
      <actReceivedMostRecentFiscalYear>0.00</actReceivedMostRecentFiscalYear>
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      <shortTermDebtMostRecentFiscalYear>358681.00</shortTermDebtMostRecentFiscalYear>
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    <signatureInfo>
      <issuerSignature>
        <issuer>32 Biosciences, Inc.</issuer>
        <issuerSignature>Peter Farmakis</issuerSignature>
        <issuerTitle>Chief Executive Officer</issuerTitle>
      </issuerSignature>
      <signaturePersons>
        <signaturePerson>
          <personSignature>Peter Farmakis</personSignature>
          <personTitle>Chairman</personTitle>
          <signatureDate>04-24-2026</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>Jayson Slotnik </personSignature>
          <personTitle>Director</personTitle>
          <signatureDate>04-24-2026</signatureDate>
        </signaturePerson>
        <signaturePerson>
          <personSignature>Franklin R. Cockerill III</personSignature>
          <personTitle>Director</personTitle>
          <signatureDate>04-24-2026</signatureDate>
        </signaturePerson>
      </signaturePersons>
    </signatureInfo>
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