Exhibit 8.1
Subsidiaries of registrant*
| Name of Subsidiary | Jurisdiction of Incorporation | |
| Ascentage Pharma Group Corp Limited | Hong Kong | |
| Jiangsu Ascentage Pharma Co., Limited | People’s Republic of China | |
| Guangzhou Healthquest Pharma Co., Ltd. | People’s Republic of China | |
| Ascentage International Limited | Hong Kong | |
| Ascentage Pharma Group Inc. | United States | |
| Shanghai Yasheng Pharmaceutical Technology Co., Ltd. | People’s Republic of China | |
| Ascentage Pharma Pty. Ltd. | Australia | |
| Suzhou Ascentage Pharma Co., Ltd. | People’s Republic of China | |
| Ascentage Investment International | Cayman Islands | |
| Ascentage Investment Limited | Hong Kong | |
| Suzhou Ascentage Grains Valley Venture Capital Co., Ltd. | People’s Republic of China | |
| Shanghai UUBiopharma Co., Ltd. | People’s Republic of China | |
| Ascentage Pharma Europe Limited | Ireland | |
| Shanghai Centagen Pharma Co., Ltd. | People’s Republic of China | |
| Suzhou Shenghe Innovation Works Biotech Co., Ltd. | People’s Republic of China | |
| Suzhou Gsun No. 8 Equity Investment Partnership (Limited Partnership) | People’s Republic of China | |
| Suzhou Shenghe Innovation Space Development Co., Ltd. | People’s Republic of China |
| * | The English names of the companies registered in the People’s Republic of China represent the best efforts made by the management of the registrant in directly translating the Chinese names of these companies as no English names have been registered. |