X0609 4 2026-04-20 0 0001840706 SOPHiA GENETICS SA SOPH 0002119354 Puylaert Kevin true C/O SOPHIA GENETICS SA LA PIECE 12 ROLLE V8 1180 SWITZERLAND 0 1 0 0 Chief Sales Officer 0 Ordinary Shares 2026-04-20 4 S 0 33 5.0816 D 148197 D Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on April 18, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades. /s/ Elimara Brunetto as Attorney-in-fact for Kevin Puylaert 2026-04-21